Cited by 1,152Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Alzheimer’s disease

Cummings, Jeffrey L.·2004·New England Journal of Medicine

Abstract

The prevalence of Alzheimer's disease is predicted to reach 13.2 million cases in the United States. This article considers current therapeutic approaches for Alzheimer's disease. Optimal management requires accurate diagnosis, which is increasingly based on an understanding of pathophysiology. Neuroprotective strategies, cholinesterase inhibitors, psychopharmacologic agents that may reduce behavioral disturbances, and newer agents such as memantine are discussed.

Integrity signals

Registry

Crossref · 10.1056/nejmra040223

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79 of 79 references verified0 citation errors · 0 not checkable

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Authors
Cummings, J. L.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Cummings, Jeffrey L.
Venue
New England Journal of Medicine
Published
2004-07
Volume
351
Issue
1
Pages
56-67
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W4234060991
Cited by
1,152
References
79
Citations by year
2026: 13 · 2025: 27 · 2024: 31 · 2023: 35 · 2022: 23 · 2021: 33 · 2020: 56 · 2019: 44 · 2018: 46 · 2017: 55 · 2016: 53 · 2015: 56 · 2014: 50 · 2013: 57 · 2012: 74
FWCI
10.28
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG 10483, P50AG016570, P50-AG 16570)
  • National Center for Research Resources (RR00856)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
Alzheimer's disease, prevalence, treatment options, diagnosis, pathophysiology, neuroprotection, cholinesterase inhibitors, behavioral problems, memantine
MeSH terms
Alzheimer Disease, Antioxidants, Brain, Cholinesterase Inhibitors, Humans, Memantine, Psychotropic Drugs, Radionuclide Imaging, Amyloid beta-Peptides, Cell Death, Caregivers, Excitatory Amino Acid Antagonists

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