The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
The molecular basis of endothelial cell plasticity
Open accessAbstract
The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also undergo hematopoietic transition giving rise to multi-lineage hematopoietic stem and progenitors while others acquire mesenchymal properties necessary for heart development. In the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input. The failure to do so leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases. A better understanding of these phenotypic changes may lead to development of new therapeutic interventions. Vascular endothelium possesses remarkable plasticity in response to cues from its surroundings, leading to great heterogeneity of endothelial cells in different vascular beds. Here the authors explain the molecular basis of endothelial plasticity during embryogenesis and in various diseases.
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Cites
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Endothelial to Mesenchymal Transition in Cardiovascular Disease
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Vascular endothelial cell development and diversity
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Serum albumin in health and disease: esterase, antioxidant, transporting and signaling properties
Belinskaia, D. A., Voronina, P. A., Shmurak, V. I., Jenkins, R. O., & Goncharov, N. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910318 · Cited by 416
Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation
Jambusaria, A., Hong, Z., Zhang, L., Srivastava, S., Jana, A., Toth, P. T., Dai, Y., Malik, A. B., & Rehman, J. (2020) · eLife · doi:10.7554/elife.51413 · Cited by 292
Metadata
- Authors
- Dejana, E., Hirschi, K. K., & Simons, M.
- Venue
- Nature Communications
- Published
- 2017-02-09
- Volume
- 8
- Issue
- 1
- Pages
- 14361-14361
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2587625705
- Cited by
- 441
- References
- 129
- FWCI
- 13.98
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
