Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells
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In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino acid uptake, steady-state levels, and catabolism are all elevated in the leukemia stem cell (LSC) population. Furthermore, LSCs isolated from de novo AML patients are uniquely reliant on amino acid metabolism for oxidative phosphorylation and survival. Pharmacological inhibition of amino acid metabolism reduces oxidative phosphorylation and induces cell death. In contrast, LSCs obtained from relapsed AML patients are not reliant on amino acid metabolism due to their ability to compensate through increased fatty acid metabolism. These findings indicate that clinically relevant eradication of LSCs can be achieved with drugs that target LSC metabolic vulnerabilities.
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The combination of venetoclax and azacitidine targets mitochondrial metabolism through inhibition of glutathionylation of complex II of the electron transport chain and diminishes uptake of global amino acids in primary patient AML stem cells.
“the combination of venetoclax (inhibitor of the anti-apoptopic protein BCL-2) and azacitidine has been shown to target mitochondrial metabolism through inhibition of the glutathionylation of complex II of the electron transport chain (45) and diminishes the uptake of global amino acids in primary patient AML stem cells (46).”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [46]
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works
Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
Merico, D., Isserlin, R., Stueker, O., Emili, A., & Bader, G. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013984 · Cited by 2,235 · see citing works
Regulation of glutathione synthesis
Lu, S. C.-L. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.05.005 · Cited by 2,131 · see citing works
Lagadinou, E. D., Sach, A., Callahan, K. P., Rossi, R. M., Neering, S. J., Minhajuddin, M., Ashton, J. M., Pei, S., Grose, V., O’Dwyer, K. M., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.013 · Cited by 1,410 · see citing works
Self-citationOncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Viale, A., Pettazzoni, P., Lyssiotis, C. A., Ying, H., Sánchez, N., Marchesini, M., Carugo, A., Green, T., Seth, S., Giuliani, V., et al. (2014) · Nature · doi:10.1038/nature13611 · Cited by 1,259 · see citing works
The key role of anaplerosis and cataplerosis for citric acid cycle function
Owen, O. E., Kalhan, S. C., & Hanson, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200006200 · Cited by 1,172 · see citing works
Konopleva, M. Y., Pollyea, D. A., Potluri, J., Chyla, B., Hogdal, L. J., Busman, T. A., McKeegan, E. M., Salem, A. H., Zhu, M., Ricker, J. L., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0313 · Cited by 1,067 · see citing works
Self-citationStem cell gene expression programs influence clinical outcome in human leukemia
Eppert, K., Takenaka, K., Lechman, E. R., Waldron, L., Nilsson, B., van Galen, P., Metzeler, K. H., Poeppl, A. G., Ling, V., Beyene, J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2415 · Cited by 1,032 · see citing works
Ishikawa, F., Yoshida, S., Saito, Y., Hijikata, A., Kitamura, H., Tanaka, S., Nakamura, R., Tanaka, T., Tomiyama, H., Saito, N., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1350 · Cited by 993 · see citing works
Hope, K. J., Jin, L., & Dick, J. E. (2004) · Nature Immunology · doi:10.1038/ni1080 · Cited by 968 · see citing works
Jang, Y.-Y., & Sharkis, S. J. (2007) · Blood · doi:10.1182/blood-2007-05-087759 · Cited by 894 · see citing works
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Suda, T., Takubo, K., & Semenza, G. L. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.09.010 · Cited by 844 · see citing works
Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.002 · Cited by 820 · see citing works
Pollyea, D. A., Stevens, B. M., Jones, C. L., Winters, A., Pei, S., Minhajuddin, M., D’Alessandro, A., Culp-Hill, R., Riemondy, K. A., Gillen, A. E., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0233-1 · Cited by 778 · see citing works
Self-citationDinardo, C. D., Pratz, K. W., Letai, A. G., Jonas, B. A., Wei, A. H., Thirman, M. J., Arellano, M. L., Frattini, M. G., Kantarjian, H. M., Popovic, R., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30010-x · Cited by 723 · see citing works
