The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Adoptive T cell therapy for cancer in the clinic
Open accessAbstract
The transfusion of lymphocytes, referred to as adoptive T cell therapy, is being tested for the treatment of cancer and chronic infections.Adoptive T cell therapy has the potential to enhance antitumor immunity, augment vaccine efficacy, and limit graft-versus-host disease.This form of personalized medicine is now in various early-and late-stage clinical trials.These trials are currently testing strategies to infuse tumor-infiltrating lymphocytes, CTLs, Th cells, and Tregs.Improved molecular biology techniques have also increased enthusiasm and feasibility for testing genetically engineered T cells.The current status of the field and prospects for clinical translation are reviewed herein.Nonstandard abbreviations used: DLI, donor lymphocyte infusion; GVHD, graftversus-host disease; HSV-TK, herpes simplex virus thymidine kinase; MART-1, melanoma-associated antigen recognized by T cells 1; TIL, tumor-infiltrating lymphocyte.Conflict of interest: C.H. June receives income from BD Biosciences, Cell Genesys, CellDex Therapeutics, Maxcyte, and AVEO Pharmaceuticals Inc. and research sup-
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Metadata
- Authors
- June, C. H.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-06-01
- Volume
- 117
- Issue
- 6
- Pages
- 1466-1476
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2141262236
- Cited by
- 553
- References
- 112
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
