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Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.
Open accessAbstract
IL-12 is essential for T helper 1 (Th1) development and inhibits the induction of Th2 responses. Atopic diseases, which are characterized by Th2 responses, are associated with the overproduction of histamine. Here we present evidence that histamine, at physiological concentrations, strongly inhibits human IL-12 p40 and p70 mRNA and protein production by human monocytes. The use of specific histamine receptor antagonists reveals that this inhibition is mediated via the H2 receptor and induction of intracellular cAMP. The inhibition of IL-12 production is independent of IL-10 and IFN-gamma. The observation that histamine strongly reduces the production of the Th1-inducing cytokine IL-12 implies a positive feedback mechanism for the development of Th2 responses in atopic patients.
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Citations
Cited by
T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal
Kaliński, P., Hilkens, C. M. U., Wierenga, E. A., & Kapsenberg, M. L. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01547-9 · Cited by 933
Corral, L. G., Haslett, P. A. J., Muller, G. W., Chen, R., Wong, L.-M., Ocampo, C. J., Patterson, R. T., Stirling, D. I., & Kaplan, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.380 · Cited by 656
Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction
Vieira, P. L., de Jong, E. C., Wierenga, E. A., Kapsenberg, M. L., & Kaliński, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4507 · Cited by 502
Dendritic Cells: Immune Regulators in Health and Disease
Lipscomb, M. F., & Masten, B. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00023.2001 · Cited by 465
In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure
Meiler, F., Zumkehr, J., Klunker, S., Rückert, B., Akdis, C. A., & Akdis, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080193 · Cited by 411
Metadata
- Authors
- van der Pouw Kraan, T. C., Snijders, A., Boeije, L. C., de Groot, E. R., Alewijnse, A. E., Leurs, R., & Aarden, L. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-11-15
- Volume
- 102
- Issue
- 10
- Pages
- 1866-1873
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2137083667
- Cited by
- 207
- References
- 0
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van der Pouw Kraan, T. C., Snijders, A., Boeije, L. C., de Groot, E. R., Alewijnse, A. E., Leurs, R., & Aarden, L. A. (1998). Histamine inhibits the production of interleukin-12 through interaction with H2 receptors. Journal of Clinical Investigation. https://doi.org/10.1172/jci3692
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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