FGF23 induces left ventricular hypertrophy

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    Nathalie Neirynck, Raymond Vanholder, Eva Schepers, Sunny Eloot, Anneleen Pletinck, Griet Glorieux · 2012 · International Urology and Nephrology
  2. Heart Failure in Patients with Chronic Kidney Disease: A Systematic Integrative Review
    Liviu Segall, Ionuţ Nistor, Adrian Constantin Covic · 2014 · BioMed Research International
  3. The PTH-Vitamin D-FGF23 axis
    Jenny E. Blau, Michael Terrence Collins · 2015 · Reviews in Endocrine and Metabolic Disorders
  4. Reduced Renal α-Klotho Expression in CKD Patients and Its Effect on Renal Phosphate Handling and Vitamin D Metabolism
    Hirokazu Sakan, Kimihiko Nakatani, Osamu Asai, Akihiro Imura, Tomohiro Tanaka, Shuhei Yoshimoto, Noriyuki Iwamoto, Norio Kurumatani, Masayuki Iwano, Yo‐ichi Nabeshima et al. · 2014 · PLoS ONE
  5. Bone: a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders
    Marc G. Vervloet, Ziad A. Massy, Vincent Matthias Brandenburg, Sandro Mazzaferro, Mario Gennaro Cozzolino, Pablo Ureña, Jordi Bover, David J.A. Goldsmith · 2014 · The Lancet Diabetes & Endocrinology
  6. Novel targets of antifibrotic and anti-inflammatory treatment in CKD
    Anne‐Émilie Declèves, Kumar Sharma · 2014 · Nature Reviews Nephrology
  7. Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community
    Johan Ärnlöv, Axel Carl Carlsson, Johan Sundström, Erik Ingelsson, Anders Olof Larsson, Lars Lind, Tobias E. Larsson · 2012 · Kidney International
  8. Direct inhibition of osteoblastic Wnt pathway by fibroblast growth factor 23 contributes to bone loss in chronic kidney disease
    Natalia Carrillo‐López, Sara Panizo, Cristina Alonso‐Montes, Pablo Román‐García, Isabel Rodrı́guez, Carlos Martínez‐Salgado, Adriana Dusso, Manuel Naves‐Díaz, Jorge Benito Cannata-Andía · 2016 · Kidney International
  9. A Prospective Cohort Study of Mineral Metabolism After Kidney Transplantation
    Myles Selig Wolf, Matthew R. Weir, Nelson P. Kopyt, Roslyn Bernstein Mannon, Jon R. Von Visger, Hongjie Deng, Susan V. Yue, Flavio G. Vincenti · 2015 · Transplantation
  10. Fibroblast Growth Factor-23 and Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS)
    Mathew, Jehu S., Sachs, Michael C., Katz, Ronit, Patton, Kristen K., Heckbert, Susan R., Hoofnagle, Andrew N., Alonso, Alvaro, Chonchol, Michel, Deo, Rajat, Ix, Joachim H. et al. · 2014 · Circulation
  11. A 12-Week, Double-Blind, Placebo-Controlled Trial of Ferric Citrate for the Treatment of Iron Deficiency Anemia and Reduction of Serum Phosphate in Patients With CKD Stages 3-5
    Geoffrey A. Block, Steven N. Fishbane, Mariano Rodríguez, Gerard Smits, Shay Shemesh, Pablo E. Pérgola, Myles Selig Wolf, Glenn Matthew Chertow · 2014 · American Journal of Kidney Diseases
  12. FGF-23 Is a Negative Regulator of Prenatal and Postnatal Erythropoiesis
    Lindsay M. Coe, Sangeetha Vadakke Madathil, Carla Casu, Beate Lanske, Stefano Rivella, Despina Sitara · 2014 · Journal of Biological Chemistry
  13. Interpreting Cardiac Troponin Results from High-Sensitivity Assays in Chronic Kidney Disease without Acute Coronary Syndrome
    Christopher R. deFilippi, Stephen L. Seliger, Walter E. Kelley, Show‐Hong Duh, Michael K. Hise, Robert H. Christenson, Myles Selig Wolf, Hanna Kim Gaggin, James L. Januzzi · 2012 · Clinical Chemistry
  14. Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets
    Simon Wöhrle, Christine Henninger, Olivier Bonny, Anne Thuery, Noémie Beluch, Nancy E. Hynes, Vito Guagnano, William R. Sellers, Francesco Hofmann, Michaela Kneissel et al. · 2012 · Journal of Bone and Mineral Research
  15. Roles of FGF Signals in Heart Development, Health, and Disease
    Nobuyuki Itoh, Hiroya Ohta, Yoshiaki Nakayama, Morichika Konishi · 2016 · Frontiers in Cell and Developmental Biology
  16. Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo
    Yue Guo, Xiaodong Zhuang, Zena Huang, Jing Zou, Da-Ya David Yang, Xun Hu, Zhimin Du, Lichun Wang, Xinxue Liao · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  17. Renal and extrarenal effects of fibroblast growth factor 23
    Marc G. Vervloet · 2018 · Nature Reviews Nephrology
  18. The basics of phosphate metabolism
    Carsten Alexander Wagner · 2023 · Nephrology Dialysis Transplantation
  19. Arterial disease in chronic kidney disease
    William Edward Moody, Nicola C. Edwards, Colin Dominic Chue, Charles Joseph Ferro, John Townend · 2012 · Heart
  20. Phosphate Toxicity in CKD: The Killer among Us