Self-citationMYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells
Sancho, P., Burgos-Ramos, E., Tavera, A., Bou Kheir, T., Jagust, P., Schoenhals, M., Barneda, D., Sellers, K., Campos-Olivas, R., Graña, O., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.015 · Cited by 722 · see citing works
Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia
Škrtić, M., Sriskanthadevan, S., Jhas, B., Gebbia, M., Wang, X., Wang, Z., Hurren, R., Jitkova, Y., Gronda, M., MacLean, N., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.10.015 · Cited by 681 · see citing works
Roesch, A., Vultur, A., Bogeski, I., Wang, H., Zimmermann, K. M., Speicher, D., Körbel, C., Laschke, M. W., Gimotty, P. A., Philipp, S. E., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.05.003 · Cited by 670 · see citing works
Lee, K., Giltnane, J. M., Balko, J. M., Schwarz, L. J., Zotano, Á. G., Hutchinson, K. E., Nixon, M. J., Estrada, M. V., Sanchez, V. M., Sanders, M. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.009 · Cited by 652 · see citing works
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
Chan, S. M., Thomas, D., Corces, M. R., Xavy, S., Rastogi, S., Hong, W., Zhao, F., Medeiros, B. C., Tyvoll, D. A., & Majeti, R. (2015) · Nature Medicine · doi:10.1038/nm.3788 · Cited by 580 · see citing works
Cramer, S. L., Saha, A., Liu, J., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S. E., Rowlinson, S. W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4232 · Cited by 541 · see citing works
Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche
Ye, H., Adane, B., Khan, N., Sullivan, T., Minhajuddin, M., Gasparetto, M., Stevens, B. M., Pei, S.-S., Balys, M., Ashton, J., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.06.001 · Cited by 509 · see citing works
Self-citationImp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cellsPreprint
Janiszewska, M., Suvà, M. L., Riggi, N., Houtkooper, R. H., Auwerx, J. H., Clément‐Schatlo, V., Radovanovic, I., Rheinbay, E., Provero, P., & Stamenkovic, I. (2012) · Genes & Development · doi:10.1101/gad.188292.112 · Cited by 451 · see citing works
Dinardo, C. D., Rausch, C. R., Benton, C. B., Kadia, T. M., Jain, N., Pemmaraju, N., Daver, N. G., Covert, W. M., Marx, K. R., Mace, M. L., et al. (2017) · American Journal of Hematology · doi:10.1002/ajh.25000 · Cited by 425 · see citing works
Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting
Konopleva, M. Y., & Jordan, C. T. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.0904 · Cited by 401 · see citing works
Self-citationCancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
Hattori, A., Tsunoda, M., Konuma, T., Kobayashi, M., Nagy, T., Glushka, J., Tayyari, F., McSkimming, D., Kannan, N., Tojo, A., et al. (2017) · Nature · doi:10.1038/nature22314 · Cited by 401 · see citing works
Smith, J., Ladi, E., Mayer-Pröschel, M., & Noble, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170209797 · Cited by 399 · see citing works
Sarry, J., Murphy, K. M., Perry, R. L., Sanchez, P. V., Secreto, A. J., Keefer, C., Swider, C. R., Strzelecki, A.-C., Cavelier, C., Récher, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41495 · Cited by 386 · see citing works
Cole, A., Wang, Z., Coyaud, É., Voisin, V., Gronda, M., Jitkova, Y., Mattson, R., Hurren, R., Babovic, S., MacLean, N., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.05.004 · Cited by 358 · see citing works
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L., Poschet, G., Nonnenmacher, Y., Barnert, A., et al. (2017) · Nature · doi:10.1038/nature24294 · Cited by 354 · see citing works
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
Pei, S., Minhajuddin, M., Adane, B., Khan, N., Stevens, B. M., Mack, S. C., Lai, S., Rich, J. N., Sheth, A. I., Shannon, K., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.05.021 · Cited by 300 · see citing works
Self-citationTherapeutic targeting of acute myeloid leukemia stem cells
Pollyea, D. A., & Jordan, C. T. (2017) · Blood · doi:10.1182/blood-2016-10-696039 · Cited by 296 · see citing works
Self-citationSaito, Y., Chapple, R. H., Lin, A. J., Kitano, A., & Nakada, D. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.08.019 · Cited by 272 · see citing works
Phang, J. M., Liu, W., Hancock, C. N., & Fischer, J. W. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000121 · Cited by 228 · see citing works
Evolution of acute myelogenous leukemia stem cell properties after treatment and progression.
