The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Cellular Mechanisms of Aortic Aneurysm Formation
Open accessAbstract
Aortic aneurysms are a common vascular disease in Western populations that can involve virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than thoracic aortic aneurysms and combined they account for >25 000 deaths in the United States annually. Although thoracic and abdominal aortic aneurysms share some common characteristics, including the gross anatomic appearance, alterations in extracellular matrix, and loss of smooth muscle cells, they are distinct diseases. In recent years, advances in genetic analysis, robust molecular tools, and increased availability of animal models have greatly enhanced our knowledge of the pathophysiology of aortic aneurysms. This review examines the various proposed cellular mechanisms responsible for aortic aneurysm formation and identifies opportunities for future studies.
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Cites
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Cellular mechanisms and physiological consequences of redox-dependent signalling
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Reactive Oxygen Species in Metabolic and Inflammatory Signaling
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Cited by
Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
Jana, S., Hu, M., Shen, M., & Kassiri, Z. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0286-3 · Cited by 226
Hu, K., Zhong, L., Lin, W., Zhao, G., Pu, W., Feng, Z., Zhou, M., Ding, J., & Zhang, J. (2024) · ACS Nano · doi:10.1021/acsnano.4c00120 · Cited by 39
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“In an inflammatory milieu, MMPs contribute to the degradation of collagen and elastic fibres in the intima and adventitia of the abdominal aorta, resulting in weakened arterial wall elasticity and compromised integrity [23, 24].”
BackgroundToczek, J., Gona, K., Liu, Y., Ahmad, A., Ghim, M., Ojha, D., Kukreja, G., Salarian, M., Luehmann, H., Heo, G. S., et al. (2023) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.122.014615 · Cited by 12
Metadata
- Authors
- Quintana, R. A., & Taylor, W. R.
- Venue
- Circulation Research
- Published
- 2019-02-15
- Volume
- 124
- Issue
- 4
- Pages
- 607-618
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2912711077
- Cited by
- 435
- References
- 135
- FWCI
- 28.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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