Cited by 635Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

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Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

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Guerra, C, Koza, R A, Yamashita, H, Walsh, K, Kozak, L P·1998·Journal of Clinical Investigation

DOI 10.1172/jci3155PMC PMC508900

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Abstract

The mRNA levels for the mitochondrial uncoupling protein (UCP1) in fat tissues of A/J and C57BL/6J inbred strains of mice varied in a regional-specific manner after stimulation of adrenergic signaling by cold exposure or treatment with a beta3-adrenergic agonist. While the differences between strains were minimal in interscapular brown fat, large differences occurred in white fat tissues, particularly in retroperitoneal fat. Among the AXB recombinant inbred strains, the Ucp1 mRNA levels varied up to 130-fold. This large induction at the mRNA level was accompanied by a corresponding increase in brown adipocytes as revealed by immunohistology with anti-UCP1 antibodies. A high capacity to induce brown fat in areas of traditional white fat had no impact on the ability to gain weight in response to high fat and sucrose diets, but did correlate with the loss of weight in response to treatment with a beta3-adrenergic agonist (CL 316,243). This genetic variation in mice provides an experimental approach to identify genes controlling the induction of brown adipocytes in white fat tissues.

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Authors: Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P.
Affiliations: Jackson Laboratory (US)
ORCID: Guerra, C
Koza, R A
Yamashita, H
Kozak, L P
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1998-07-15
Volume: 102
Issue: 2
Pages: 412-420
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci3155
PMC: PMC508900
OpenAlex: W2025530025
Cited by: 635
References: 45
Citations by year: 2026: 5 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 19 · 2021: 28 · 2020: 25 · 2019: 36 · 2018: 38 · 2017: 43 · 2016: 43 · 2015: 52 · 2014: 51 · 2013: 53 · 2012: 37
FWCI: 5.33
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: brown adipocytes, white adipose tissue, UCP1, mitochondrial uncoupling proteins, genetic variation, inbred mouse strains, recombinant inbred lines, beta3-adrenergic agonists, CL316,243, cold exposure, adrenergic signaling, retroperitoneal fat, interscapular brown fat, weight gain, high-fat diet, adiposity
MeSH terms: Uncoupling Protein 1, Animals, Body Weight, Adipose Tissue, Brown, Carrier Proteins, Cell Differentiation, Gene Expression Regulation, Ion Channels, Male, Membrane Proteins, Mice, Inbred C57BL, Obesity, RNA, Messenger, Adipocytes, Mitochondrial Proteins, Mice

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Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

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