The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Adiponectin regulates albuminuria and podocyte function in mice
Open accessAbstract
Increased albuminuria is associated with obesity and diabetes and is a risk factor for cardiovascular and renal disease. However, the link between early albuminuria and adiposity remains unclear. To determine whether adiponectin, an adipocyte-derived hormone, is a communication signal between adipocytes and the kidney, we performed studies in a cohort of patients at high risk for diabetes and kidney disease as well as in adiponectin-knockout (Ad(-/-)) mice. Albuminuria had a negative correlation with plasma adiponectin in obese patients, and Ad(-/-) mice exhibited increased albuminuria and fusion of podocyte foot processes. In cultured podocytes, adiponectin administration was associated with increased activity of AMPK, and both adiponectin and AMPK activation reduced podocyte permeability to albumin and podocyte dysfunction, as evidenced by zona occludens-1 translocation to the membrane. These effects seemed to be caused by reduction of oxidative stress, as adiponectin and AMPK activation both reduced protein levels of the NADPH oxidase Nox4 in podocytes. Ad(-/-) mice treated with adiponectin exhibited normalization of albuminuria, improvement of podocyte foot process effacement, increased glomerular AMPK activation, and reduced urinary and glomerular markers of oxidant stress. These results suggest that adiponectin is a key regulator of albuminuria, likely acting through the AMPK pathway to modulate oxidant stress in podocytes.
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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
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Cited by
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Mechanisms of Diabetic Complications
Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890
Evolving importance of kidney disease: from subspecialty to global health burden
Eckardt, K.-U., Coresh, J., Devuyst, O., Johnson, R. J., Köttgen, A., Levey, A. S., & Levin, A. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60439-0 · Cited by 1,159
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Adiponectin: mechanistic insights and clinical implications
Turer, A. T., & Scherer, P. E. (2012) · Diabetologia · doi:10.1007/s00125-012-2598-x · Cited by 632
Metadata
- Authors
- Sharma, K., RamachandraRao, S., Qiu, G., Usui, H. K., Zhu, Y., Dunn, S. R., Ouedraogo, R., Hough, K., McCue, P., Chan, L., Falkner, B., & Goldstein, B. J.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-04-01
- Volume
- 118
- Issue
- 5
- Pages
- 1645-56
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2017073557
- Cited by
- 612
- References
- 8
- FWCI
- 29.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Sharma, K., RamachandraRao, S., Qiu, G., Usui, H. K., Zhu, Y., Dunn, S. R., Ouedraogo, R., Hough, K., McCue, P., Chan, L., Falkner, B., & Goldstein, B. J. (2008). Adiponectin regulates albuminuria and podocyte function in mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci32691
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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