Ho, T.-C., LaMere, M., Stevens, B. M., Ashton, J., Myers, J. R., O'Dwyer, K., Liesveld, J., Mendler, J. H., Guzman, M., Morrissette, J. J. D., et al. (2013) · Blood · doi:10.1182/blood-2016-02-695312 · Cited by 223 · see citing works
Self-citationTargeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells
Pei, S., Minhajuddin, M., Callahan, K. P., Balys, M. M., Ashton, J. M., Neering, S. J., Lagadinou, E. D., Corbett, C. A., Ye, H., Liesveld, J. L., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.511170 · Cited by 204 · see citing works
Self-citationAcute Myeloid Leukemia Stem Cells
Dick, J. E. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1349.001 · Cited by 189 · see citing works
Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation
Taya, Y., Ota, Y., Wilkinson, A. C., Kanazawa, A., Watarai, H., Kasai, M., Nakauchi, H., & Yamazaki, S. (2016) · Science · doi:10.1126/science.aag3145 · Cited by 189 · see citing works
Nemkov, T. G., D’Alessandro, A., & Hansen, K. C. (2015) · Amino Acids · doi:10.1007/s00726-015-2019-9 · Cited by 171 · see citing works
Self-citationTerpstra, W. E., Ploemacher, R., Prins, A., van Lom, K., Pouwels, K., Wognum, A., Wagemaker, G., Löwenberg, B., & Wielenga, J. (1996) · Blood · doi:10.1182/blood.v88.6.1944.bloodjournal8861944 · Cited by 108 · see citing works
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia
Gregory, M. A., D’Alessandro, A., Calderon, F. A., Kim, J., Nemkov, T. G., Adane, B., Rozhok, A. I., Kumar, A., Kumar, V., Pollyea, D. A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603876113 · Cited by 106 · see citing works
Self-citationConsiderations for Targeting Malignant Stem Cells in Leukemia
Guzmán, M. L., & Jordan, C. T. (2004) · Cancer Control · doi:10.1177/107327480401100216 · Cited by 81 · see citing works
Self-citationGuan, Y., & Hogge, D. E. (2000) · Leukemia · doi:10.1038/sj.leu.2401975 · Cited by 51 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, (2018). AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells. Cell Stem Cell. PMC6035102 29910151
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Stem cell programs in cancer initiation, progression, and therapy resistance
Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524 · see citing works
Pei, S., Pollyea, D. A., Gustafson, A. L., Stevens, B. M., Minhajuddin, M., Fu, R., Riemondy, K. A., Gillen, A. E., Sheridan, R. M., Kim, J., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0710 · Cited by 553 · see citing works
Self-citationTargeting Cancer Stemness in the Clinic: From Hype to Hope
Saygin, C., Matei, D., Majeti, R., Reizes, O., & Lathia, J. D. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.11.017 · Cited by 517 · see citing works
Metabolism of Amino Acids in Cancer
Wei, Z. C., Liu, X., Cheng, C., Yu, W., & Yi, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603837 · Cited by 439 · see citing works
Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications
Nazio, F., Bordi, M., Cianfanelli, V., Locatelli, F., & Cecconi, F. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0292-y · Cited by 391 · see citing works
The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells
Nechiporuk, T., Kurtz, S. E., Nikolova, O. H., Liu, T., Jones, C. L., D’Alessandro, A., Culp‐Hill, R., d’Almeida, A., Joshi, S. K., Rosenberg, M. W., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0125 · Cited by 374 · see citing works
Self-citationMitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies
Guièze, R., Liu, V. M., Rosebrock, D., Jourdain, A. A., Hernández-Sánchez, M., Martinez Zurita, A., Sun, J., Ten Hacken, E., Baranowski, K., Thompson, P. A., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.08.005 · Cited by 361 · see citing works
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML
Vetrie, D. L. P., Helgason, G. V., & Copland, M. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-019-0230-9 · Cited by 351 · see citing works
Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment
Chen, X., Glytsou, C., Zhou, H., Narang, S., Reyna, D. E., López, A., Sakellaropoulos, T., Gong, Y., Kloetgen, A., Yap, Y. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0117 · Cited by 344 · see citing works
Weng, H., Huang, F., Yu, Z., Chen, Z., Prince, E., Kang, Y., Zhou, K., Li, W., Hu, J., Fu, C., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.10.004 · Cited by 336 · see citing works
