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Cited by 2,255

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Endoplasmic reticulum stress: cell life and death decisions

Open access
Xu, C.·2005·Journal of Clinical Investigation

Abstract

Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell stress response, the unfolded protein response, which is aimed initially at compensating for damage but can eventually trigger cell death if ER dysfunction is severe or prolonged. The mechanisms by which ER stress leads to cell death remain enigmatic, with multiple potential participants described but little clarity about which specific death effectors dominate in particular cellular contexts. Important roles for ER-initiated cell death pathways have been recognized for several diseases, including hypoxia, ischemia/reperfusion injury, neurodegeneration, heart disease, and diabetes.

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Metadata

Authors
Xu, C.
Venue
Journal of Clinical Investigation
Published
2005-10-01
Volume
115
Issue
10
Pages
2656-2664
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2165064047
Cited by
2,255
References
7
FWCI
30.55
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Endoplasmic reticulum stress: cell life and death decisions. https://app.cochat.ai/papers/10.1172/jci26373
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Xu, C. (2005). Endoplasmic reticulum stress: cell life and death decisions. Journal of Clinical Investigation. https://doi.org/10.1172/jci26373

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.