Cited by 866Liver physiology and pathologyWound Healing and TreatmentsLiver Disease Diagnosis and Treatment

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Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

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Iredale, John P.·2007·Journal of Clinical Investigation

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Abstract

Models of liver fibrosis, which include cell culture models, explanted and biopsied human material, and experimental animal models, have demonstrated that liver fibrosis is a highly dynamic example of solid organ wound healing. Recent work in human and animal models has shown that liver fibrosis is potentially reversible and, in specific circumstances, demonstrates resolution with a restoration of near normal architecture. This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ.

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Authors: Iredale, J. P.
Affiliations: Centre for Inflammation Research (GB)
Corresponding author: Iredale, John P.
ORCID: Iredale, John P.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-03-01
Volume: 117
Issue: 3
Pages: 539-548
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci30542
PMC: PMC1804370
OpenAlex: W2120335459
Cited by: 866
References: 128
Citations by year: 2026: 19 · 2025: 40 · 2024: 45 · 2023: 39 · 2022: 32 · 2021: 39 · 2020: 34 · 2019: 36 · 2018: 39 · 2017: 36 · 2016: 51 · 2015: 63 · 2014: 61 · 2013: 57 · 2012: 55
FWCI: 7.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders: Wellcome Trust
Children's Liver Disease Foundation
Medical Research Council
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: liver fibrosis, wound healing, inflammation, tissue repair, animal models, cell culture model, liver regeneration
MeSH terms: Animals, Disease Models, Animal, Extracellular Matrix, Fibroblasts, Humans, Inflammation, Liver Cirrhosis, Liver Cirrhosis, Experimental, Liver Regeneration, Models, Biological, Wound Healing

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Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

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