Loh, J.-J., & Ma, S. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.04.004 · Cited by 327 · see citing works
Metabolic signatures of cancer cells and stem cells
Intlekofer, A. M., & Finley, L. W. S. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0032-0 · Cited by 322 · see citing works
Marchetti, P., Fovez, Q., Germain, N., Khamari, R., & Kluza, J. (2020) · The FASEB Journal · doi:10.1096/fj.202000767r · Cited by 321 · see citing works
Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells
Stevens, B. M., Jones, C. L., Pollyea, D. A., Culp‐Hill, R., D’Alessandro, A., Winters, A. C., Krug, A., Abbott, D., Goosman, M., Pei, S., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00126-z · Cited by 312 · see citing works
Self-citationTowards precision medicine for AML
Döhner, H., Wei, A. H., & Löwenberg, B. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00509-w · Cited by 314 · see citing works
Inflammation-Induced Tumorigenesis and Metastasis
Hibino, S., Kawazoe, T., Kasahara, H., Itoh, S., Ishimoto, T., Sakata‐Yanagimoto, M., & Taniguchi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115421 · Cited by 303 · see citing works
Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11
Wang, X., Chen, Y., Wang, X., Tian, H., Wang, Y., Jin, J., Shan, Z., Liu, Y., Cai, Z., Tong, X., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0567 · Cited by 265 · see citing works
Baccelli, I., Gareau, Y., Lehnertz, B., Gingras, S., Spinella, J.-F., Corneau, S., Mayotte, N., Girard, S., Fréchette, M., Blouin-Chagnon, V., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.06.003 · Cited by 257 · see citing works
Leukemic stem cells and therapy resistance in acute myeloid leukemia
Stelmach, P., & Trumpp, A. (2023) · Haematologica · doi:10.3324/haematol.2022.280800 · Cited by 261 · see citing works
An Overview: The Diversified Role of Mitochondria in Cancer Metabolism
Liu, Y., Sun, Y., Guo, Y., Shi, X., Chen, X., Feng, W., Wu, L., Zhang, J., Yu, S., Wang, Y., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81609 · Cited by 260 · see citing works
Jones, C. L., Stevens, B. M., Pollyea, D. A., Culp‐Hill, R., Reisz, J. A., Nemkov, T. G., Gehrke, S. A., Gamboni, F., Krug, A., Winters, A. C., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.07.021 · Cited by 242 · see citing works
Self-citationAmino acid metabolism in hematologic malignancies and the era of targeted therapy
Tabe, Y., Lorenzi, P. L., & Konopleva, M. Y. (2019) · Blood · doi:10.1182/blood.2019001034 · Cited by 235 · see citing works
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy
Carter, J. L., Hege-Hurrish, K., Yang, J., Kalpage, H. A., Su, Y., Edwards, H. J., Hüttemann, M., Taub, J. W., & Ge, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00361-x · Cited by 223 · see citing works
Sharon, D. M., Cathelin, S., Mirali, S., Trani, J. M. D., Yanofsky, D. J., Keon, K. A., Rubinstein, J. L., Schimmer, A. D., Ketela, T., & Chan, S. M. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax2863 · Cited by 217 · see citing works
Zhang, Q., Riley-Gillis, B. M., Han, L., Jia, Y., Lodi, A., Zhang, H., Ganesan, S., Pan, R. A., Konoplev, S. N., Sweeney, S., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00870-3 · Cited by 202 · see citing works
Ge, T., Gu, X., Jia, R., Ge, S., Chai, P., Zhuang, A., & Fan, X. (2022) · 癌症：英文版 · doi:10.1002/cac2.12374 · Cited by 206 · see citing works
Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Giddings, E. L., Champagne, D., Wu, M.-H., Laffin, J. M., Thornton, T. M., Valença-Pereira, F., Culp‐Hill, R., Fortner, K. A., Romero, N., East, J. E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23071-6 · Cited by 204 · see citing works
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Roberts, A. W., Wei, A. H., & Huang, D. C. S. (2021) · Blood · doi:10.1182/blood.2020006785 · Cited by 203 · see citing works
Bott, A. J., Shen, J., Tonelli, C., Zhan, L., Sivaram, N., Jiang, Y.-P., Yu, X., Bhatt, V., Chiles, E., Zhong, H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.056 · Cited by 185 · see citing works
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Sharma, A., Boise, L., & Shanmugam, M. (2019) · Cancers · doi:10.3390/cancers11081144 · Cited by 189 · see citing works
Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis
