The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
Open accessAbstract
Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflammation to systemic metabolic consequences are not fully understood. In this study, we have taken advantage of the highly restricted coexpression of adipocyte/macrophage fatty acid-binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and systemic inflammation and metabolic homeostasis in mice. Deletion of FABPs in adipocytes resulted in reduced expression of inflammatory cytokines in macrophages, whereas the same deletion in macrophages led to enhanced insulin signaling and glucose uptake in adipocytes. Using radiation chimerism through bone marrow transplantation, we generated mice with FABP deficiency in bone marrow and stroma-derived elements in vivo and studied the impact of each cellular target on local and systemic insulin action and glucose metabolism in dietary obesity. The results of these experiments indicated that neither macrophages nor adipocytes individually could account for the total impact of FABPs on systemic metabolism and suggest that interactions between these 2 cell types, particularly in adipose tissue, are critical for the inflammatory basis of metabolic deterioration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · cited 1×
“Similarly, specific and isolated deletion of target genes in the myeloid lineage has also produced support for the hypothesis that these cells impact systemic metabolic homeostasis (8, 9).”
BackgroundConditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
Furuhashi, M., & Hotamışlıgil, G. S. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2589 · Cited by 1,811
Self-citationIKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Research works printed but not linked: 2
- Wellen, 2005, J. Clin. Invest., 115, 1111, 10.1172/JCI200525102 · DOI · Paper page
- 10.1210/en.141.9.3388 · DOI
Cited by
Sorted by citations
Items 101–200 of 330
Yu, D. C. W., Liang, X., Lipsky, S., Karaaslan, Ç., Kozakewich, H. P., Hotamışlıgil, G. S., Bischoff, J. E., & Çataltepe, S. (2015) · Angiogenesis · doi:10.1007/s10456-015-9491-4 · Cited by 62
Regeneration of the Endothelium in Vascular Injury
Vanhoutte, P. M. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6257-5 · Cited by 60
Wang, M., Luo, L., Yao, L., Wang, C., Jiang, K., Liu, X., Xu, M., Shen, N., Guo, S., Sun, C., et al. (2016) · Scientific Reports · doi:10.1038/srep25399 · Cited by 62
Apaya, M. K., Hsiao, P., Yang, Y., & Shyur, L. (2020) · Cancers · doi:10.3390/cancers12010199 · Cited by 60
Tanaka, M., Mori, K., Takahashi, S., Higashiura, Y., Ohnishi, H., Hanawa, N., & Furuhashi, M. (2022) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfac188 · Cited by 59
Self-citationThe 2009 Stock Conference Report: Inflammation, Obesity and Metabolic Disease
Hevener, A. L., Febbraio, M. A., & the Stock Conference Working Group (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00691.x · Cited by 60
The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches
Shook, B. A., Rivera-Gonzalez, G. C., Ebmeier, S., Grisotti, G., Zwick, R. K., & Horsley, V. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125426 · Cited by 59
Chen, J., Liu, X., Zhang, S., Chen, J., Sun, H., Zhang, L., & Zhang, Q. (2019) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp05704h · Cited by 58
García‐Vega, D., Sánchez-López, D., Rodríguez-Carnero, G., Villar‐Taibo, R., Viñuela, J. E., Lestegás-Soto, A., Seoane‐Blanco, A., Moure‐González, M., Bravo, S. B., Fernández, Á. L., et al. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02096-9 · Cited by 62
Bartelt, A., Beil, F. T., Schinke, T., Roeser, K., Ruether, W., Heeren, J., & Niemeier, A. (2010) · Bone · doi:10.1016/j.bone.2010.07.002 · Cited by 57
Genotype–phenotype interactions in pediatric obstructive sleep apnea
