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Loss of TGF-β1 Leads to Increased Neuronal Cell Death and Microgliosis in Mouse Brain

Brionne, Thomas C, Tesseur, Ina, Masliah, Eliezer, Wyss-Coray, Tony·2003·Neuron

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Crossref · 10.1016/s0896-6273(03)00766-9

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  • Loss of TGF-β1 in Tgfb1−/− mice leads to increased neuronal cell death and microgliosis in the brain.

    “Tgfb1−/− animals die at 3 weeks of age of a severe multifocal autoinflammatory disorder30 and it has been reported that the loss of TGF-β1 in these mice leads to increased neuronal cell death and microgliosis in the brain47.”

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Cites

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Research works printed but not linked: 5

  1. Fadok, V.A., Bratton, D.L., Rose, D.M., Pearson, A., Ezekewitz, R.A.B., and Henson, P.M. (2000). A receptor for phosphatidylserine- Letterio, J.J., and Roberts, A.B. (1997). TGF-beta: a critical modula- specific clearance of apoptotic cells. Nature 405, 85-90. tor of immune cell function. Clin. Immunol. Immunopathol. 84, 244-250.
  2. Geiser, A.G., Letterio, J.J., Kulkarni, A.B., Karlsson, S., Roberts, Luckenbill-Edds, L. (1997). Laminin and the mechanism of neuronal A.B., and Sporn, M.B. (1993). Transforming growth factor ␤ 1 (TGF-␤ 1 ) outgrowth. Brain Res. Brain Res. Rev. 23, 1-27. controls expression of major histocompatibility genes in the postna- tal mouse: Aberrant histocompatibility antigen expression in the Masliah, E., Achim, C.L., Ge, N., DeTeresa, R., Terry, R.D., and Wiley, pathogenesis of the TGF-␤ 1 null mouse phenotype. Proc. Natl. Acad.
  3. Gleeson, J.G., Allen, K.M., Fox, J.W., Lamperti, E.D., Berkovic, S., Masliah, E., Ge, N., Morey, M., DeTeresa, R., Terry, R.D., and Wiley, Scheffer, I., Cooper, E.C., Dobyns, W.B., Minnerath, S.R., Ross, M.E., C.A. (1992b). Cortical dendritic pathology in human immunodefi- and Walsh, C.A. (1998). Doublecortin, a brain-specific gene mutated ciency virus encephalitis. Lab. Invest. 66, 285-291.
  4. Jones, K.R., Farinas, I., Backus, C., and Reichardt, L.F. (1994). Tar- geted disruption of the BDNF gene perturbs brain and sensory neu- Roberts, A.B., and Sporn, M.B. (1996). Transforming growth factor-␤. ron development but not motor neuron development. Cell 76, In The Molecular and Cellular Biology of Wound Repair, R.A.F. Clark, 989-999. ed. (New York: Plenum Press), pp. 275-308.
  5. Schauwecker, P.E., and Steward, O. (1997). Genetic determinants 10, 1492-1497. of susceptibility to excitotoxic cell death: Implications for gene tar- Krieglstein, K., Reuss, B., Maysinger, D., and Unsicker, K. (1998). geting approaches. Proc. Natl. Acad. Sci. USA 94, 4103-4108. Transforming growth factor-␤ mediates the neurotrophic effect of Schober, A., Hertel, R., Aruma ¨e, U., Farkas, L., Jaszai, J., and fibroblast growth factor-2 on midbrain dopaminergic neurons. Eur.

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