The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice
Open accessAbstract
Human leukemic stem cells, like other cancer stem cells, are hypothesized to be rare, capable of incomplete differentiation, and restricted to a phenotype associated with early hematopoietic progenitors or stem cells. However, recent work in other types of tumors has challenged the cancer stem cell model. Using a robust model of xenotransplantation based on NOD/SCID/IL2Rγc-deficient mice, we confirmed that human leukemic stem cells, functionally defined by us as SCID leukemia-initiating cells (SL-ICs), are rare in acute myelogenous leukemia (AML). In contrast to previous results, SL-ICs were found among cells expressing lineage markers (i.e., among Lin+ cells), CD38, or CD45RA, all markers associated with normal committed progenitors. Remarkably, each engrafting fraction consistently recapitulated the original phenotypic diversity of the primary AML specimen and contained self-renewing leukemic stem cells, as demonstrated by secondary transplants. While SL-ICs were enriched in the Lin-CD38- fraction compared with the other fractions analyzed, SL-ICs in this fraction represented only one-third of all SL-ICs present in the unfractionated specimen. These results indicate that human AML stem cells are rare and enriched but not restricted to the phenotype associated with normal primitive hematopoietic cells. These results suggest a plasticity of the cancer stem cell phenotype that we believe has not been previously described.
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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells
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Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche
Ye, H., Adane, B., Khan, N., Sullivan, T., Minhajuddin, M., Gasparetto, M., Stevens, B., Pei, S., Balys, M., Ashton, J. M., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.06.001 · Cited by 543
Metadata
- Authors
- Sarry, J.-E., Murphy, K., Perry, R., Sanchez, P. V., Secreto, A., Keefer, C., Swider, C. R., Strzelecki, A.-C., Cavelier, C., Récher, C., Mansat-De Mas, V., Delabesse, E., Danet-Desnoyers, G., & Carroll, M.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-01-04
- Volume
- 121
- Issue
- 1
- Pages
- 384-395
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2090757708
- Cited by
- 386
- References
- 30
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Sarry, J.-E., Murphy, K., Perry, R., Sanchez, P. V., Secreto, A., Keefer, C., Swider, C. R., Strzelecki, A.-C., Cavelier, C., Récher, C., Mansat-De Mas, V., Delabesse, E., Danet-Desnoyers, G., & Carroll, M. (2011). Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci41495
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