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Cited by 396

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

Open access
Looney, Mark R., Nguyen, John X., Hu, Yongmei, Van Ziffle, Jessica A., Lowell, Clifford A., Matthay, Michael A.·2009·Journal of Clinical Investigation
DOI 10.1172/jci38432
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Abstract

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged with MHC class I mAb. In this study, when mice housed in a rodent, specific pathogen-free barrier room were challenged with MHC I mAb, there was significant protection from TRALI compared with nonbarrier mice. Priming mice with LPS restored lung injury with mAb challenge. Using TLR4-deficient bone marrow chimeras, the priming phenotype was restricted to animals with WT hematopoietic cells, and depletion of either neutrophils or platelets was protective. Both neutrophils and platelets were sequestered in the lungs of mice with TRALI, and retention of platelets was neutrophil dependent. Interestingly, treatment with aspirin prevented lung injury and mortality, but blocking the P selectin or CD11b/CD18 pathways did not. These data suggest a 2-step mechanism of TRALI: priming of hematopoietic cells, followed by vascular deposition of activated neutrophils and platelets that then mediate the severe lung injury. Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach.

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Metadata

Authors
Looney, M. R., Nguyen, J. X., Hu, Y., Van Ziffle, J. A., Lowell, C. A., & Matthay, M. A.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2009-10-05
Volume
119
Issue
11
Pages
3450-61
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci38432
OpenAlex
W2092616294
Cited by
396
References
44
FWCI
16.26
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. https://app.cochat.ai/papers/10.1172/jci38432
The paper
Looney, M. R., Nguyen, J. X., Hu, Y., Van Ziffle, J. A., Lowell, C. A., & Matthay, M. A. (2009). Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. Journal of Clinical Investigation. https://doi.org/10.1172/jci38432

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.