The DOI matches its Crossref record; 126 of the 128 references it cites were found in a registry or an index.
Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
Open accessAbstract
Models of liver fibrosis, which include cell culture models, explanted and biopsied human material, and experimental animal models, have demonstrated that liver fibrosis is a highly dynamic example of solid organ wound healing. Recent work in human and animal models has shown that liver fibrosis is potentially reversible and, in specific circumstances, demonstrates resolution with a restoration of near normal architecture. This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ.
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“In fibrotic diseases it has been shown that the accumulation of ECM components can be driven primarily by inflammatory processes [59].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [59]
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Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,687
Molecular and cellular mechanisms of liver fibrosis and its regression
Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
Anstee, Q. M., Targher, G., & Day, C. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.41 · Cited by 1,747
Metadata
- Authors
- Iredale, J. P.
- Affiliations
- Centre for Inflammation Research (GB)
- Corresponding author
- Iredale, John P.
- ORCID
- Iredale, John P.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-03-01
- Volume
- 117
- Issue
- 3
- Pages
- 539-548
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1804370
- OpenAlex
- W2120335459
- Cited by
- 866
- References
- 128
- Citations by year
- 2026: 19 · 2025: 40 · 2024: 45 · 2023: 39 · 2022: 32 · 2021: 39 · 2020: 34 · 2019: 36 · 2018: 39 · 2017: 36 · 2016: 51 · 2015: 63 · 2014: 61 · 2013: 57 · 2012: 55
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Children's Liver Disease Foundation
- Medical Research Council
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- liver fibrosis, wound healing, inflammation, tissue repair, animal models, cell culture model, liver regeneration
- MeSH terms
- Animals, Disease Models, Animal, Extracellular Matrix, Fibroblasts, Humans, Inflammation, Liver Cirrhosis, Liver Cirrhosis, Experimental, Liver Regeneration, Models, Biological, Wound Healing
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