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Venetoclax for AML: changing the treatment paradigm
Pollyea, D. A., Amaya, M. L., Strati, P., & Konopleva, M. Y. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000937 · Cited by 172 · see citing works
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Gregory, M. A., Nemkov, T. G., Park, H. J., Zaberezhnyy, V., Gehrke, S. A., Adane, B., Jordan, C. T., Hansen, K. C., D’Alessandro, A., & DeGregori, J. V. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3223 · Cited by 173 · see citing works
Self-citationMitochondrial metabolism as a potential therapeutic target in myeloid leukaemia
de Beauchamp, L., Himonas, E., & Helgason, G. V. (2021) · Leukemia · doi:10.1038/s41375-021-01416-w · Cited by 168 · see citing works
Cherry, E. M., Abbott, D., Amaya, M. L., McMahon, C. M., Schwartz, M., Rosser, J. A., Sato, A., Schowinsky, J. T., Sheth, A. I., Minhajuddin, M., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021005538 · Cited by 174 · see citing works
Self-citationPollyea, D. A., Pratz, K. W., Letai, A. G., Jonas, B. A., Wei, A. H., Pullarkat, V. A., Konopleva, M. Y., Thirman, M. J., Arellano, M. L., Becker, P. S., et al. (2020) · American Journal of Hematology · doi:10.1002/ajh.26039 · Cited by 167 · see citing works
Self-citationMetabolic Plasticity of Acute Myeloid Leukemia
Kreitz, J., Schönfeld, C., Seibert, M., Stolp, V., Alshamleh, I., Oellerich, T., Steffen, B., Schwalbe, H., Schnütgen, F., Kurrle, N., et al. (2019) · Cells · doi:10.3390/cells8080805 · Cited by 162 · see citing works
Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II
Jones, C. L., Stevens, B. M., D’Alessandro, A., Culp-Hill, R., Reisz, J. A., Pei, S., Gustafson, A., Khan, N., DeGregori, J., Pollyea, D. A., et al. (2019) · Blood · doi:10.1182/blood.2019898114 · Cited by 158 · see citing works
Self-citationCancer Stem Cells—Key Players in Tumor Relapse
Marzagalli, M., Fontana, F., Raimondi, M., & Limonta, P. (2021) · Cancers · doi:10.3390/cancers13030376 · Cited by 135 · see citing works
New directions for emerging therapies in acute myeloid leukemia: the next chapter
Daver, N., Wei, A. H., Pollyea, D. A., Fathi, A. T., Vyas, P., & DiNardo, C. D. (2020) · Blood Cancer Journal · doi:10.1038/s41408-020-00376-1 · Cited by 159 · see citing works
Self-citationMetabolic reprogramming and immune evasion: the interplay in the tumor microenvironment
Zhang, H., Li, S., Wang, D., Liu, S. M., Xiao, T., Gu, W., Yang, H., Wang, H. Z., Yang, M., & Chen, P. (2024) · Biomarker Research · doi:10.1186/s40364-024-00646-1 · Cited by 169 · see citing works
Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production
Lee, J. B., Khan, D. H., Hurren, R., Xu, M., Na, Y., Kang, H., Mirali, S., Wang, X., Gronda, M., Jitkova, Y., et al. (2021) · Blood · doi:10.1182/blood.2020009081 · Cited by 160 · see citing works
Jones, C. L., Sheth, A. I., & Jordan, C. T. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.013 · Cited by 153 · see citing works
Self-citationMeeting the Challenge of Targeting Cancer Stem Cells
Turdo, A., Veschi, V., Gaggianesi, M., Chinnici, A., Bianca, P., Todaro, M., & Stassi, G. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00016 · Cited by 149 · see citing works
The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance
Joshi, S. K., Nechiporuk, T., Bottomly, D., Piehowski, P., Reisz, J. A., Pittsenbarger, J., Kaempf, A. J., Gosline, S. J. C., Wang, Y.-T., Hansen, J., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.06.003 · Cited by 148 · see citing works
Self-citationMetabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells
Jagušt, P., de Luxán‐Delgado, B., Parejo-Alonso, B., & Sancho, P. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00203 · Cited by 148 · see citing works
Amaya, M. L., Sheth, A. I., Pei, S., Jones, C. L., Krug, A., Ye, H., Minhajuddin, M., Winters, A. C., Furtek, S. L., Gamboni, F., et al. (2021) · Blood · doi:10.1182/blood.2021013201 · Cited by 143 · see citing works
Self-citationCancer metabolism and carcinogenesis
Yang, J., Shay, C., Saba, N. F., & Teng, Y. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00482-x · Cited by 149 · see citing works
Therapeutic development and current uses of BCL-2 inhibition
Roberts, A. W. (2020) · Hematology · doi:10.1182/hematology.2020000154 · Cited by 134 · see citing works
