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Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice
Open accessAbstract
Endothelial dysfunction is a key triggering event in atherosclerosis. Following the entry of lipoproteins into the vessel wall, their rapid modification results in the generation of advanced glycation endproduct epitopes and subsequent infiltration of inflammatory cells. These inflammatory cells release receptor for advanced glycation endproduct (RAGE) ligands, specifically S100/calgranulins and high-mobility group box 1, which sustain vascular injury. Here, we demonstrate critical roles for RAGE and its ligands in vascular inflammation, endothelial dysfunction, and atherosclerotic plaque development in a mouse model of atherosclerosis, apoE-/- mice. Experiments in primary aortic endothelial cells isolated from mice and in cultured human aortic endothelial cells revealed the central role of JNK signaling in transducing the impact of RAGE ligands on inflammation. These data highlight unifying mechanisms whereby endothelial RAGE and its ligands mediate vascular and inflammatory stresses that culminate in atherosclerosis in the vulnerable vessel wall.
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Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217
Self-citationYONEKURA, H., YAMAMOTO, Y., SAKURAI, S., PETROVA, R. G., ABEDIN, M. J., LI, H., YASUI, K., TAKEUCHI, M., MAKITA, Z., TAKASAWA, S., et al. (2003) · Biochemical Journal · doi:10.1042/bj20021371 · Cited by 716
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Roh, J. S., & Sohn, D. H. (2018) · Immune Network · doi:10.4110/in.2018.18.e27 · Cited by 1,261
Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956
Advanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751
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Kubes, P., & Mehal, W. Z. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.008 · Cited by 666
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Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06320.x · Cited by 521
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Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., et al. (2008) · Diabetes · doi:10.2337/db07-1808 · Cited by 407
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Yan, S. F., Ramasamy, R., & Schmidt, A. M. (2010) · Circulation Research · doi:10.1161/circresaha.109.212217 · Cited by 381
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Bongarzone, S., Savickas, V., Luzi, F., & Gee, A. D. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00058 · Cited by 313
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Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0409230 · Cited by 283
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Simats, A., & Liesz, A. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202216269 · Cited by 276
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells
Ma, L., Sun, P., Zhang, J.-C., Zhang, Q., & Yao, S.-L. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2987 · Cited by 196
Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes
Funk, S. D., Yurdagul, A., & Orr, A. W. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/569654 · Cited by 176
Hofmann Bowman, M. A., Gawdzik, J., Bukhari, U., Husain, A. N., Toth, P. T., Kim, G., Earley, J., & McNally, E. M. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.110.217745 · Cited by 111
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Novák, J., Olejníčková, V., Tkáčová, N., & Santulli, G. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-22380-3_5 · Cited by 95
Prantner, D., Nallar, S., & Vogel, S. N. (2020) · The FASEB Journal · doi:10.1096/fj.202002136r · Cited by 92
Sahara, M., Ikutomi, M., Morita, T., Minami, Y., Nakajima, T., Hirata, Y., Nagai, R., & Sata, M. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvt245 · Cited by 74
Liu, M., Yu, Y., Jiang, H., Zhang, L., Zhang, P.-P., Yu, P., Jia, J.-G., Chen, R.-Z., Zou, Y.-Z., & Ge, J.-B. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.8 · Cited by 69
Li, F., Cai, Z., Chen, F., Shi, X., Zhang, Q., Chen, S., Shi, J., Wang, D. W., & Dong, N. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0306-0 · Cited by 67
Ueno, H., Koyama, H., Shoji, T., Monden, M., Fukumoto, S., Tanaka, S., Otsuka, Y., Mima, Y., Morioka, T., Mori, K., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.04.006 · Cited by 65
RAGE Does Not Affect Amyloid Pathology in Transgenic ArcAβ Mice
Vodopivec, I., Galichet, A., Knobloch, M., Bierhaus, A., Heizmann, C. W., & Nitsch, R. M. (2009) · Neurodegenerative Diseases · doi:10.1159/000261723 · Cited by 23
Metadata
- Authors
- Harja, E., Bu, D.-X., Hudson, B. I., Chang, J. S., Shen, X., Hallam, K., Kalea, A. Z., Lu, Y., Rosario, R. H., Oruganti, S., Nikolla, Z., Belov, D., Lalla, E., Ramasamy, R., Yan, S. F., & Schmidt, A. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-01-02
- Volume
- 118
- Issue
- 1
- Pages
- 183-194
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2114688115
- Cited by
- 364
- References
- 4
- FWCI
- 20.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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