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Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
Open accessAbstract
Hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha display unique and sometimes opposing activities in regulating cellular energy homeostasis, cell fate decisions, and oncogenesis. Macrophages exposed to hypoxia accumulate both HIF-1alpha and HIF-2alpha, and overexpression of HIF-2alpha in tumor-associated macrophages (TAMs) is specifically correlated with high-grade human tumors and poor prognosis. However, the precise role of HIF-2alpha during macrophage-mediated inflammatory responses remains unclear. To fully characterize cellular hypoxic adaptations, distinct functions of HIF-1alpha versus HIF-2alpha must be elucidated. We demonstrate here that mice lacking HIF-2alpha in myeloid cells (Hif2aDelta/Delta mice) are resistant to lipopolysaccharide-induced endotoxemia and display a marked inability to mount inflammatory responses to cutaneous and peritoneal irritants. Furthermore, HIF-2alpha directly regulated proinflammatory cytokine/chemokine expression in macrophages activated in vitro. Hif2aDelta/Delta mice displayed reduced TAM infiltration in independent murine hepatocellular and colitis-associated colon carcinoma models, and this was associated with reduced tumor cell proliferation and progression. Notably, HIF-2alpha modulated macrophage migration by regulating the expression of the cytokine receptor M-CSFR and the chemokine receptor CXCR4, without altering intracellular ATP levels. Collectively, our data identify HIF-2alpha as an important regulator of innate immunity, suggesting it may be a useful therapeutic target for treating inflammatory disorders and cancer.
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“Myeloid-specific HIF-1α deletion results in defective glycolysis and ATP generation, leading to impairment of myeloid cell motility and function (Fig. 2B) [61,62].”
From Revisiting the HIF switch in the tumor and its immune microenvironment. (2022) · cites this paper as [62]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both HIF-1α or HIF-2α expression in TAMs have been associated with tumor progression and/or poor prognosis in multiple tumor types, whereas lack of HIF-1α or HIF-2α in TAMs decreases metastasis, cell proliferation, and expression of pro-inflammatory cytokines such as IL-6 [73–76].”
From The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation (2025) · cites this paper as [76]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both HIF-1α or HIF-2α expression in TAMs have been associated with tumor progression and/or poor prognosis in multiple tumor types, whereas lack of HIF-1α or HIF-2α in TAMs decreases metastasis, cell proliferation, and expression of pro-inflammatory cytokines such as IL-6 [73–76].”
From The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation (2025) · cites this paper as [76]
Experimental — accuracy not yet measuredIn the citing paper
“Indeed, TAM presence and number has been directly correlated with prognosis in a number of cancer types and model systems [42–44].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [42]
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“HIF2α is required for cytokine induction in macrophages (Imtiyaz et al., 2010).”
From Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection (2015) · cites this paper as Imtiyaz et al., 2010
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“Hif-2α is an important transcriptional regulator of hypoxic responses, controlling a variety of processes including hypoxic regulation of EPO synthesis [48, 49] and macrophage function [50, 51].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [51]
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Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251
Activators and Target Genes of Rel/NF-кB Transcription Factors
Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179
Lutz, M. B., Kukutsch, N. A., Ogilvie, A. L. J., Rößner, S., Koch, F., Romani, N., & Schuler, G. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00204-x · Cited by 2,972
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
Research works printed but not linked: 2
- Raick, 1973, Cancer Res., 33, 269
- Leek, 2002, Cancer Res., 62, 1326
Cited by
Sorted by citations
Items 301–400 of 461
Vanderborght, B., Muynck, K. D., Lefere, S., Geerts, A. M., Degroote, H., Verhelst, X., Vlierberghe, H. V., & Devisscher, L. (2020) · Oncotarget · doi:10.18632/oncotarget.27830 · Cited by 17
Yu, T., Wen, M., Li, C., Cheng, C.-H., Wu, M.-J., Chen, C., & Shu, K. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs377 · Cited by 17
Korovina, I., Neuwirth, A., Sprott, D., Weber, S., Pasha, S. P. B. S., Gercken, B., Breier, G., El‐Armouche, A., Deußen, A., Karl, M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800430r · Cited by 17
Lee‐Rueckert, M., Jauhiainen, M., Kovanen, P. T., & Escolá‐Gil, J. C. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.008 · Cited by 16
Role of oxygen sensing and hypoxia-inducible factors in orchestrating innate immune responses
Low, J. T., Kim, Y., Matsushita, M., & Ho, P. (2025) · Nature Immunology · doi:10.1038/s41590-025-02317-1 · Cited by 18
Winning, S., & Fandrey, J. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0004 · Cited by 16
IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1α translation
Dehne, N., Tausendschön, M., Essler, S., Geis, T., Schmid, T., & Brüne, B. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0113045 · Cited by 18
Phagocyte–myocyte interactions and consequences during hypoxic wound healing
Zhang, S., Dehn, S., DeBerge, M., Rhee, K., Hudson, B. I., & Thorp, E. B. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.04.006 · Cited by 16
Schweickert, P. G., Piovesan, D., Mitchell, C. G., Zepeda‐Carranza, B., Zhu, W. S., Espinoza, A. Y. L., Rocha, L., Singh, J., Malgapo, M. I. P., Meleza, C., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70075 · Cited by 17
Resolving the HIF paradox in pancreatic cancer
Fuentes, N. R., Phan, J. L., Huang, Y., Lin, D., & Taniguchi, C. M. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.05.033 · Cited by 16
Macrophages play a role in inflammatory transformation of colorectal cancer
Lu, L., Liu, Y.-J., Cheng, P., Hu, D., Xu, H.-C., & Ji, G. (2021) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v13.i12.2013 · Cited by 16
Kuroishi, T., Bando, K., Endo, Y., & Sugawara, S. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft142 · Cited by 15
Eosinophils, Hypoxia-Inducible Factors, and Barrier Dysfunction in Functional Dyspepsia
Hari, S., Burns, G. L., Hoedt, E. C., Keely, S., & Talley, N. J. (2022) · Frontiers in Allergy · doi:10.3389/falgy.2022.851482 · Cited by 15
Macrophage Metabolic Signaling during Ischemic Injury and Cardiac Repair
Thorp, E. B. (2021) · Immunometabolism · doi:10.20900/immunometab20210018 · Cited by 15
Hypoxia and Hypoxia-Inducible Factors in Lymphedema
Jiang, X., Tian, W., Kim, D., McQuiston, A. S., Vinh, R., Rockson, S. G., Semenza, G. L., & Nicolls, M. R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.851057 · Cited by 16
Are Macrophages in Tumors Good Targets for Novel Therapeutic Approaches?
Alahari, S. V., Dong, S., & Alahari, S. K. (2014) · Molecules and Cells · doi:10.14348/molcells.2015.2298 · Cited by 15
The Metabolic Control of Myeloid Cells in the Tumor Microenvironment
Ramel, E., Lillo, S., Daher, B., Fioleau, M., Daubon, T., & Saleh, M. (2021) · Cells · doi:10.3390/cells10112960 · Cited by 15
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Mooli, R. G. R., Mukhi, D., Watt, M., Nagati, V., Reed, S. M., Gandhi, N. K., Oertel, M., & Ramakrishnan, S. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313114 · Cited by 14