Current status and future perspectives in targeted therapy of NPM1-mutated AML
Ranieri, R., Pianigiani, G., Sciabolacci, S., Perriello, V. M., Marra, A., Cardinali, V., Pierangeli, S., Milano, F., Gionfriddo, I., Brunetti, L., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01666-2 · Cited by 131 · see citing works
Dzobo, K., Senthebane, D. A., Ganz, C., Thomford, N. E., Wonkam, A., & Dandara, C. (2020) · Cells · doi:10.3390/cells9081896 · Cited by 127 · see citing works
Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation
Verovskaya, E. V., Dellorusso, P. V., & Passegue, E. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.006 · Cited by 122 · see citing works
Mitochondria as a target in cancer treatment
Liu, Y., & Shi, Y. (2020) · MedComm · doi:10.1002/mco2.16 · Cited by 120 · see citing works
Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands
Kasbekar, M., Mitchell, C. A., Proven, M. A., & Passegue, E. A. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.013 · Cited by 122 · see citing works
Bosc, C., Saland, E., Bousard, A., Gadaud, N., Sabatier, M., Cognet, G., Farge, T., Boët, E., Gotanègre, M., Aroua, N., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00264-y · Cited by 119 · see citing works
Very long chain fatty acid metabolism is required in acute myeloid leukemia
Tcheng, M., Roma, A., Ahmed, N., Smith, R. W., Jayanth, P., Minden, M. D., Schimmer, A. D., Hess, D. A., Hope, K. J., Rea, K. A., et al. (2021) · Blood · doi:10.1182/blood.2020008551 · Cited by 120 · see citing works
Self-citationMetabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets
Mishra, S. K., Millman, S. E., & Zhang, L. (2022) · Blood · doi:10.1182/blood.2022018092 · Cited by 118 · see citing works
Wang, G., Xu, J., Zhao, J., Yin, W., Liu, D., Chen, W., & Hou, X. S. (2020) · Nature Communications · doi:10.1038/s41467-019-14046-9 · Cited by 120 · see citing works
Yusuf, R., Saez, B., Sharda, A., van Gastel, N., Yu, V. W. C., Baryawno, N., Scadden, E. W., Acharya, S. S., Chattophadhyay, S., Huang, C., et al. (2020) · Blood · doi:10.1182/blood.2019001808 · Cited by 110 · see citing works
Signaling, metabolism, and cancer: An important relationship for therapeutic intervention
Vaghari‐Tabari, M., Ferns, G. A., Qujeq, D., Andevari, A. N., Sabahi, Z., & Moein, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30276 · Cited by 117 · see citing works
Zhang, L., Zhang, Y., Wang, C., Yang, Y., Ni, Y., Wang, Z., Song, T., Yao, M., Liu, Z., Chao, N., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00824-9 · Cited by 118 · see citing works
Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids
Pranzini, E., Pardella, E., Paoli, P., Fendt, S., & Taddei, M. L. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.02.004 · Cited by 115 · see citing works
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia
Moujalled, D. M., Brown, F. C., Chua, C. C., Dengler, M. A., Pomilio, G., Anstee, N. S., Litalien, V., Thompson, E. R., Morley, T., MacRaild, S., et al. (2022) · Blood · doi:10.1182/blood.2022016090 · Cited by 112 · see citing works
Pei, S., Shelton, I. T., Gillen, A. E., Stevens, B. M., Gasparetto, M., Wang, Y., Liu, L., Liu, J., Brunetti, T. M., Engel, K. L., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1297 · Cited by 112 · see citing works
Self-citationReview of Venetoclax in CLL, AML and Multiple Myeloma
Lasica, M., & Anderson, M. A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11060463 · Cited by 109 · see citing works
Waclawiczek, A., Leppä, A., Renders, S., Stumpf, K., Reyneri, C., Betz, B., Janssen, M., Shahswar, R., Donato, E., Karpova, D., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0939 · Cited by 108 · see citing works
van Gils, N., Denkers, F., & Smit, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.659253 · Cited by 105 · see citing works
Fujihara, K. M., Zhang, B. Z., Jackson, T. D., Ogunkola, M. O., Nijagal, B., Milne, J. V., Sallman, D. A., Ang, C.-S., Nikolic, I., Kearney, C. J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm9427 · Cited by 103 · see citing works
“…of the anti-apoptopic protein BCL-2) and azacitidine has been shown to target mitochondrial metabolism through inhibition of the gluta-thionylation of complex II of the electron transport chain ( 45 ) and diminishes the uptake of global amino acids in primary patient AML stem cells ( 46 ).”
