The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
Open accessAbstract
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Islands and India has stressed the need to better understand the pathogenesis of this disease. Previous CHIKV disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. Herein, we describe what we believe to be a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease. In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHIKV disease symptoms observed in humans. In addition, the study identified macrophages as the main cellular reservoirs during the late stages of CHIKV infection in vivo. This model of CHIKV physiopathology should allow the development of new therapeutic and/or prophylactic strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152
Mogal, A., & Abdulkadir, S. A. (2006) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2005.09.008 · Cited by 67
Cited by
Chikungunya Virus Arthritis in Adult Wild-Type Mice
Gardner, J., Anraku, I., Le, T. T., Larcher, T., Major, L., Roques, P., Schroder, W. A., Higgs, S., & Suhrbier, A. (2010) · Journal of Virology · doi:10.1128/jvi.02603-09 · Cited by 438
Self-citationAlves de Souza, T., Fernandes-Santos, C., Araújo da Paixão de Oliveira, J., Tomé, L., Fiestas-Solórzano, V., Nunes, P., Guimaraes, G., Sánchez-Arcila, J., Paiva, I., de Souza, L., et al. (2022) · Pathogens · doi:10.3390/pathogens11040444 · Cited by 15
Metadata
- Authors
- Labadie, K., Larcher, T., Joubert, C., Mannioui, A., Delache, B., Brochard, P., Guigand, L., Dubreil, L., Lebon, P., Verrier, B., de Lamballerie, X., Suhrbier, A., Cherel, Y., Le Grand, R., & Roques, P.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-03-01
- Volume
- 120
- Issue
- 3
- Pages
- 894-906
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2068012691
- Cited by
- 589
- References
- 2
- FWCI
- 31.90
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. https://app.cochat.ai/papers/10.1172/jci40104
- The paper
- Labadie, K., Larcher, T., Joubert, C., Mannioui, A., Delache, B., Brochard, P., Guigand, L., Dubreil, L., Lebon, P., Verrier, B., de Lamballerie, X., Suhrbier, A., Cherel, Y., Le Grand, R., & Roques, P. (2010). Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. Journal of Clinical Investigation. https://doi.org/10.1172/jci40104
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