Gozal, D., & Gozal, D. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2013.03.016 · Cited by 57
Furuhashi, M., Hiramitsu, S., Mita, T., Fuseya, T., Ishimura, S., Omori, A., Matsumoto, M., Watanabe, Y. S., Hoshina, K., Tanaka, M., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m059469 · Cited by 56
Self-citationYang, R. S., Castriota, G. A., Chen, Y., Cleary, M. A., Ellsworth, K. P., Shin, M. K., Tran, J.-L., Vogt, T., Wu, M. S., Xu, S., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.128 · Cited by 55
Bao, Y., Lu, Z., Zhou, M., Li, H., Wang, Y., Gao, M., Wei, M., & Jia, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019115 · Cited by 53
Bhushan, B., Khalyfa, A., Spruyt, K., Gozal, D., Capdevila, Ó. S., Bhattacharjee, R., Kim, J., Keating, B. J., Hakonarson, H. H., & Gozal, D. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.12.014 · Cited by 54
Reduction of circulating FABP4 level by treatment with omega-3 fatty acid ethyl esters
Furuhashi, M., Hiramitsu, S., Mita, T., Omori, A., Fuseya, T., Ishimura, S., Watanabe, Y. S., Hoshina, K., Matsumoto, M., Tanaka, M., et al. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0177-8 · Cited by 54
Self-citationStaines, K. A., Zhu, D., Farquharson, C., & MacRae, V. E. (2013) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-013-0493-2 · Cited by 52
Furuhashi, M., Mita, T., Moniwa, N., Hoshina, K., Ishimura, S., Fuseya, T., Watanabe, Y. S., Yoshida, H., Shimamoto, K., & Miura, T. (2015) · Hypertension Research · doi:10.1038/hr.2015.2 · Cited by 52
Self-citationTanaka, M., Furuhashi, M., Okazaki, Y., Mita, T., Fuseya, T., Ohno, K., Ishimura, S., Yoshida, H., & Miura, T. (2015) · Nephron Clinical Practice · doi:10.1159/000368412 · Cited by 52
Self-citationFatty acid binding protein (FABP) inhibitors: a patent review (2012-2015)
Wang, Y., Liu, C., & Zhu, H. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2016.1182500 · Cited by 52
Yan, F., Liu, X., Zhang, S., Su, J., Zhang, Q., & Chen, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092496 · Cited by 52
MicroRNAs Regulated by Adiponectin as Novel Targets for Controlling Adipose Tissue Inflammation
Ge, Q., Gérard, J., Noël, L., Scroyen, I., & Brichard, S. M. (2012) · Endocrinology · doi:10.1210/en.2012-1623 · Cited by 52
A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting
Syamsunarno, M. R. A. A., Iso, T., Hanaoka, H., Yamaguchi, A., Obokata, M., Koitabashi, N., Goto, K., Hishiki, T., Nagahata, Y., Matsui, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079386 · Cited by 52
Furuhashi, M., Ogura, M., Matsumoto, M., Yuda, S., Muranaka, A., Kawamukai, M., Omori, A., Tanaka, M., Moniwa, N., Ohnishi, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00177-w · Cited by 55
Self-citationIndependent links between plasma xanthine oxidoreductase activity and levels of adipokines
Furuhashi, M., Matsumoto, M., Murase, T., Nakamura, T., Higashiura, Y., Koyama, M., Tanaka, M., Moniwa, N., Ohnishi, H., Saitoh, S., et al. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12982 · Cited by 49
Self-citationMetabolic and Molecular Mechanisms of Macrophage Polarisation and Adipose Tissue Insulin Resistance
Orliaguet, L., Ejlalmanesh, T., & Alzaïd, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165731 · Cited by 53
Defining Molecular Signature of Pro-Immunogenic Radiotherapy Targets in Human Prostate Cancer Cells
Aryankalayil, M. J., Makinde, A. Y., Gameiro, S. R., Hodge, J. W., Rivera-Solis, P. P., Palayoor, S. T., Ahmed, M. M., & Coleman, C. N. (2014) · Radiation Research · doi:10.1667/rr13731.1 · Cited by 49
Kishore, P., Li, W., Tonelli, J., Lee, D.-E., Koppaka, S., Zhang, K., Lin, Y., Kehlenbrink, S., Scherer, P. E., & Hawkins, M. A. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000292 · Cited by 48
Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy
Zhang, J., Qiao, C., Chang, L., Guo, Y., Fan, Y., Villacorta, L., Chen, Y. E., & Zhang, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157372 · Cited by 48
Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice
Suffee, N., Baptista, E., Piquereau, J., Ponnaiah, M., Doisne, N., Ichou, F., Lhomme, M., Pichard, C., Galand, V., Mougenot, N., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab367 · Cited by 47
Hsu, H.-C., Tong, S., Zhou, Y., Elmes, M. W., Su, Y., Kaczocha, M., Deutsch, D. G., Rizzo, R. C., Ojima, I., & Li, H. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00194 · Cited by 46
Wu, Y., Chang, T., Chang, C., & Chen, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239245 · Cited by 46
Okazaki, Y., Furuhashi, M., Tanaka, M., Mita, T., Fuseya, T., Ishimura, S., Watanabe, Y. S., Hoshina, K., Akasaka, H., Ohnishi, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115429 · Cited by 45
Self-citationSerum fatty acid binding protein 4, free fatty acids, and metabolic risk markers
Karakas, S. E., Almario, R. U., & Kim, K. (2009) · Metabolism · doi:10.1016/j.metabol.2009.02.024 · Cited by 45
Furuhashi, M., Yuda, S., Muranaka, A., Kawamukai, M., Matsumoto, M., Tanaka, M., Moniwa, N., Ohnishi, H., Saitoh, S., Shimamoto, K., et al. (2018) · Circulation Journal · doi:10.1253/circj.cj-17-1295 · Cited by 45
Self-citationLooking on the “brite” side exercise-induced browning of white adipose tissue
Townsend, L. K., & Wright, D. C. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2177-1 · Cited by 44
Li, H., Herrmann, T. R. W., Seeßle, J., Liebisch, G., Merle, U., Stremmel, W., & Chamulitrat, W. (2022) · Bioscience Reports · doi:10.1042/bsr20211854 · Cited by 43
Liang, X., Gupta, K., Quintero, J. R., Cernadas, M., Kobzik, L., Christou, H. A., Pier, G. B., Owen, C. A., & Çataltepe, S. (2018) · The FASEB Journal · doi:10.1096/fj.201802002r · Cited by 42
Hepatic Gene Networks in Morbidly Obese Patients With Nonalcoholic Fatty Liver Disease
Gawrieh, S., Baye, T. M., Carless, M. A., Wallace, J. R., KOMOROWSKI, R. A., Kleiner, D. E., Andris, D. A., Makladi, B., Cole, R., Charlton, M., et al. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0171-6 · Cited by 44
Role of hepatic peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease
Lee, S. M., Muratalla, J. T., Sierra‐Cruz, M., & Córdoba‐Chacón, J. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0155 · Cited by 43
Khalyfa, A., Bhushan, B., Hegazi, M., Kim, J., Gozal, D., Bhattacharjee, R., Capdevila, Ó. S., & Gozal, D. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-18 · Cited by 42
Kim, Y.-C., Cho, Y.-K., Lee, W., Kim, H.-J., Park, J., Park, D. I., Sohn, C.-I., Jeon, W.-K., Kim, B.-I., Park, S., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.02.007 · Cited by 42
Zhou, Z., Tao, Y., Zhao, H., & Wang, Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.666344 · Cited by 42
Fatty Acid Metabolism in Endothelial Cell
Liu, B., & Dai, Z. (2022) · Genes · doi:10.3390/genes13122301 · Cited by 41
Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice
Mori, K., Tsuchiya, K., Nakamura, S., Miyachi, Y., Shiba, K., Ogawa, Y., & Kitamura, K. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0886-1 · Cited by 43
Duan, H., Jing, L., Xiang, J., Ju, C., Wu, Z., Liu, J., Ma, X., Chen, X., Liu, Z., Feng, J., et al. (2022) · Advanced Science · doi:10.1002/advs.202103719 · Cited by 38
New insights into circulating FABP4: Interaction with cytokeratin 1 on endothelial cell membranes
Saavedra-García, P., Girona, J., Bosquet, A., Guaita, S., Canela-Canela, N., Aragonès, G., Heras, M., & Masana, L. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.09.002 · Cited by 39
Peng, X., Studholme, K. M., Kanjiya, M. P., Luk, J., Bogdan, D., Elmes, M. W., Carbonetti, G., Tong, S., Teng, Y. G., Rizzo, R. C., et al. (2017) · Molecular Pain · doi:10.1177/1744806917697007 · Cited by 40