Bajpai, R., Sharma, A., Achreja, A., Edgar, C. L., Wei, C., Siddiqa, A., Gupta, V. A., Matulis, S. M., McBrayer, S. K., Mittal, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15051-z · Cited by 101 · see citing works
New insights into molecules and pathways of cancer metabolism and therapeutic implications
Tang, Z., Xu, Z., Zhu, X. M., & Zhang, J. (2020) · 癌症：英文版 · doi:10.1002/cac2.12112 · Cited by 99 · see citing works
Thomas, G. E., Egan, G., García‐Prat, L., Botham, A. D., Voisin, V., Patel, P. S., Hoff, F. W., Chin, J., Nachmias, B., Kaufmann, K. B., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00925-9 · Cited by 101 · see citing works
Self-citationMalic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis
Wang, Y.-P., Sharda, A., Xu, S., van Gastel, N., Man, C. H., Choi, U., Leong, W. Z., Li, X., & Scadden, D. T. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.003 · Cited by 96 · see citing works
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis
Li, C., Wu, B., Li, Y., Chen, J., Ye, Z., Tian, X., Wang, J., Xu, X., Pan, S., Zheng, Y., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.06.004 · Cited by 96 · see citing works
Dobson, S. M., García-Prat, L., Vanner, R. J., Wintersinger, J., Waanders, E., Gu, Z., McLeod, J., Gan, O. I., Grandal, I., Payne-Turner, D., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1059 · Cited by 94 · see citing works
Trombetti, S., Cesaro, E., Catapano, R., Sessa, R., Bianco, A. L., Izzo, P., & Grosso, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052470 · Cited by 91 · see citing works
Stetson, L. C., Balasubramanian, D., Ribeiro, S. P., Stefan, T., Gupta, K., Xu, X., Fourati, S., Roe, A. J., Jackson, Z., Schauner, R., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01338-7 · Cited by 84 · see citing works
Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia
Pardieu, B., Pasanisi, J., Ling, F., Bello, R. D., Penneroux, J., Su, A. H., Joudinaud, R., Chat, L., Wu, H.-C., Duchmann, M., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01573-6 · Cited by 94 · see citing works
Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells
Raffel, S., Klimmeck, D., Falcone, M., Demir, A., Pouya, A., Zeisberger, P., Lutz, C., Tinelli, M., Bischel, O. E., Bullinger, L., et al. (2020) · Blood · doi:10.1182/blood.2019003654 · Cited by 88 · see citing works
Pollyea, D. A., Winters, A. C., McMahon, C. M., Schwartz, M., Jordan, C. T., Rabinovitch, R. A., Abbott, D., Smith, C. A., & Gutman, J. A. (2021) · Bone Marrow Transplantation · doi:10.1038/s41409-021-01476-7 · Cited by 90 · see citing works
Self-citationBakhtiyari, M., Liaghat, M., Aziziyan, F., Shapourian, H., Yahyazadeh, S., Alipour, M., Shahveh, S., Maleki‐Sheikhabadi, F., Halimi, H., Forghaniesfidvajani, R., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01282-2 · Cited by 90 · see citing works
Subedi, A., Liu, Q., Ayyathan, D. M., Sharon, D. M., Cathelin, S., Hosseini, M., Xu, C., Voisin, V., Bader, G. D., D’Alessandro, A., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2021.06.004 · Cited by 84 · see citing works
Self-citationTargeting Bcl-2 Proteins in Acute Myeloid Leukemia
Wei, Y., Cao, Y., Sun, R., Cheng, L., Xiong, X., Jin, X. K., He, X., Lu, W., & Zhao, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.584974 · Cited by 86 · see citing works
Progress in understanding the mechanisms of resistance to BCL-2 inhibitors
Xu, Y., & Ye, H. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00283-0 · Cited by 86 · see citing works
Self-citationAn In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Lin, S., Larrue, C., Scheidegger, N. K., Seong, B. K. A., Dharia, N. V., Kuljanin, M., Wechsler, C. S., Kugener, G., Robichaud, A. L., Conway, A. S., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1851 · Cited by 88 · see citing works
Self-citationRecent Metabolomics Analysis in Tumor Metabolism Reprogramming
Han, J., Li, Q., Chen, Y., & Yang, Y. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.763902 · Cited by 84 · see citing works
Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia
Wang, E., Pineda, J. M. B., Kim, W. J., Chen, S., Bourcier, J., Stahl, M. F., Hogg, S. J., Bewersdorf, J. P., Han, C., Singer, M., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.12.002 · Cited by 83 · see citing works
Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML
Tabe, Y., Konopleva, M. Y., & Andreeff, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00155 · Cited by 83 · see citing works
