The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Chikungunya Virus Arthritis in Adult Wild-Type Mice
Open accessAbstract
Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus. Here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. Rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and NK cells and the production of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ). Infection with a virus isolate from the recent Reunion Island epidemic induced significantly more mononuclear infiltrates, proinflammatory mediators, and foot swelling than did an Asian isolate from the 1960s. Primary mouse macrophages were shown to be productively infected with chikungunya virus; however, the depletion of macrophages ameliorated rheumatic disease and prolonged the viremia. Only 1 μg of an unadjuvanted, inactivated, whole-virus vaccine derived from the Asian isolate completely protected against viremia and arthritis induced by the Reunion Island isolate, illustrating that protection is not strain specific and that low levels of immunity are sufficient to mediate protection. IFN-α treatment was able to prevent arthritis only if given before infection, suggesting that IFN-α is not a viable therapy. Prior infection with Ross River virus, a related arthrogenic alphavirus, and anti-Ross River virus antibodies protected mice against chikungunya virus disease, suggesting that individuals previously exposed to Ross River virus should be protected from chikungunya virus disease. This new mouse model of chikungunya virus disease thus provides insights into pathogenesis and a simple and convenient system to test potential new interventions.
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Cites
A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential
Tsetsarkin, K. A., Vanlandingham, D. L., McGee, C. E., & Higgs, S. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030201 · Cited by 1,630
Self-citationGenome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
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Chikungunya, an epidemic arbovirosis
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Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
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Self-citationECONOMOPOULOU, A., DOMINGUEZ, M., HELYNCK, B., SISSOKO, D., WICHMANN, O., QUENEL, P., GERMONNEAU, P., & QUATRESOUS, I. (2009) · Epidemiology and Infection · doi:10.1017/s0950268808001167 · Cited by 570
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Self-citationCharacterization of Reemerging Chikungunya Virus
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Cited by
Kose, N., Fox, J. M., Sapparapu, G., Bombardi, R., Tennekoon, R. N., de Silva, A. D., Elbashir, S. M., Theisen, M. A., Humphris-Narayanan, E., Ciaramella, G., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw6647 · Cited by 202
AGPAT1 is a novel Chikungunya virus receptor on human cells
Basu, B., Sarmadhikari, D., Sharma, A., Asthana, S., Kalia, M., & Vrati, S. (2026) · Journal of Virology · doi:10.1128/jvi.01733-25
Metadata
- Authors
- Gardner, J., Anraku, I., Le, T. T., Larcher, T., Major, L., Roques, P., Schroder, W. A., Higgs, S., & Suhrbier, A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2010-08-15
- Volume
- 84
- Issue
- 16
- Pages
- 8021-8032
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2119791199
- Cited by
- 438
- References
- 50
- FWCI
- 19.68
- Type
- journal article
- Language
- en
- Open access
- green
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