The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis
Open accessAbstract
Eosinophilic esophagitis (EE) is an emerging disorder with a poorly understood pathogenesis. In order to define disease mechanisms, we took an empirical approach analyzing esophageal tissue by a genome-wide microarray expression analysis. EE patients had a striking transcript signature involving 1% of the human genome that was remarkably conserved across sex, age, and allergic status and was distinct from that associated with non-EE chronic esophagitis. Notably, the gene encoding the eosinophil-specific chemoattractant eotaxin-3 (also known as CCL26) was the most highly induced gene in EE patients compared with its expression level in healthy individuals. Esophageal eotaxin-3 mRNA and protein levels strongly correlated with tissue eosinophilia and mastocytosis. Furthermore, a single-nucleotide polymorphism in the human eotaxin-3 gene was associated with disease susceptibility. Finally, mice deficient in the eotaxin receptor (also known as CCR3) were protected from experimental EE. These results implicate eotaxin-3 as a critical effector molecule for EE and provide insight into disease pathogenesis.
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DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327
Cited by
Furuta, G. T., Liacouras, C. A., Collins, M. H., Gupta, S. K., Justinich, C., Putnam, P. E., Bonis, P., Hassall, E., Straumann, A., & Rothenberg, M. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.017 · Cited by 1,673
Involvement of mast cells in eosinophilic esophagitis
Abonia, J. P., Blanchard, C., Butz, B. B., Rainey, H. F., Collins, M. H., Stringer, K., Putnam, P. E., & Rothenberg, M. E. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.04.009 · Cited by 287
Self-citationCCR3 is a target for age-related macular degeneration diagnosis and therapy
Takeda, A., Baffi, J. Z., Kleinman, M. E., Cho, W. G., Nozaki, M., Yamada, K., Kaneko, H., Albuquerque, R. J. C., Dridi, S., Saito, K., et al. (2009) · Nature · doi:10.1038/nature08151 · Cited by 263
Epithelial barrier repair and prevention of allergy
Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251
High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
Abonia, J. P., Wen, T., Stucke, E. M., Grotjan, T., Griffith, M. S., Kemme, K. A., Collins, M. H., Putnam, P. E., Franciosi, J. P., von Tiehl, K. F., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.030 · Cited by 195
Voehringer, D., van Rooijen, N., & Locksley, R. M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1106686 · Cited by 173
Diny, N. L., Hou, X., Barin, J. G., Chen, G., Talor, M. V., Schaub, J., Russell, S. D., Klingel, K., Rose, N. R., & Čiháková, D. (2016) · European Journal of Immunology · doi:10.1002/eji.201646557 · Cited by 70
Giordano, D., d’Acierno, A., Marabotti, A., Iovino, P., Iacomino, G., & Facchiano, A. (2024) · Genes · doi:10.3390/genes15081073 · Cited by 1
Metadata
- Authors
- Blanchard, C.
- Venue
- Journal of Clinical Investigation
- Published
- 2006-01-19
- Volume
- 116
- Issue
- 2
- Pages
- 536-547
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2144846148
- Cited by
- 870
- References
- 1
- FWCI
- 51.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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