The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
Open accessAbstract
The molecular signaling events by which leptin exerts its functions in vivo are not well delineated. Here, we show a novel leptin signaling mechanism that requires phosphoinositide 3-kinase (PI 3-kinase)-dependent activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and subsequent suppression of cAMP levels. In pancreatic beta cells, leptin causes the activation of PDE3B, which leads to marked inhibition of glucagon-like peptide-1-stimulated insulin secretion. The effect of leptin is abolished when insulin secretion is induced with cAMP analogues that cannot be hydrolyzed by PDE3B. Selective inhibitors of PDE3B and PI 3-kinase completely prevent the leptin effect on insulin secretion and cAMP accumulation. The results demonstrate that one of the physiological effects of leptin, suppression of insulin secretion, is mediated through activation of PDE3B and suggest PDE3B as a mediator of leptin action in other tissues.
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Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
Bjørbæk, C., Uotani, S., da Silva, B., & Flier, J. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32686 · Cited by 890
Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action
Rossetti, L., Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., & Wang, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27758 · Cited by 304
Cited by
Lugnier, C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.07.003 · Cited by 870
Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes
Fu, Z., R. Gilbert, E., & Liu, D. (2013) · Current Diabetes Reviews · doi:10.2174/157339913804143225 · Cited by 732
Mechanisms of insulin resistance in obesity
Ye, J. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0262-6 · Cited by 699
Intracellular signalling pathways activated by leptin
Frühbeck, G. (2006) · Biochemical Journal · doi:10.1042/bj20051578 · Cited by 696
Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus
Kohno, D., Gao, H.-Z., Muroya, S., Kikuyama, S., & Yada, T. (2003) · Diabetes · doi:10.2337/diabetes.52.4.948 · Cited by 386
Metadata
- Authors
- Zhao, A. Z., Bornfeldt, K. E., & Beavo, J. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-09-01
- Volume
- 102
- Issue
- 5
- Pages
- 869-873
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1983372510
- Cited by
- 236
- References
- 3
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhao, A. Z., Bornfeldt, K. E., & Beavo, J. A. (1998). Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. Journal of Clinical Investigation. https://doi.org/10.1172/jci3920
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