The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
FGF-dependent regulation of VEGF receptor 2 expression in mice
Open accessAbstract
Numerous studies have suggested a link between the angiogenic FGF and VEGF signaling pathways; however, the nature of this link has not been established. To evaluate this relationship, we investigated VEGF signaling in ECs with disrupted FGF signaling in vitro and in vivo. ECs lacking FGF signaling became unresponsive to VEGF, caused by downregulation of VEGF receptor 2 (VEGFR2) expression after reduced Vegfr2 enhancer activation. FGF mediated VEGFR2 expression via activation of Erk1/2. Transcriptional analysis revealed that Ets transcription factors controlled VEGFR2 expression in an FGF- and Erk1/2-dependent manner. Mice with defective FGF signaling exhibited loss of vascular integrity and reduced vascular morphogenesis. Thus, basal FGF stimulation of the endothelium is required for maintenance of VEGFR2 expression and the ability to respond to VEGF stimulation and accounts for the hierarchic control of vascular formation by FGFs and VEGF.
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Cites
The FGF family: biology, pathophysiology and therapy
Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Receptor Specificity of the Fibroblast Growth Factor Family
Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164 · cited 1×
“Hindlimb ischemia studies were carried out in mice expressing either sFGFR1-IIIc (which binds FGF1, FGF2, FGF4, FGF5, FGF6, and FGF8) or sFGFR3-IIIb (FGF1, FGF9, and FGF20) traps (17).”
BackgroundThe ETS-domain transcription factor family
Sharrocks, A. D. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35099076 · Cited by 1,086 · cited 1×
“Since Erk1/2 is known to activate several transcription factors by increasing their phosphorylation (15), we measured transcriptional activity of a reporter construct Figure 2 FGF signaling controls VEGFR2 enhancer activity and expression of other endothelial genes.”
BackgroundTranscriptional Control of Endothelial Cell Development
De Val, S., & Black, B. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.014 · Cited by 346 · cited 1×
“Since the FOX:ETS motif is involved in regulation of a number of endothelial-specific genes (8, 44), other genes may be affected as well.”
BackgroundSelf-citationRas/Mitogen-Activated Protein Kinase Signaling Activates Ets-1 and Ets-2 by CBP/p300 Recruitment
Foulds, C. E., Nelson, M. L., Blaszczak, A. G., & Graves, B. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10954-10964.2004 · Cited by 190
Ets1 and ets2 are required for endothelial cell survival during embryonic angiogenesis
Wei, G., Srinivasan, R., Cantemir-Stone, C. Z., Sharma, S. M., Santhanam, R., Weinstein, M., Muthusamy, N., Man, A. K., Oshima, R. G., Leone, G., et al. (2009) · Blood · doi:10.1182/blood-2009-03-211391 · Cited by 185
Cited by
Mechanisms and regulation of endothelial VEGF receptor signalling
Simons, M., Gordon, E., & Claesson-Welsh, L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.87 · Cited by 1,498
Self-citationBlood vessel formation and function in bone
Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 441
The molecular basis of endothelial cell plasticity
Dejana, E., Hirschi, K. K., & Simons, M. (2017) · Nature Communications · doi:10.1038/ncomms14361 · Cited by 441
Self-citationChen, P.-Y., Qin, L., Barnes, C., Charisse, K., Yi, T., Zhang, X., Ali, R., Medina, P. P., Yu, J., Slack, F. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.021 · Cited by 304
Self-citationEl‐Kenawi, A. E., & El‐Remessy, A. B. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12344 · Cited by 253
Metadata
- Authors
- Murakami, M., Nguyen, L. T., Hatanaka, K., Schachterle, W., Chen, P.-Y., Zhuang, Z. W., Black, B. L., & Simons, M.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-07-01
- Volume
- 121
- Issue
- 7
- Pages
- 2668-2678
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2028172989
- Cited by
- 181
- References
- 7
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Murakami, M., Nguyen, L. T., Hatanaka, K., Schachterle, W., Chen, P.-Y., Zhuang, Z. W., Black, B. L., & Simons, M. (2011). FGF-dependent regulation of VEGF receptor 2 expression in mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci44762
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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