The microbiome and cancer

Hallmarks of Cancer: The Next Generation

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An obesity-associated gut microbiome with increased capacity for energy harvest

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Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works

Immunity, Inflammation, and Cancer

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Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Diversity of the Human Intestinal Microbial Flora

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Inflammation and cancer: back to Virchow?

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Obesity alters gut microbial ecology

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Host-Bacterial Mutualism in the Human Intestine

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Metagenomic Analysis of the Human Distal Gut Microbiome

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Richness of human gut microbiome correlates with metabolic markers

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Interactions Between the Microbiota and the Immune System

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Duodenal Infusion of Donor Feces for Recurrent <i>Clostridium difficile</i>

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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

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Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

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Bacterial Community Variation in Human Body Habitats Across Space and Time

Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · see citing works

The skin microbiome

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The gut flora as a forgotten organ

O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791 · see citing works

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

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Genetics and pathogenesis of inflammatory bowel disease

Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,630 · see citing works

Human nutrition, the gut microbiome and the immune system

Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476 · see citing works

MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT

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Intestinal inflammation targets cancer-inducing activity of the microbiota

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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

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Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori

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Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

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<i>Fusobacterium nucleatum</i> infection is prevalent in human colorectal carcinoma

Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · see citing works

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025 · see citing works

The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon

Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · see citing works

Genomic analysis identifies association of <i>Fusobacterium</i> with colorectal carcinoma

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Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

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TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

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Dietary intervention impact on gut microbial gene richness

Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works

Helicobacter pylori and gastrointestinal tract adenocarcinomas

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The keystone-pathogen hypothesis

Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790 · see citing works

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

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An ecological and evolutionary perspective on human–microbe mutualism and disease

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Oncogenically active MYD88 mutations in human lymphoma

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Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China

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Skin immune sentinels in health and disease

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Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

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Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

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Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae

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Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

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Gut immune maturation depends on colonization with a host-specific microbiota

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Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

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Filaggrin Mutations Associated with Skin and Allergic Diseases

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<i>Escherichia coli</i> Induces DNA Double-Strand Breaks in Eukaryotic Cells

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Antioxidant activity of fresh apples

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Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

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Cancer prevention by tea: animal studies, molecular mechanisms and human relevance

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Molecular mechanisms of alcohol-mediated carcinogenesis

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Moving pictures of the human microbiome

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Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

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Th17 and regulatory T cells in mediating and restraining inflammation

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Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer

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Host-Derived Nitrate Boosts Growth of <i>E. coli</i> in the Inflamed Gut

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The genetics and immunopathogenesis of inflammatory bowel disease

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Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2

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<i>Escherichia coli</i> induces DNA damage in vivo and triggers genomic instability in mammalian cells

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Microbial Dysbiosis in Colorectal Cancer (CRC) Patients

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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

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Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

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High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health

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Inflammation, atrophy, and gastric cancer

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Why do viruses cause cancer? Highlights of the first century of human tumour virology

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Microbiome and malignancy

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Relevance of protein fermentation to gut health

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Regulated virulence controls the ability of a pathogen to compete with the gut microbiota

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Cancer epidemiology in the last century and the next decade

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Bacterial translocation (BT) in cirrhosis†

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Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer

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Phyto-oestrogens and cancer

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New concepts in the generation and functions of IgA

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Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors

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Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

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Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88

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NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

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Nod2 is required for the regulation of commensal microbiota in the intestine

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Inflammation and colorectal cancer: colitis-associated neoplasia

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Microbial pathways in colonic sulfur metabolism and links with health and disease

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Metabolic fate of polyphenols in the human superorganism

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High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

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NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

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