Alzheimer’s disease
Abstract
The prevalence of Alzheimer's disease is predicted to reach 13.2 million cases in the United States. This article considers current therapeutic approaches for Alzheimer's disease. Optimal management requires accurate diagnosis, which is increasingly based on an understanding of pathophysiology. Neuroprotective strategies, cholinesterase inhibitors, psychopharmacologic agents that may reduce behavioral disturbances, and newer agents such as memantine are discussed.
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The natural history of Alzheimer's disease starts slowly in late middle age with mild memory deficits that progress to amnestic mild cognitive impairment, which in turn progresses to dementia.
“The natural history of AD starts slowly in late middle age with mild memory deficits that progress to amnestic mild cognitive impairment (AMCI) [6], which in turn progresses to dementia [7].”
From Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial (2016) · cites this paper as [7]
FDG PET with MRI coregistration and a Region of Interest approach as conducted in this study have been shown to have good six-month test-retest reliability for ROIs affected in Alzheimer's disease.
“FDG PET with MRI coregistration and a Region of Interest (ROI) approach as conducted in this study have been shown to have good six-month test-retest reliability for ROIs affected in AD[7].”
From Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial (2016) · cites this paper as [7]
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- Authors
- Cummings, J. L.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Cummings, Jeffrey L.
- ORCID
- Cummings, Jeffrey L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2004-07
- Volume
- 351
- Issue
- 1
- Pages
- 56-67
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4234060991
- Cited by
- 1,152
- References
- 79
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 31 · 2023: 35 · 2022: 23 · 2021: 33 · 2020: 56 · 2019: 44 · 2018: 46 · 2017: 55 · 2016: 53 · 2015: 56 · 2014: 50 · 2013: 57 · 2012: 74
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 10483, P50AG016570, P50-AG 16570)
- National Center for Research Resources (RR00856)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, prevalence, treatment options, diagnosis, pathophysiology, neuroprotection, cholinesterase inhibitors, behavioral problems, memantine
- MeSH terms
- Alzheimer Disease, Antioxidants, Brain, Cholinesterase Inhibitors, Humans, Memantine, Psychotropic Drugs, Radionuclide Imaging, Amyloid beta-Peptides, Cell Death, Caregivers, Excitatory Amino Acid Antagonists
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