Keith, Brian

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismKruppel-like factors research

Cited by 1,693

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 1,386

Hypoxia-Inducible Factors, Stem Cells, and Cancer

Keith, B., & Simon, M. C. (2007) · Cell

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 1,179

Hypoxia-induced energy stress regulates mRNA translation and cell growth

Liu, L., Cash, T. P., Jones, R. G., Keith, B., Thompson, C. B., & Simon, M. C. (2006) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 607

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

Rankin, E. B., Biju, M. P., Liu, Q., Unger, T. L., Rha, J., Johnson, R. S., Simon, M. C., Keith, B., & Haase, V. H. (2007) · Journal of Clinical Investigation

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 596

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Posey, A. D., Schwab, R. D., Boesteanu, A. C., Steentoft, C., Mandel, U., Engels, B., Stone, J. D., Madsen, T. D., Schreiber, K., Haines, K. M., et al. (2016) · Immunity

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 594

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

Li, B., Qiu, B., Lee, D. S. M., Walton, Z. E., Ochocki, J. D., Mathew, L. K., Mancuso, A., Gade, T. P. F., Keith, B., Nissim, I., et al. (2014) · Nature

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 535

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Mastrogiannaki, M., Matak, P., Keith, B., Simon, M. C., Vaulont, S., & Peyssonnaux, C. (2009) · Journal of Clinical Investigation

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 502

HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

Gordan, J. D., Lal, P., Dondeti, V. R., Letrero, R., Parekh, K. N., Oquendo, C. E., Greenberg, R. A., Flaherty, K. T., Rathmell, W. K., Keith, B., et al. (2008) · Cancer Cell

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 493

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

Imtiyaz, H. Z., Williams, E. P., Hickey, M. M., Patel, S. A., Durham, A. C., Yuan, L.-J., Hammond, R., Gimotty, P. A., Keith, B., & Simon, M. C. (2010) · Journal of Clinical Investigation

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 461

Acute postnatal ablation of Hif-2 α results in anemia

Gruber, M., Hu, C.-J., Johnson, R. S., Brown, E. J., Keith, B., & Simon, M. C. (2007) · Proceedings of the National Academy of Sciences

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 457

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

Qiu, B., Ackerman, D., Sanchez, D. J., Li, B., Ochocki, J. D., Grazioli, A., Bobrovnikova-Marjon, E., Diehl, J. A., Keith, B., & Simon, M. C. (2015) · Cancer Discovery

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 394

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q., & Haase, V. H. (2009) · Molecular and Cellular Biology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 338

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

Kapitsinou, P. P., Liu, Q., Unger, T. L., Rha, J., Davidoff, O., Keith, B., Epstein, J. A., Moores, S. L., Erickson-Miller, C. L., & Haase, V. H. (2010) · Blood

Erythropoietin and Anemia TreatmentHemoglobin structure and function

Cited by 307

HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

Bertout, J. A., Majmundar, A. J., Gordan, J. D., Lam, J. C., Ditsworth, D., Keith, B., Brown, E. J., Nathanson, K. L., & Simon, M. C. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 196

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

Mack, F. A., Rathmell, W. K., Arsham, A. M., Gnarra, J., Keith, B., & Simon, M. C. (2003) · Cancer Cell

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 160