Yamamoto, T., Furuhashi, M., Sugaya, T., Oikawa, T., Matsumoto, M., Funahashi, Y., Matsukawa, Y., Gotoh, M., & Miura, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167825 · Cited by 38
Self-citationMicroRNA regulated macrophage activation in obesity
Li, C., Qu, L., Farragher, C., Vella, A. T., & Zhou, B. (2019) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2019-0011 · Cited by 38
Saito, N., Furuhashi, M., Koyama, M., Higashiura, Y., Akasaka, H., Tanaka, M., Moniwa, N., Ohnishi, H., Saitoh, S., Ura, N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83494-5 · Cited by 37
Self-citationRole of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review
Nguyen, H. C., Qadura, M., & Singh, K. K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113390 · Cited by 36
Pereira, S. S., Teixeira, L. G., Aguilar, E. C., Matoso, R. D. O., Soares, F. L. P., Ferreira, A. V. M., & Alvarez-Leite, J. I. (2011) · Animal Science Journal · doi:10.1111/j.1740-0929.2011.00982.x · Cited by 35
Circulating FABP4 is a marker of metabolic and cardiovascular risk in SLE patients
Parra, S., Cabré, A., Marimón, F., Ferré, R., Ribalta, J., Gonzàlez, M., Heras, M., Castro, A., & Masana, L. (2014) · Lupus · doi:10.1177/0961203313517405 · Cited by 34
Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity
Barraco, G. M., Luciano, R., Semeraro, M., Prieto-Hontoria, P. L., & Manco, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151119760 · Cited by 33
Ge, Q., Rycken, L., Noël, L., Maury, E., & Brichard, S. M. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00153.2011 · Cited by 34
Furuhashi, M., Sakuma, I., Morimoto, T., Higashiura, Y., Sakai, A., Matsumoto, M., Sakuma, M., Shimabukuro, M., Nomiyama, T., Arasaki, O., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.575557 · Cited by 34
Self-citationWang, X. Q., Yang, K., He, Y. S., Lu, L., & Shen, W. F. (2011) · Lipids · doi:10.1007/s11745-011-3542-4 · Cited by 34
Hellberg, K., Grimsrud, P. A., Kruse, A. C., Banaszak, L. J., Ohlendorf, D. H., & Bernlohr, D. (2010) · Protein Science · doi:10.1002/pro.427 · Cited by 34
Adipose lineage specification of bone marrow-derived myeloid cells
Majka, S. M., Miller, H. L., Sullivan, T., Erickson, P. F., Kong, R., Weiser-Evans, M. C. M., Nemenoff, R. A., Moldovan, R., Morandi, S. A., Davis, J. A., et al. (2012) · Adipocyte · doi:10.4161/adip.21496 · Cited by 33
Tanaka, M., Takahashi, S., Higashiura, Y., Sakai, A., Koyama, M., Saitoh, S., Shimamoto, K., Ohnishi, H., & Furuhashi, M. (2021) · Journal of Diabetes Investigation · doi:10.1111/jdi.13735 · Cited by 33
Self-citationWalenna, N. F., Kurihara, Y., Chou, B., Ishii, K., Soejima, T., Itoh, R., Shimizu, A., Ichinohe, T., & Hiromatsu, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.005 · Cited by 32
Fatty acid binding protein 5 regulates lipogenesis and tumor growth in lung adenocarcinoma
Garcia, K. A., Costa, M. L., Lacunza, E., Martinez, M. E., Córsico, B., & Scaglia, N. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120621 · Cited by 32
Reactive oxygen species production is increased in the peripheral blood monocytes of obese patients
Degasperi, G. R., Denis, R., Morari, J., Solon, C., Geloneze, B., Stabe, C. F. C., Pareja, J. C., Vercesi, A. E., & Velloso, L. A. (2009) · Metabolism · doi:10.1016/j.metabol.2009.04.002 · Cited by 31
SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction
Ma, X., Ren, X., Han, P., Hu, S., Wang, J., & Yin, J. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0059-5 · Cited by 31
Adipose Tissue Macrophages: MR Tracking to Monitor Obesity-associated Inflammation
Luciani, A., Dechoux, S., Deveaux, V., Poirier‐Quinot, M., Luciani, N., Lévy, M., Ballet, S., Manin, S., Péchoux, C., Autret, G., et al. (2012) · Radiology · doi:10.1148/radiol.12111957 · Cited by 31
Charles, K. N., Li, M., Engin, F., Arruda, A. P., Inouye, K., & Hotamışlıgil, G. S. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.051 · Cited by 30
