Cited by 320Alzheimer's disease research and treatmentsRedox biology and oxidative stressNeurobiology and Insect Physiology Research

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Oxidative stress mediates tau-induced neurodegeneration in Drosophila

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Dias-Santagata, Dora, Fulga, Tudor A., Duttaroy, Atanu, Feany, Mel B.·2007·Journal of Clinical Investigation

DOI 10.1172/jci28769PMC PMC1697799

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Abstract

Markers of oxidative damage have been detected in brain tissue from patients with Alzheimer disease (AD) and other neurodegenerative disorders. These findings implicate oxidative injury in the neurodegenerative process, but whether oxidative stress is a cause or a consequence of neurotoxicity remains unclear. We used a Drosophila model of human tauopathies to investigate the role of oxidative stress in neurodegeneration. Genetic and pharmacological manipulation of antioxidant defense mechanisms significantly modified neurodegeneration in our model, suggesting that oxidative stress plays a causal role in neurotoxicity. We demonstrate that the JNK signaling pathway is activated in our model, which is in agreement with previous findings in AD tissue. Furthermore, we show that the extent of JNK activation correlates with the degree of tau-induced neurodegeneration. Finally, our findings suggest that oxidative stress acts not to promote tau phosphorylation, but to enhance tau-induced cell cycle activation. In summary, our study identifies oxidative stress as a causal factor in tau-induced neurodegeneration in Drosophila.

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Authors: Dias-Santagata, D., Fulga, T. A., Duttaroy, A., & Feany, M. B.
Affiliations: Brigham and Women's Hospital (US)
Howard University (US)
ORCID: Dias-Santagata, Dora
Fulga, Tudor A.
Duttaroy, Atanu
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-01-02
Volume: 117
Issue: 1
Pages: 236-245
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci28769
PMC: PMC1697799
OpenAlex: W1997198091
Cited by: 318
References: 61
Citations by year: 2026: 6 · 2025: 22 · 2024: 20 · 2023: 21 · 2022: 21 · 2021: 24 · 2020: 15 · 2019: 16 · 2018: 14 · 2017: 15 · 2016: 15 · 2015: 21 · 2014: 14 · 2013: 7 · 2012: 13
FWCI: 7.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Brigham and Women's Hospital
National Institutes of Health (AG005134)
Fundação para a Ciência e a Tecnologia (SFRH/BPD/20685/2004)
National Institute on Aging (AG005134, AG-19790, P50AG005134, R01AG019790)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: oxidative stress, tau protein, tauopathy, neurodegeneration, Alzheimer's disease, JNK signaling, antioxidant defense, cell cycle activation, Drosophila model, tau phosphorylation
MeSH terms: Alzheimer Disease, Animals, Disease Models, Animal, Drosophila, Humans, Nerve Degeneration, Paraquat, Vitamin E, tau Proteins, Oxidative Stress, Tauopathies

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Oxidative stress mediates tau-induced neurodegeneration in Drosophila

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