The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Defects in induction, maturation, or lysosomal clearance impair protein degradation (Zhong et al. 2009), (Pickford et al. 2008), (Ravikumar et al. 2005), (Webb et al. 2004), (Iwata et al. 2005), (Kimura et al. 2008), (Wong and Cuervo 2010), (Lee et al. 2010), and is assessable via LC3-II turnover or p62 degradation (Mizushima et al. 2010), (Ju et al. 2010), (Klionsky et al. 2008b), (Tanida et al.”
From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Pickford et al. 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Self-citationHow to Interpret LC3 Immunoblotting
Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595 · cited 4×
“While LC3-I is present in the cytosol, the lipidated LC3-II form is associated mainly with autophagosomal membranes, serving as a good indicator of autophagosomes (32, 33).”
BackgroundInfluentialSynapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311
Self-citationYue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116
Intracellular amyloid-β in Alzheimer's disease
LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942
Flagged first, then by citations
Research works printed but not linked: 50
- 10.1016/S0166-2236(96)01030-2 · DOI · Paper page
- 10.1016/S0962-8924(00)01852-3 · DOI
- 10.1097/00001756-200411150-00001 · DOI
- Levine, 2005, Cell., 120, 159
- 10.1083/jcb.200505082 · DOI · Paper page
- 10.1038/nature04723 · DOI · Paper page
- 10.1126/science.290.5497.1717 · DOI
- Eskelinen, 2005, Autophagy., 1, 1, 10.4161/auto.1.1.1270 · DOI · Paper page
- 10.1016/S0896-6273(02)00861-9 · DOI · Paper page
- 10.1038/cr.2007.78 · DOI · Paper page
- 10.1242/jcs.02735 · DOI
- Liang, 1998, J. Virol., 72, 8586, 10.1128/JVI.72.11.8586-8596.1998 · DOI
- Chu, 2007, Autophagy., 3, 663, 10.4161/auto.4625 · DOI
- 10.1001/archneur.63.5.665 · DOI · Paper page
- 10.1089/neu.2005.22.750 · DOI
- 10.1023/B:NERE.0000023601.50101.7f · DOI
- 10.1002/ana.20667 · DOI · Paper page
- Mucke, 2000, J. Neurosci., 20, 4050, 10.1523/JNEUROSCI.20-11-04050.2000 · DOI · Paper page
- 10.1002/jnr.1247 · DOI
- 10.1091/mbc.E03-09-0704 · DOI · Paper page
- Nixon, 2005, J. Neuropathol. Exp. Neurol., 64, 113, 10.1093/jnen/64.2.113 · DOI · Paper page
- de Villiers, 1999, J. Leukoc. Biol., 66, 740, 10.1002/jlb.66.5.740 · DOI
- 10.1042/0264-6021:3380687 · DOI
- 10.1097/00005072-200606000-00007 · DOI
- 10.1006/exnr.1997.6772 · DOI
- 10.1002/ana.410300410 · DOI · Paper page
- Masliah, 2001, Neurology., 56, 127, 10.1212/WNL.56.1.127 · DOI · Paper page
- 10.1016/0006-8993(96)00081-9 · DOI · Paper page
- 10.1073/pnas.0509695103 · DOI · Paper page
- 10.1073/pnas.1133381100 · DOI · Paper page
- Irizarry, 1997, J. Neurosci., 17, 7053, 10.1523/JNEUROSCI.17-18-07053.1997 · DOI · Paper page
- 10.1073/pnas.87.10.3861 · DOI · Paper page
- 10.1016/j.cell.2005.07.002 · DOI · Paper page
- Furuya, 2005, Autophagy., 1, 46, 10.4161/auto.1.1.1542 · DOI
- 10.1038/ncb1426 · DOI · Paper page
- 10.1016/j.neurobiolaging.2003.04.007 · DOI
- 10.1016/S0896-6273(01)00496-2 · DOI · Paper page
- 10.1038/ng1591 · DOI · Paper page
- 10.1083/jcb.200406060 · DOI
- 10.1083/jcb.200403061 · DOI
- 10.1023/A:1007675508413 · DOI
- 10.1212/01.wnl.0000192107.17175.39 · DOI
- 10.1002/ana.410320304 · DOI
- Buttini, 1999, J. Neurosci., 19, 4867, 10.1523/JNEUROSCI.19-12-04867.1999 · DOI
- 10.1016/S0896-6273(03)00766-9 · DOI · Paper page
- 10.1038/39321 · DOI · Paper page
- Everall, 1999, Brain Pathol., 9, 209, 10.1111/j.1750-3639.1999.tb00219.x · DOI
- 10.1073/pnas.96.22.12893 · DOI
- Masliah, 1996, J. Neurosci., 16, 5795, 10.1523/JNEUROSCI.16-18-05795.1996 · DOI
- Marr, 2003, J. Neurosci., 23, 1992, 10.1523/JNEUROSCI.23-06-01992.2003 · DOI
Cited by
Sorted by citations
Items 101–104 of 104
A new method to measure autophagy flux in the nervous system
Matus, S., Valenzuela, V., & Hetz, C. (2014) · Autophagy · doi:10.4161/auto.28434 · Cited by 29
Elbaz, E. M., Ibrahim, S. M., Rashad, E., Yasin, N. A. E., Ghaiad, H. R., & Mehana, N. A. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00351 · Cited by 21
Moussa, C. E.-H. (2015) · Neurodegenerative Diseases · doi:10.1159/000430888 · Cited by 13
TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models
Roy, B., Contu, V. R., Jeziorek, M., Friedman, W. J., & Wong, C.-O. (2026) · doi:10.64898/2026.10.21.760809
Metadata
- Authors
- Pickford, F., Masliah, E., Britschgi, M., Lucin, K., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., & Wyss-Coray, T.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-05-01
- ISSN
- 0021-9738
- Cited by
- 268
- References
- 17
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
