The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
Open accessAbstract
Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore investigated the association of fasting glucose levels with SNPs in 2 genome-wide scans including a total of 5,088 nondiabetic individuals from Finland and Sardinia. We found a significant association between the SNP rs563694 and fasting glucose concentrations (P = 3.5 x 10(-7)). This association was further investigated in an additional 18,436 nondiabetic individuals of mixed European descent from 7 different studies. The combined P value for association in these follow-up samples was 6.9 x 10(-26), and combining results from all studies resulted in an overall P value for association of 6.4 x 10(-33). Across these studies, fasting glucose concentrations increased 0.01-0.16 mM with each copy of the major allele, accounting for approximately 1% of the total variation in fasting glucose. The rs563694 SNP is located between the genes glucose-6-phosphatase catalytic subunit 2 (G6PC2) and ATP-binding cassette, subfamily B (MDR/TAP), member 11 (ABCB11). Our results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation.
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Cites
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Self-citationA genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
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Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
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Self-citationNewly identified loci that influence lipid concentrations and risk of coronary artery disease
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Cited by
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166
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Self-citationVariants in MTNR1B influence fasting glucose levels
Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Thorleifsson, G., Loos, R. J. F., Manning, A. K., Jackson, A. U., Aulchenko, Y., et al. (2009) · Nature Genetics · doi:10.1038/ng.290 · Cited by 744
Self-citationPractical aspects of imputation-driven meta-analysis of genome-wide association studies
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Metabolic syndrome: from epidemiology to systems biology
Lusis, A. J., Attie, A. D., & Reue, K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2468 · Cited by 344
Metadata
- Authors
- Chen, W.-M., Erdos, M. R., Jackson, A. U., Saxena, R., Sanna, S., Silver, K. D., Timpson, N. J., Hansen, T., Orrù, M., Grazia Piras, M., Bonnycastle, L. L., Willer, C. J., Lyssenko, V., Shen, H., Kuusisto, J., Ebrahim, S., Sestu, N., Duren, W. L., Spada, M. C., Stringham, H. M., Scott, L. J., Olla, N., Swift, A. J., Najjar, S., Mitchell, B. D., Lawlor, D. A., Smith, G. D., Ben-Shlomo, Y., Andersen, G., Borch-Johnsen, K., Jørgensen, T., Saramies, J., Valle, T. T., Buchanan, T. A., Shuldiner, A. R., Lakatta, E., Bergman, R. N., Uda, M., Tuomilehto, J., Pedersen, O., Cao, A., Groop, L., Mohlke, K. L., Laakso, M., Schlessinger, D., Collins, F. S., Altshuler, D., Abecasis, G. R., Boehnke, M., Scuteri, A., & Watanabe, R. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-06-01
- Volume
- 118
- Issue
- 7
- Pages
- 2620-8
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2119706813
- Cited by
- 178
- References
- 11
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. https://app.cochat.ai/papers/10.1172/jci34566
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- Chen, W.-M., Erdos, M. R., Jackson, A. U., Saxena, R., Sanna, S., Silver, K. D., Timpson, N. J., Hansen, T., Orrù, M., Grazia Piras, M., Bonnycastle, L. L., Willer, C. J., Lyssenko, V., Shen, H., Kuusisto, J., Ebrahim, S., Sestu, N., Duren, W. L., Spada, M. C., . . . Watanabe, R. M. (2008). Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. Journal of Clinical Investigation. https://doi.org/10.1172/jci34566
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