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Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.
Open accessAbstract
The mRNA levels for the mitochondrial uncoupling protein (UCP1) in fat tissues of A/J and C57BL/6J inbred strains of mice varied in a regional-specific manner after stimulation of adrenergic signaling by cold exposure or treatment with a beta3-adrenergic agonist. While the differences between strains were minimal in interscapular brown fat, large differences occurred in white fat tissues, particularly in retroperitoneal fat. Among the AXB recombinant inbred strains, the Ucp1 mRNA levels varied up to 130-fold. This large induction at the mRNA level was accompanied by a corresponding increase in brown adipocytes as revealed by immunohistology with anti-UCP1 antibodies. A high capacity to induce brown fat in areas of traditional white fat had no impact on the ability to gain weight in response to high fat and sucrose diets, but did correlate with the loss of weight in response to treatment with a beta3-adrenergic agonist (CL 316,243). This genetic variation in mice provides an experimental approach to identify genes controlling the induction of brown adipocytes in white fat tissues.
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“Induction of BAT in mice promotes energy expenditure, reduces adiposity, and protects mice from diet-induced obesity 73,74.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [74]
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“These systemic brown adipocytes are often found admixed with white fat cells; are more sensitive to β3-adrenergic stimulation and cold exposure; and their thermogenic capacity appears to be regulated by genetic background 86,87,74.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [74]
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Metadata
- Authors
- Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P.
- Affiliations
- Jackson Laboratory (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1998-07-15
- Volume
- 102
- Issue
- 2
- Pages
- 412-420
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508900
- OpenAlex
- W2025530025
- Cited by
- 635
- References
- 45
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 19 · 2021: 28 · 2020: 25 · 2019: 36 · 2018: 38 · 2017: 43 · 2016: 43 · 2015: 52 · 2014: 51 · 2013: 53 · 2012: 37
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- brown adipocytes, white adipose tissue, UCP1, mitochondrial uncoupling proteins, genetic variation, inbred mouse strains, recombinant inbred lines, beta3-adrenergic agonists, CL316,243, cold exposure, adrenergic signaling, retroperitoneal fat, interscapular brown fat, weight gain, high-fat diet, adiposity
- MeSH terms
- Uncoupling Protein 1, Animals, Body Weight, Adipose Tissue, Brown, Carrier Proteins, Cell Differentiation, Gene Expression Regulation, Ion Channels, Male, Membrane Proteins, Mice, Inbred C57BL, Obesity, RNA, Messenger, Adipocytes, Mitochondrial Proteins, Mice
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