The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo
Open accessAbstract
NO plays critical roles in vascular function. We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo. Transgenic mice expressing only a phosphomimetic (S1179D) form of eNOS show greater vascular reactivity, develop less severe strokes, and have improved cerebral blood flow in a middle cerebral artery occlusion model than mice expressing an unphosphorylatable (S1179A) form. These results provide a molecular mechanism by which multiple diverse cardiovascular risks, such as diabetes and obesity, may be centrally integrated by eNOS phosphorylation in vivo to influence blood flow and cardiovascular disease. They also demonstrate the in vivo relevance of posttranslational modification of eNOS in vascular function.
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Nitric oxide synthases: structure, function and inhibition
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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
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Hypertension in mice lacking the gene for endothelial nitric oxide synthase
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Self-citationMcCabe, T. J., Fulton, D., Roman, L. J., & Sessa, W. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6123 · Cited by 387
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Cited by
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
Balligand, J.-L., Feron, O., & Dessy, C. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2007 · Cited by 477
Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383
Protective effects and mechanisms of sirtuins in the nervous system
Zhang, F., Wang, S., Gan, L., Vosler, P. S., Gao, Y., Zigmond, M. J., & Chen, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.09.001 · Cited by 211
eNOS phosphorylation in health and disease
Kolluru, G. K., Siamwala, J. H., & Chatterjee, S. (2010) · Biochimie · doi:10.1016/j.biochi.2010.03.020 · Cited by 183
Metadata
- Authors
- Atochin, D. N., Wang, A., Liu, V. W. T., Critchlow, J. D., Dantas, A. P. V., Looft-Wilson, R., Murata, T., Salomone, S., Shin, H. K., Ayata, C., Moskowitz, M. A., Michel, T., Sessa, W. C., & Huang, P. L.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-07-02
- Volume
- 117
- Issue
- 7
- Pages
- 1961-1967
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2129753448
- Cited by
- 168
- References
- 5
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Atochin, D. N., Wang, A., Liu, V. W. T., Critchlow, J. D., Dantas, A. P. V., Looft-Wilson, R., Murata, T., Salomone, S., Shin, H. K., Ayata, C., Moskowitz, M. A., Michel, T., Sessa, W. C., & Huang, P. L. (2007). The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. Journal of Clinical Investigation. https://doi.org/10.1172/jci29877
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
