Simon, M. Celeste

The tumor microenvironment

Anderson, N. M., & Simon, M. C. (2020) · Current Biology

Cancer Cells and MetastasisImmune cells in cancer

Cited by 2,718

Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 2,380

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., & Gottlieb, E. (2005) · Cancer Cell

Cancer, Hypoxia, and MetabolismEar and Head Tumors

Cited by 2,108

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 1,926

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismKruppel-like factors research

Cited by 1,693

Mop3 is an essential component of the master circadian pacemaker in mammals.

Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 1,621

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 1,545

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages

Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 1,532

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 1,489

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 1,386

The impact of O2 availability on human cancer

Bertout, J. A., Patel, S. A., & Simon, M. C. (2008) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 1,365

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature

Hemoglobinopathies and Related DisordersHematopoietic Stem Cell Transplantation

Cited by 1,308

Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 1,272

Hypoxia-Inducible Factors, Stem Cells, and Cancer

Keith, B., & Simon, M. C. (2007) · Cell

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 1,179

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 975

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

Gordan, J. D., Bertout, J. A., Hu, C.-J., Diehl, J. A., & Simon, M. C. (2007) · Cancer Cell

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 781

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 781

Hypoxia-induced energy stress regulates mRNA translation and cell growth

Liu, L., Cash, T. P., Jones, R. G., Keith, B., Thompson, C. B., & Simon, M. C. (2006) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 607

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

Mansfield, K. D., Guzy, R. D., Pan, Y., Young, R. M., Cash, T. P., Schumacker, P. T., & Simon, M. C. (2005) · Cell Metabolism

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 606

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

Rankin, E. B., Biju, M. P., Liu, Q., Unger, T. L., Rha, J., Johnson, R. S., Simon, M. C., Keith, B., & Haase, V. H. (2007) · Journal of Clinical Investigation

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 596

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

Li, B., Qiu, B., Lee, D. S. M., Walton, Z. E., Ochocki, J. D., Mathew, L. K., Mancuso, A., Gade, T. P. F., Keith, B., Nissim, I., et al. (2014) · Nature

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 535

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Mastrogiannaki, M., Matak, P., Keith, B., Simon, M. C., Vaulont, S., & Peyssonnaux, C. (2009) · Journal of Clinical Investigation

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 502

HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

Gordan, J. D., Lal, P., Dondeti, V. R., Letrero, R., Parekh, K. N., Oquendo, C. E., Greenberg, R. A., Flaherty, K. T., Rathmell, W. K., Keith, B., et al. (2008) · Cancer Cell

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 493

A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

Arsham, A. M., Howell, J. J., & Simon, M. C. (2003) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 463