IL-5 enhances human mast cell survival and interferon responses to viral infection
Barra, J., Liwski, C. R., Phonchareon, P., Portales‐Cervantes, L., Gaston, D., Karakach, T. K., Haidl, I. D., & Marshall, J. S. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.02.025 · Cited by 13
Steinberger, K. J., Forget, M. A., Bobko, A. A., Mihalik, N. E., Gencheva, M., Roda, J. M., Cole, S. L., Mo, X. M., Hoblitzell, E. H., Evans, R., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000185 · Cited by 15
Franchini, S., Marcianò, T., Sorlini, C., Campochiaro, C., Tresoldi, M., Sabbadini, M. G., & Dagna, L. (2015) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2015.08.047 · Cited by 13
Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer
Mukaida, N., Sasakki, S.-I., & Popivanova, B. K. (2011) · Cancers · doi:10.3390/cancers3032811 · Cited by 13
Macrophage Origin, Metabolic Reprogramming and IL-1β Signaling: Promises and Pitfalls in Lung Cancer
Guilbaud, E., Gautier, E. L., & Yvan‐Charvet, L. (2019) · Cancers · doi:10.3390/cancers11030298 · Cited by 14
Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model
Henke, N., Ferreirós, N., Geißlinger, G., Ding, M. G., Essler, S., Fuhrmann, D. C., Geis, T., Namgaladze, D., Dehne, N., & Brüne, B. (2016) · Oncotarget · doi:10.18632/oncotarget.8297 · Cited by 13
Navigating immune cell immunometabolism after liver transplantation
Zhang, W., Liu, Z., & Xu, X. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103227 · Cited by 12
Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment
Ma, J., Moussawi, K. A., Lou, H., Chan, H. F., Wang, Y., Chadwick, J., Phetsouphanh, C., Slee, E. A., Zhong, S., Leissing, T. M., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309957121 · Cited by 11
DeBerge, M., Schroth, S. L., Du, F., Yeap, X. Y., Wang, J.-J., Zhang, Z. J., Ansari, M. J., Scott, E. A., & Thorp, E. B. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2319623121 · Cited by 12
Huang, R., Liu, Z., Tian, T., Song, D., Yan, P., Yin, H., Hu, P., Zhu, X., Liu, Y., Li, Z., et al. (2020) · Bioscience Reports · doi:10.1042/bsr20200049 · Cited by 12
Steinberger, K. J., & Eubank, T. D. (2023) · Oxygen · doi:10.3390/oxygen3010005 · Cited by 15
Hu, X., Miao, P., Yu, R., & Zheng, H. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0232-x · Cited by 12
The impact of hypoxia on oncolytic virotherapy
Guo, Z. S. (2011) · Virus Adaptation and Treatment · doi:10.2147/vaat.s17832 · Cited by 12
Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity
Friedrich, D., Fecher, R. A., Rupp, J., & Deepe, G. S. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.10.008 · Cited by 12
The Role of Inflammatory Cells in Angiogenesis in Multiple Myeloma
Ribatti, D., & Vacca, A. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-0348-0837-8_14 · Cited by 12
Deng, Y., Yi, X., Gong, Y., Zhou, L., Xie, D., Wang, J., Liu, Z., Zhang, Y., & Wu, W. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119385 · Cited by 11
Wang, Y., Chen, X., Tang, N., Guo, M., & Ai, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074134 · Cited by 11
The role of iron in immunity and inflammation: implications for the response to infection
Kuvibidila, S. R., Baliga, S. B., Chandra, L. C., & French, C. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.2.193 · Cited by 11
HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
Bettadapura, M., Roys, H., Bowlin, A. K., Venugopal, G., Washam, C. L., Fry, L., Murdock, S. J., Wanjala, H., Byrum, S. D., & Weinkopff, T. (2021) · Pathogens · doi:10.3390/pathogens10121584 · Cited by 11
HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis
Huang, R., Hayashi, Y., Yan, X., Bu, J., Wang, J., Zhang, Y., Zhou, Y., Tang, Y., Wu, L., Xu, Z., et al. (2017) · Haematologica · doi:10.3324/haematol.2017.174979 · Cited by 11
Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer MicroenvironmentPreprint
Huang, Y., García, C. J. G., Lin, D., Nguyen, N. D., Fujimoto, T. N., Zhao, J., Lee, J. J., Bernard, V., Yu, M., Delahoussaye, A. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.21.445190 · Cited by 11
The role of hypoxic microenvironment in rheumatoid arthritis
Zheng, Q.-H., Zhai, Y., Wang, Y.-H., & Pan, Z. J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1633406 · Cited by 11
Acute and chronic phagocyte determinants of cardiac allograft vasculopathy
Glinton, K. E., DeBerge, M., Yeap, X., Zhang, J., Forbess, J. M., Luo, X., & Thorp, E. B. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0699-4 · Cited by 10
Hypoxia and Multilineage Communication in 3D Organoids for Human Disease Modeling
Ehab, S., Gaser, O. A., & Dayem, A. A. (2025) · Biomimetics · doi:10.3390/biomimetics10090624 · Cited by 13
Angiogenesis in Rheumatoid Arthritis
Konisti, S., Kiriakidis, S., & Paleolog, E. M. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1428-5_16 · Cited by 9
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Torres-Soria, A. K., Romero, Y., Balderas-Martínez, Y. I., Velázquez‐Cruz, R., Espíndola, L. M. T., Camarena, Á., Flores‐Soto, E., Solís‐Chagoyán, H., Ruiz, V., Carlos‐Reyes, Á., et al. (2022) · Cells · doi:10.3390/cells11192938 · Cited by 11
Hoch, M., Rauthe, J., Cesnulevicius, K., Schultz, M., Lescheid, D., Wolkenhauer, O., Chiurchiù, V., & Gupta, S. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054342 · Cited by 9
Glycation promotes pulp calcification in Type 2 diabetes rat model
Takashima, A., Miura, J., Sugiyama, K., Shimizu, M., Okada, M., Otani, T., Nagashima, T., Tsuda, T., & Araki, T. (2023) · Oral Diseases · doi:10.1111/odi.14529 · Cited by 9
Disruption of hypoxia-inducible factor-2α in neutrophils decreases colitis-associated colon cancer
Singhal, R., Kotla, N. K., Solanki, S. A., Huang, W., Bell, H. N., El-Derany, M. O., Castillo, C., & Shah, Y. M. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00182.2023 · Cited by 10
Therapeutic targeting of hypoxia inducible factor in acute respiratory distress syndrome
Tran, T., Eltzschig, H. K., & Yuan, X. (2023) · The Journal of Physiology · doi:10.1113/jp284599 · Cited by 10
Ameliorating effects of the HIF-2α inhibitor PT2385 on high-altitude polycythemia
Li, K., Luobu, G., Wu, P., Dawa, C., Xiao, X. H., Li, K., & Li, Q. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106857 · Cited by 9
Ullah, K., Ai, L., Li, Y., Liu, L., Zhang, Q., Pan, K., Humayun, Z., Piao, L. H., Sitikov, A. S., Zhao, Q., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07753-1 · Cited by 11
Pathogenesis of Reinke's Edema of the Vocal Fold
Sato, K., Kurita, T., Satô, F., Sato, K., Chitose, S., Ono, T., & Umeno, H. (2023) · The Laryngoscope · doi:10.1002/lary.31084 · Cited by 9
Greenwood, K. K., Proper, S. P., Saini, Y., Bramble, L. A., Jackson‐Humbles, D. N., Wagner, J. G., Harkema, J. R., & LaPres, J. J. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00193.2011 · Cited by 9
Endler, A., Chen, L., Li, Q., Uchida, K., Hashimoto, T., Lü, L., Xu, G., & Shibasaki, F. (2013) · Cytokine · doi:10.1016/j.cyto.2013.01.021 · Cited by 10
Scott, C., Stokes, R., Cha, K. M., Clouston, A. D., Eslam, M., Metwally, M., Swarbrick, M. M., George, J., & Gunton, J. E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225332 · Cited by 9
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Qin, J., Wu, Z., Ma, S., Wu, Y., Chen, Y., Qian, C., Lin, H., Tan, G., Liu, Q., Zhao, J., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c07064 · Cited by 8
Xu, W., Shen, Y., Wan, Z., & Guo, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1721071 · Cited by 10
Hypoxia signalling in the regulation of innate immune training
Eades, L., Drozd, M., & Cubbon, R. M. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210857 · Cited by 9