Huang, C., Wu, Y., Hsieh, A., Hung, Y., Chen, W., & Yang, W. (2013) · Critical Care · doi:10.1186/cc12498 · Cited by 30
Liu, X., Huang, X., Lin, W., Wang, D., Diao, Y., Li, H., Hui, X. H., Wang, Y., Xu, A., Wu, D., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.03.063 · Cited by 30
Huang, Y., Yong, P., Dickey, D. M., Vora, S. M., Wu, H., & Bernlohr, D. (2022) · Endocrinology · doi:10.1210/endocr/bqac014 · Cited by 29
Farabegoli, F., Santaclara, F. J., Costas-Imbernón, D., Alonso, M., Abril, A. G., Espiñeira, M., Ortea, I., & Costas, C. (2023) · Nutrients · doi:10.3390/nu15040859 · Cited by 30
Rogers, C., Moukdar, F., McGee, M. A., Davis, B. A., Buehrer, B. M., Daniel, K. W., Collins, S., Barakat, H. A., & Robidoux, J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1033 · Cited by 31
Furuhashi, M., Omori, A., Matsumoto, M., Kataoka, Y., Tanaka, M., Moniwa, N., Ohnishi, H., Yoshida, H., Saitoh, S., Shimamoto, K., et al. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.04.037 · Cited by 29
Self-citationRegulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5
Zhang, Y., Nguyen, T. D., Tang, P., Kennedy, N. J., Jiao, H., Zhang, M., Reynolds, J. M., Jaeschke, A., Martín‐Orozco, N., Chung, Y., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.660969 · Cited by 28
Anti-Inflammatory Diets for Obesity and Diabetes
Sears, B. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10718115 · Cited by 27
Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas
Prayugo, F. B., Kao, T., Anuraga, G., Ta, H. D. K., Chuang, J., Lin, L.-C., Wu, Y.-F., Wang, C., & Lee, K. (2021) · Biomedicines · doi:10.3390/biomedicines9101460 · Cited by 27
FABP4 in Paneth cells regulates antimicrobial protein expression to reprogram gut microbiota
Su, L., Jin, M., Chen, X., Gao, Y., Yang, Y., Qi, H., Zhang, Q., Yang, X., Wang, Y., Zhang, Y., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2139978 · Cited by 27
FABP4 and Cardiovascular Events in Peripheral Arterial Disease
Höbaus, C., Herz, C. T., Pesau, G., Wrba, T., Koppensteiner, R., & Schernthaner, G.-H. (2017) · Angiology · doi:10.1177/0003319717728226 · Cited by 27
Tasinov, O., Dincheva, I. N., Badjakov, I. K., Kiselova-Kaneva, Y. D., Galunska, B. T., Nogueiras, R., & Ivanova, D. G. (2021) · Plants · doi:10.3390/plants10112446 · Cited by 26
Nguyen, H. C., Bu, S., Nikfarjam, S., Rasheed, B., Michels, D., Singh, A., Singh, S., Marszal, C., McGuire, J. J., Feng, Q., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102921 · Cited by 29
Qi, L., Matsuo, K., Pereira, A., Lee, Y. T., Zhong, F., He, Y., Zushin, P. H., Gröger, M., Sharma, A., Willenbring, H., et al. (2023) · Small · doi:10.1002/smll.202203725 · Cited by 25
Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery
Shinoda, S., Nakamura, N., Roach, B., Bernlohr, D., Ikramuddin, S., & Yamamoto, M. (2022) · Biomedicines · doi:10.3390/biomedicines10061284 · Cited by 26
Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus
Zhu, L., Yang, B., Ma, D., Wang, L., & Wu, D. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s249605 · Cited by 24
Khalafi, M., Alamdari, K. A., Symonds, M. E., Rohani, H., & Sakhaei, M. H. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2064424 · Cited by 26
Zhang, R., Miao, J., Song, Y., Zhang, W., Xu, L., Chen, Y., Zhang, L., Gao, H., Zhu, B., Li, J., et al. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00112.2018 · Cited by 24
Furuhashi, M., Matsumoto, M., Hiramitsu, S., Omori, A., Tanaka, M., Moniwa, N., Yoshida, H., Ishii, J., & Miura, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154482 · Cited by 23
Self-citationMacrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice
Saito, N., Kimura, S., Miyamoto, T., Fukushima, S., Amagasa, M., Shimamoto, Y., Nishioka, C., Okamoto, S., Toda, C., Washio, K., et al. (2017) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2017.01.009 · Cited by 25
