Cited by 87Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionRedox biology and oxidative stress

Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome

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Gladwin, Mark T.·2006·Journal of Clinical Investigation

Abstract

In this issue of the JCI, Stasch and colleagues suggest that a novel drug, BAY 58-2667, potently activates a pool of oxidized and heme-free soluble guanylyl cyclase (sGC; see the related article beginning on page 2552). The increased vasodilatory potency of BAY 58-2667 the authors found in a number of animal models of endothelial dysfunction and in human blood vessels from patients with diabetes suggests that there exists a subphenotype of endothelial dysfunction characterized by receptor-level NO resistance. Diseases associated with NO resistance would appear to be ideally suited for therapies directed at restoring redox homeostasis, sGC activity, and NO sensitivity.

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Crossref · 10.1172/jci29807

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Authors
Gladwin, M. T.
Affiliations
National Institutes of Health (US)
Corresponding author
Gladwin, Mark T.
Venue
Journal of Clinical Investigation
Published
2006-09-01
Volume
116
Issue
9
Pages
2330-2332
ISSN
0021-9738 (ISSN-L)
OpenAlex
W1986547098
Cited by
85
References
22
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 7 · 2012: 4
FWCI
3.09
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
endothelial dysfunction, soluble guanylate cyclase, BAY 58-2667, nitric oxide resistance, nitric oxide signaling, redox homeostasis, diabetes mellitus, vasodilation
MeSH terms
Soluble Guanylyl Cyclase, Animals, Benzoates, Endothelium, Vascular, Cyclic GMP, Guanylate Cyclase, Humans, Nitric Oxide, Oxidation-Reduction, Vasodilation, Receptors, Cytoplasmic and Nuclear

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