Mishra, A. K., Singh, S., Dayanandan, S., Banerjee, S., Chakraborty, S., Gopal, A. B., Samal, S., Poirah, I., Chakraborty, D., & Bhattacharyya, A. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155917 · Cited by 8
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Gardner, P. J., Liyanage, S. E., Cristante, E., Sampson, R. D., Dick, A. D., Ali, R. R., & Bainbridge, J. W. (2017) · Scientific Reports · doi:10.1038/srep40830 · Cited by 8
Keränen, M. A. I., Raissadati, A., Nykänen, A. I., Dashkevich, A., Tuuminen, R., Krebs, R., Johnson, R. S., Syrjälä, S. O., & Lemström, K. (2018) · Transplant International · doi:10.1111/tri.13310 · Cited by 8
Supriya, R., Singh, K. P., Gao, Y., Tao, D., Cheour, S., Dutheil, F., & Baker, J. S. (2022) · Biology · doi:10.3390/biology12010006 · Cited by 8
Molecular oxygen sensing: implications for visceral surgery
Kiss, J., Kirchberg, J., & Schneider, M. (2012) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-012-0930-z · Cited by 8
Huang, L., Liu, C., Deng, Y., Liu, Y., Zhao, J., Huang, X., Tang, W., Sun, Y., Qin, X. Y., & Li, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158241 · Cited by 8
Cellular mechanisms involved in the pathogenesis of airway remodeling in chronic lung disease
Arellano‐Orden, E., Acuña, C. C., Sánchez‐López, V., Ramírez, C. L., Otero, R., Marín-Hinojosa, C., & López-Campos, J. L. (2022) · European Clinical Respiratory Journal · doi:10.1080/20018525.2022.2097377 · Cited by 8
Piccolo, E. B., Ge, Z., Filipp, M. E., Sullivan, D. P., Thorp, E. B., & Sumagin, R. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00392.2024 · Cited by 8
Tumor-Associated Macrophage in Breast Tumor Microenvironment
Ma, L., Jin, Y., Xu, J., & Zhang, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26135973 · Cited by 7
Roles of hypoxia inducible factors in viral infection: Are they a potential therapeutic target?
Jia, S., Pan, S., Gao, Z., Qiao, H., Zhao, Y. M., Chuai, X., & Li, J. (2025) · Virulence · doi:10.1080/21505594.2025.2546680 · Cited by 7
The role of hypoxia-inducible factors in leukemias
Szymczak, D., Dybko, J., & Kuliczkowski, K. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/69261 · Cited by 7
Hancková, M., Miháliková, L., Pastoreková, S., & Betáková, T. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156138 · Cited by 7
Mashiko, T., Carreras, J., Ogasawara, T., Masuoka, Y., Ei, S., Takahashi, S., Nomura, T., Mori, M., Koyanagi, K., Yamamoto, S., et al. (2024) · Surgery · doi:10.1016/j.surg.2024.03.024 · Cited by 7
Respiratory epithelial cell lines exposed to anoxia produced inflammatory mediator
Shahriary, C. M., Chin, T. W., & Nussbaum, E. (2012) · Anatomy & Cell Biology · doi:10.5115/acb.2012.45.4.221 · Cited by 7
The effects of chronic smoking on lung tissue and the role of alpha lipoic acid
Öztürk, Ö., Saygın, M., Özmen, Ö., & İlhan, İ. (2018) · Biotechnic & Histochemistry · doi:10.1080/10520295.2018.1479885 · Cited by 7
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Wang, J., Alhaskawi, A., Dong, Y., Tian, T., Abdalbary, S. A., & Lü, H. (2024) · Tumori Journal · doi:10.1177/03008916241271458 · Cited by 6
Burchett, A. A., Chen, H., Najera, J., Howard, S. S., & Datta, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626024 · Cited by 6
Lu, Q., Kuang, Y., Diao, J., Zheng, J., Zhao, N., Du, C., & Wang, Y. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.01.001 · Cited by 7
Rorex, C., Cardona, S. M., Church, K. A., Rodriguez, D., Vanegas, D., Saldivar, R. A., Faz, B. N., & Cardona, A. E. (2024) · Biomolecules · doi:10.3390/biom14050567 · Cited by 6
Jamaludin, S. Y. N., Azimi, I., Davis, F. M., Peters, A. A., Gonda, T. J., Thompson, E. W., Roberts‐Thomson, S. J., & Monteith, G. R. (2018) · Oncology Letters · doi:10.3892/ol.2018.7827 · Cited by 6
Yang, S., Wang, J.-K., Ma, W., Liu, F., Zou, R.-Q., Dai, Y.-S., Lv, T., Li, F., & Hu, H. (2023) · Annals of Surgical Oncology · doi:10.1245/s10434-023-14421-3 · Cited by 6
