The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo.
Open accessAbstract
Perlecan, a ubiquitous heparan sulfate proteoglycan, possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). In this report we blocked perlecan expression by using either constitutive CMV-driven or doxycycline- inducible antisense constructs. Growth of colon carcinoma cells was markedly attenuated upon obliteration of perlecan gene expression and these effects correlated with reduced responsiveness to and affinity for mitogenic keratinocyte growth factor (FGF-7). Exogenous perlecan effectively reconstituted the activity of FGF-7 in the perlecan-deficient cells. Moreover, soluble FGF-7 specifically bound immobilized perlecan in a heparan sulfate-independent manner. In both tumor xenografts induced by human colon carcinoma cells and tumor allografts induced by highly invasive mouse melanoma cells, perlecan suppression caused substantial inhibition of tumor growth and neovascularization. Thus, perlecan is a potent inducer of tumor growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve cancer treatment.
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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
Cited by
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904
Nugent, M. A., & Iozzo, R. V. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00123-5 · Cited by 547
Self-citationTheocharis, A. D., Skandalis, S. S., Tzanakakis, G. N., & Karamanos, N. K. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07800.x · Cited by 403
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics
Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A., Vigetti, D., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00354 · Cited by 367
Self-citationStill More Complexity in Mammalian Basement Membranes
Erickson, A. C., & Couchman, J. R. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004801001 · Cited by 303
Metadata
- Authors
- Sharma, B., Handler, M., Eichstetter, I., Whitelock, J. M., Nugent, M. A., & Iozzo, R. V.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-10-15
- Volume
- 102
- Issue
- 8
- Pages
- 1599-1608
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2071178504
- Cited by
- 194
- References
- 2
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sharma, B., Handler, M., Eichstetter, I., Whitelock, J. M., Nugent, M. A., & Iozzo, R. V. (1998). Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. Journal of Clinical Investigation. https://doi.org/10.1172/jci3793
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