Targeting Metabolic Reprogramming in Acute Myeloid Leukemia
Castro, I., Sampaio‐Marques, B., & Ludovico, P. (2019) · Cells · doi:10.3390/cells8090967 · Cited by 79 · see citing works
Praharaj, P. P., Panigrahi, D. P., Bhol, C. S., Patra, S., Mishra, S. R., Mahapatra, K. K., Behera, B. P., Singh, A., Patil, S., & Bhutia, S. K. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.036 · Cited by 80 · see citing works
Venetoclax therapy and emerging resistance mechanisms in acute myeloid leukaemia
Nwosu, G. O., Ross, D. M., Powell, J. A., & Pitson, S. M. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06810-7 · Cited by 80 · see citing works
Hematopoietic stem cell aging and leukemia transformation
Díaz, P. A. C., Mistry, J. J., & Trowbridge, J. J. (2023) · Blood · doi:10.1182/blood.2022017933 · Cited by 78 · see citing works
Mitochondrial metabolism as a target for acute myeloid leukemia treatment
Panina, S., Pei, J., & Kirienko, N. V. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00253-w · Cited by 74 · see citing works
Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications
Long, N. A., Golla, U., Sharma, A., & Claxton, D. F. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10308-6 · Cited by 75 · see citing works
A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia
Zhou, F., Aroua, N., Liu, Y., Rohde, C., Cheng, J., Wirth, A.-K., Fijałkowska, D., Göllner, S., Lotze, M., Yun, H., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0210 · Cited by 77 · see citing works
DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
Kurani, H., Razavipour, S. F., Harikumar, K. B., Dunworth, M., Ewald, A. J., Nasir, A., Pearson, G. W., Booven, D. V., Zhou, Z., Azzam, D. J., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1299 · Cited by 73 · see citing works
Hematopoietic versus leukemic stem cell quiescence: Challenges and therapeutic opportunities
O’Reilly, E., Zeinabad, H. A., & Szegezdi, É. (2021) · Blood Reviews · doi:10.1016/j.blre.2021.100850 · Cited by 72 · see citing works
Wei, Y., Xiong, X., Li, X., Lu, W., He, X., Jin, X. K., Sun, R., Lyu, H., Yuan, T., Sun, T., et al. (2021) · Cancer Science · doi:10.1111/cas.15048 · Cited by 72 · see citing works
Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
Liu, C., Zou, W., Nie, D., Li, S., Chen, D., Zhou, M., Lai, P., Yang, S., Ji, S., Li, Y., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.004 · Cited by 72 · see citing works
Heterogeneity in refractory acute myeloid leukemia
Horibata, S., Gui, G., Lack, J., DeStefano, C. B., Gottesman, M. M., & Hourigan, C. S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902375116 · Cited by 69 · see citing works
- Authors
- Jones, C. L., Stevens, B. M., D'Alessandro, A., Reisz, J. A., Culp-Hill, R., Nemkov, T., Pei, S., Khan, N., Adane, B., Ye, H., Krug, A., Reinhold, D., Smith, C., DeGregori, J., Pollyea, D. A., & Jordan, C. T.
- Affiliations
- University of Colorado Anschutz (US)
- University of Colorado Denver (US)
- Corresponding author
- Jordan, Craig T.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 34
- Issue
- 5
- Pages
- 724-740.e4
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC6280965
- OpenAlex
- W2901585624
- Cited by
- 585
- References
- 46
- Citations by year
- 2026: 53 · 2025: 68 · 2024: 70 · 2023: 85 · 2022: 92 · 2021: 95 · 2020: 65 · 2019: 53 · 2018: 3
- FWCI
- 16.32
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-02-11)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- V Foundation for Cancer Research (F31CA196330-01, T2017-012)
- Colorado Clinical and Translational Sciences Institute (AEF CCTSI YR9 CO 2301425)
- National Institutes of Health
- National Cancer Institute (R01 5 R01 CA200707)
- American Cancer Society (25A5072)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- leukemia stem cells, acute myeloid leukemia, amino acid metabolism, amino acid uptake, amino acid catabolism, oxidative phosphorylation, fatty acid metabolism, metabolic vulnerability, relapsed AML, cell death, metabolic reprogramming
- MeSH terms
- Amino Acids, Animals, Antineoplastic Agents, Azacitidine, Biological Transport, Fatty Acids, Female, Glycolysis, Humans, Oxidative Phosphorylation, Sulfonamides, Neoplastic Stem Cells, Leukemia, Myeloid, Acute, Bridged Bicyclo Compounds, Heterocyclic, Proto-Oncogene Proteins c-bcl-2, Cell Line, Tumor, Lipid Metabolism, Mice, Metabolome
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