The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction
Open accessAbstract
Dendritic cells (DC) are key initiators of primary immune responses. Myeloid DC can secrete IL-12, a potent Th1-driving factor, and are often viewed as Th1-promoting APC. Here we show that neither a Th1- nor a Th2-inducing function is an intrinsic attribute of human myeloid DC, but both depend on environmental instruction. Uncommitted immature DC require exposure to IFN-γ, at the moment of induction of their maturation or shortly thereafter, to develop the capacity to produce high levels of IL-12p70 upon subsequent contact with naive Th cells. This effect is specific for IFN-γ and is not shared by other IL-12-inducing factors. Type 1-polarized effector DC, matured in the presence of IFN-γ, induce Th1 responses, in contrast to type 2-polarized DC matured in the presence of PGE2 that induce Th2 responses. Type 1-polarized effector DC are resistant to further modulation, which may facilitate their potential use in immunotherapy.
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Cites
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Cited by
Dendritic-cell control of pathogen-driven T-cell polarization
Kapsenberg, M. L. (2003) · Nature Reviews Immunology · doi:10.1038/nri1246 · Cited by 1,437
Self-citationDendritic cell regulation of TH1-TH2 development
Moser, M., & Murphy, K. M. (2000) · Nature Immunology · doi:10.1038/79734 · Cited by 1,118
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Close encounters of different kinds: Dendritic cells and NK cells take centre stage
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Metadata
- Authors
- Vieira, P. L., de Jong, E. C., Wierenga, E. A., Kapsenberg, M. L., & Kaliński, P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-05-01
- Volume
- 164
- Issue
- 9
- Pages
- 4507-4512
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1579010799
- Cited by
- 502
- References
- 31
- FWCI
- 15.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vieira, P. L., de Jong, E. C., Wierenga, E. A., Kapsenberg, M. L., & Kaliński, P. (2000). Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction. The Journal of Immunology. https://doi.org/10.4049/jimmunol.164.9.4507
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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