Niu, G., Li, J., Wang, H., Ren, Y., & Bai, J. (2016) · BioMed Research International · doi:10.1155/2016/9382092 · Cited by 23
Fa(c)t checking: How fatty acids shape metabolism and function of macrophages and dendritic cells
Almeida, L., & Everts, B. (2021) · European Journal of Immunology · doi:10.1002/eji.202048944 · Cited by 24
The Role of Individually Selected Diets in Obese Women with PCOS—A Review
Chudzicka-Strugała, I., Gołębiewska, I., Banaszewska, B., Brudecki, G. P., & Zwoździak, B. (2022) · Nutrients · doi:10.3390/nu14214555 · Cited by 25
Message Transmission Between Adipocyte and Macrophage in Obesity
Engin, A. B. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_9 · Cited by 22
Lamounier‐Zepter, V., Look, C., Schunck, W., Schlottmann, I., Woischwill, C., Bornstein, S. R., Xu, A., & Morano, I. L. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.193 · Cited by 22
Walenna, N. F., Kurihara, Y., Chou, B., Ishii, K., Soejima, T., & Hiromatsu, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010683 · Cited by 20
Zhang, J., Wang, Y., Gao, Z., Yun, Z., & Ye, J. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05656.x · Cited by 20
Hayashi, Y., Kajimoto, K., Iida, S., Sato, Y. Z., Mizufune, S., Kaji, N., Kamiya, H., Baba, Y., & Harashima, H. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.1033 · Cited by 20
Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients
Bove, R. M., Healy, B. C., Musallam, A., Soltany, P., Diaz‐Cruz, C., Sattarnezhad, N., Glanz, B. I., Kivisäkk, P., Miller, K. K., & Chitnis, T. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458517750768 · Cited by 20
Wang, S. F., Matthan, N. R., Wu, D., Reed, D. B., Bapat, P., Yin, X., Grammas, P., Shen, C., & Lichtenstein, A. H. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.04.009 · Cited by 20
Pan, J. A., Michaëlsson, E., Shaw, P. W., Kuruvilla, S., Kramer, C. M., Gan, L., Keeley, E. C., & Salerno, M. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001875 · Cited by 20
Quinn, G. Z., Dhillon, P., & Suszták, K. (2020) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2020.01.010 · Cited by 19
Palmitic acid and palmitoylation in cancer: Understanding, insights, and challenges
Song, P., Jiang, Q., Wu, X., Bu, L., Xie, W., Wei, W., Xing, X., & Guo, J. (2025) · The Innovation · doi:10.1016/j.xinn.2025.100918 · Cited by 20
Metadata
- Authors
- Furuhashi, M., Fucho, R., Görgün, C. Z., Tuncman, G., Cao, H., & Hotamisligil, G. S.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2008-06-01
- Volume
- 118
- Issue
- 7
- Pages
- 2640-50
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2423863
- OpenAlex
- W2025059877
- Semantic Scholar
- 006094a9303b57c51c4cf09b8015eafb6569c638
- Cited by
- 332
- References
- 34
- Citations by year
- 2025: 12 · 2024: 18 · 2023: 14 · 2022: 23 · 2021: 15 · 2020: 17 · 2019: 19 · 2018: 15 · 2017: 18 · 2016: 23 · 2015: 17 · 2014: 18 · 2013: 29 · 2012: 19
- FWCI
- 18.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Iacocca Family Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL065405, HL 65405)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK52540, R90DK071507, P30DK040561, DK71507-04)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- fatty acid binding protein, FABP4, FABP5, adipose tissue inflammation, obesity, macrophages, adipocytes, insulin signaling, glucose uptake, inflammatory cytokines, bone marrow chimerism, metabolic homeostasis
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Cell Communication, Glucose, Inflammation, Insulin, Liver, Macrophages, Male, Mice, Inbred C57BL, Mice, Transgenic, Neoplasm Proteins, Obesity, Receptor, Insulin, Tumor Necrosis Factor-alpha, Bone Marrow Transplantation, Adipocytes, Mice, Knockout, Chemokine CCL2, Fatty Acid-Binding Proteins, Proto-Oncogene Proteins c-akt, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
