The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice
Open accessAbstract
Endothelial dysfunction is a key triggering event in atherosclerosis. Following the entry of lipoproteins into the vessel wall, their rapid modification results in the generation of advanced glycation endproduct epitopes and subsequent infiltration of inflammatory cells. These inflammatory cells release receptor for advanced glycation endproduct (RAGE) ligands, specifically S100/calgranulins and high-mobility group box 1, which sustain vascular injury. Here, we demonstrate critical roles for RAGE and its ligands in vascular inflammation, endothelial dysfunction, and atherosclerotic plaque development in a mouse model of atherosclerosis, apoE-/- mice. Experiments in primary aortic endothelial cells isolated from mice and in cultured human aortic endothelial cells revealed the central role of JNK signaling in transducing the impact of RAGE ligands on inflammation. These data highlight unifying mechanisms whereby endothelial RAGE and its ligands mediate vascular and inflammatory stresses that culminate in atherosclerosis in the vulnerable vessel wall.
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Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
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Self-citationYONEKURA, H., YAMAMOTO, Y., SAKURAI, S., PETROVA, R. G., ABEDIN, M. J., LI, H., YASUI, K., TAKEUCHI, M., MAKITA, Z., TAKASAWA, S., et al. (2003) · Biochemical Journal · doi:10.1042/bj20021371 · Cited by 716
Cited by
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051
Damage-associated molecular patterns in inflammatory diseases
Roh, J. S., & Sohn, D. H. (2018) · Immune Network · doi:10.4110/in.2018.18.e27 · Cited by 1,261
Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956
Advanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751
Sterile inflammation in the liver
Kubes, P., & Mehal, W. Z. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.008 · Cited by 666
Metadata
- Authors
- Harja, E., Bu, D.-X., Hudson, B. I., Chang, J. S., Shen, X., Hallam, K., Kalea, A. Z., Lu, Y., Rosario, R. H., Oruganti, S., Nikolla, Z., Belov, D., Lalla, E., Ramasamy, R., Yan, S. F., & Schmidt, A. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-01-02
- Volume
- 118
- Issue
- 1
- Pages
- 183-194
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2114688115
- Cited by
- 364
- References
- 4
- FWCI
- 20.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice. https://app.cochat.ai/papers/10.1172/jci32703
- The paper
- Harja, E., Bu, D.-X., Hudson, B. I., Chang, J. S., Shen, X., Hallam, K., Kalea, A. Z., Lu, Y., Rosario, R. H., Oruganti, S., Nikolla, Z., Belov, D., Lalla, E., Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2008). Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci32703
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