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Rankin, E. B., Erler, J. T., & Giaccia, A. J. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-2865-7.00003-5 · Cited by 6
Myeloid Hypoxia-Inducible Factors in Inflammatory Diseases
Aragonés, J., Elorza, A., Acosta‐Iborra, B., & Landázuri, M. O. (2011) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v31.i1.10 · Cited by 5
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Galdiero, M. R., Biswas, S. K., & Mantovani, A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_2 · Cited by 4
Steinberger, K. J., Forget, M. A., Bobko, A. A., Mihalik, N. E., Gencheva, M., Roda, J. M., Cole, S. L., Mo, X. M., Hoblitzell, E. H., Evans, R., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2001134 · Cited by 5
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Mahanti, K., Saha, J., Sarkar, D., Pramanik, A., Das, D., Mondal, P., Mahato, M., & Bhattacharyya, S. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00199 · Cited by 4
Kuwano, A., Tanaka, M., Suzuki, H., Kurokawa, M., Imoto, K., Tashiro, S., Goya, T., Kohjima, M., Kato, M., & Ogawa, Y. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2021.101068 · Cited by 4
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Swami, M. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2921 · Cited by 4
Fu, W., Liu, Y., Yin, A., Xie, L., & Yin, H. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70124 · Cited by 3
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Zhang, W., Tan, Y., Ai, J., Luo, F., Su, X., Wu, Q., Su, L., Pan, J., Zheng, Q., Li, B., et al. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5050 · Cited by 2
Ang, A. D., Vissers, M. C. M., Burgess, E. R., Currie, M. J., & Dachs, G. U. (2021) · Antioxidants · doi:10.3390/antiox10030430 · Cited by 3
Vanderhaeghen, T., Timmermans, S., Eggermont, M., Watts, D., Vandewalle, J., Wallaeys, C., Nuyttens, L., Temmerman, J. D., Hochepied, T., Dewaele, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1124011 · Cited by 3
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Metadata
- Authors
- Imtiyaz, H. Z., Williams, E. P., Hickey, M. M., Patel, S. A., Durham, A. C., Yuan, L.-J., Hammond, R., Gimotty, P. A., Keith, B., & Simon, M. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Abramson Cancer Center (US)
- Corresponding author
- Simon, M. Celeste
- Venue
- Journal of Clinical Investigation
- Published
- 2010-08-02
- Volume
- 120
- Issue
- 8
- Pages
- 2699-2714
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2912179
- OpenAlex
- W2041418689
- Semantic Scholar
- f822a56ab9aa8dcad2e6f306df8394ee6666f231
- Cited by
- 461
- References
- 116
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 22 · 2023: 26 · 2022: 38 · 2021: 45 · 2020: 33 · 2019: 27 · 2018: 29 · 2017: 18 · 2016: 32 · 2015: 23 · 2014: 36 · 2013: 29 · 2012: 32
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Cancer Research Institute
- National Institutes of Health
- Directorate for Biological Sciences
- U.S. Public Health Service (66310)
- Abramson Family Cancer Research Institute
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Keywords
- HIF-2α, HIF-1α, tumor-associated macrophages, macrophage function, hypoxia, innate immunity, endotoxemia, lipopolysaccharide, inflammatory cytokines, chemokines, macrophage migration, M-CSF receptor, CXCR4, hepatocellular carcinoma, tumor inflammation, myeloid-specific knockout
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Acute Disease, Animals, Cell Movement, Disease Models, Animal, Female, Immunity, Innate, Inflammation, Lipopolysaccharides, Macrophages, Mice, Inbred C57BL, Neoplasms, Nitric Oxide, Cytokines, Endotoxemia, Receptors, CXCR4, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins
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