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Cited by 724

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Transfusion-related acute lung injury: Definition and review

Toy, Pearl, Popovsky, Mark A., Abraham, Edward, Ambruso, Daniel R., Holness, Leslie G., Kopko, Patricia M., McFarland, Janice G., Nathens, Avery B., Silliman, Christopher C., Stroncek, David·2005·Critical Care Medicine

Abstract

BACKGROUND: Transfusion-related acute lung injury (TRALI) is now the leading cause of transfusion-associated mortality, even though it is probably still underdiagnosed and underreported. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE ACTION: The National Heart, Lung, and Blood Institute convened a working group to identify areas of research needed in TRALI. The working group identified the immediate need for a common definition and thus developed the clinical definition in this report. MAJOR CONCEPTS IN THE DEFINITION: The major concept is that TRALI is defined as new acute lung injury occurring during or within 6 hrs after a transfusion, with a clear temporal relationship to the transfusion. Also, another important concept is that acute lung injury temporally associated with multiple transfusions can be TRALI, because each unit of blood or blood component can carry one or more of the possible causative agents: antileukocyte antibody, biologically active substances, and other yet unidentified agents. RECOMMENDATION: Using the definition in this report, clinicians can diagnose and report TRALI cases to the blood bank; importantly, researchers can use this definition to determine incidence, pathophysiology, and strategies to prevent this leading cause of transfusion-associated mortality.

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Crossref · 10.1097/01.ccm.0000159849.94750.51

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Metadata

Authors
Toy, P., Popovsky, M. A., Abraham, E., Ambruso, D. R., Holness, L. G., Kopko, P. M., McFarland, J. G., Nathens, A. B., Silliman, C. C., & Stroncek, D.
Venue
Critical Care Medicine
Published
2005-04
Volume
33
Issue
4
Pages
721-726
ISSN
0090-3493 (ISSN-L)
OpenAlex
W2071688599
Cited by
724
References
2
FWCI
26.41
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Transfusion-related acute lung injury: Definition and review. https://app.cochat.ai/papers/10.1097/01.ccm.0000159849.94750.51
The paper
Toy, P., Popovsky, M. A., Abraham, E., Ambruso, D. R., Holness, L. G., Kopko, P. M., McFarland, J. G., Nathens, A. B., Silliman, C. C., & Stroncek, D. (2005). Transfusion-related acute lung injury: Definition and review. Critical Care Medicine. https://doi.org/10.1097/01.ccm.0000159849.94750.51

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.