    Cynthia S. Ritter, Eduardo Slatopolsky · 2016 · Clinical Journal of the American Society of Nephrology
  21. Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice
    Wenchao Zhang, Aika Miikeda, Jonathan E. Zuckerman, Xun Jia, Sarada Charugundla, Zhiqiang Zhou, Karolina Elżbieta Kaczor‐Urbanowicz, Clara E. Magyar, Fangfei Guo, Zeneng Wang et al. · 2021 · Scientific Reports
  22. Effects of Dietary Phosphate Restriction and Phosphate Binders on FGF23 Levels in CKD
    Tamara Isakova, Allison Barchi-Chung, Gwen Enfield, Kelsey T. Smith, Gabriella Vargas, Jessica Houston, Huiliang Xie, PATRICIA W. WAHL, Eva Schiavenato, Austin R. Dosch et al. · 2013 · Clinical Journal of the American Society of Nephrology
  23. Cardiac Remodeling in Chronic Kidney Disease
    Nadine Kaesler, Anne Babler, Jürgen Floege, Rafael Kramann · 2020 · Toxins
  24. Fibroblast Growth Factor-23 and Cardiovascular Disease in the General Population
    Bryan R. Kestenbaum, Michael Charles Sachs, Andy N. Hoofnagle, David S. Siscovick, Joachim H. Ix, Cassianne Robinson‐Cohen, João A.C. Lima, Joseph F. Polak, Marc Blondon, JOHN T. RUZINSKI et al. · 2014 · Circulation Heart Failure
  25. X-Linked Hypophosphatemia and FGF23-Related Hypophosphatemic Diseases: Prospect for New Treatment
    Yuka Kinoshita, Seiji Fukumoto · 2018 · Endocrine Reviews
  26. Associations of FGF-23 and sKlotho with Cardiovascular Outcomes among Patients with CKD Stages 2–4
    Sarah Seiler, Kyrill Sebastian Rogacev, Heinz Jürgen Roth, Pagah Shafein, Insa E. Emrich, Stefan Neuhaus, Jürgen Floege, Danilo Fliser, Gunnar Henrik Heine · 2014 · Clinical Journal of the American Society of Nephrology
  27. New developments in the biology of fibroblast growth factors
    David M. Ornitz, Nobuyuki Itoh · 2022 · WIREs Mechanisms of Disease
  28. Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC)
    The CRIC Study Investigators, Ruth F. Dubin, Yongmei Li, Jiang He, Bernard G. Jaar, Radhakrishna Reddy Kallem, James Phillip Lash, Gail K. Makos, Sylvia E. Rosas, Elsayed Z. Soliman et al. · 2013 · BMC Nephrology
  29. Plasma Klotho is not related to kidney function and does not predict adverse outcome in patients with chronic kidney disease
    Sarah Seiler, Ming Wen, Heinz Jürgen Roth, Michael Fehrenz, Franziska Flügge, Esther Herath, Anja Weihrauch, Danilo Fliser, Gunnar Henrik Heine · 2012 · Kidney International
  30. The emerging role of Klotho in clinical nephrology
    Ming Chang Hu, Makoto Kuro‐o, Orson W. Moe · 2012 · Nephrology Dialysis Transplantation
  31. Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study
    Michel Chonchol, Tom Greene, Yingying Zhang, Andrew N. Hoofnagle, Alfred K. Cheung · 2015 · Journal of the American Society of Nephrology
  32. Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function
    Karolina Lindberg, Hannes Olauson, Risul Amin, Arvind Ponnusamy, Regina M. Goetz, Rebecca F. Taylor, Moosa Mohammadi, Ann E. Canfield, Karolina R. Kublickiene, Tobias E. Larsson · 2013 · PLoS ONE
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  35. Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4.
    J. Gattineni, P. Alphonse, Qiuyu Zhang, N. Mathews, C. Bates, M. Baum · 2014 · AJP - Renal Physiology
  36. Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies
    Rik Mencke, Hannes Olauson, Jan‐Luuk Hillebrands · 2017 · Advanced Drug Delivery Reviews
  37. The FGF metabolic axis
    Xiaokun Li · 2019 · Frontiers of Medicine
  38. Phosphate—a poison for humans?
    Hirotaka Komaba, Masafumi Fukagawa · 2016 · Kidney International
  39. FGF23/FGFR4-mediated left ventricular hypertrophy is reversible
    Alexander Grabner, Karla J. Schramm, Neerupma Silswal, Matt Hendrix, Christopher Yanucil, Brian A. Czaya, Saurav Singh, Myles Selig Wolf, Sven Hermann, Jörg Stypmann et al. · 2017 · Scientific Reports
  40. FGF23 and klotho at the intersection of kidney and cardiovascular disease
    Daniel L. Edmonston, Alexander Grabner, Myles Selig Wolf · 2023 · Nature Reviews Cardiology
  41. Direct, Acute Effects of Klotho and FGF23 on Vascular Smooth Muscle and Endothelium
    Isabelle Six, Hirokazu Okazaki, Priscilla Gross, Joanna Cagnard, Cédric Boudot, Julien Maizel, Tilman Bernhard Drüeke, Ziad A. Massy · 2014 · PLoS ONE
  42. Effects of Cinacalcet on Atherosclerotic and Nonatherosclerotic Cardiovascular Events in Patients Receiving Hemodialysis: The EValuation Of Cinacalcet HCl Therapy to Lower CardioVascular Events (EVOLVE) Trial
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  43. Longitudinal FGF23 Trajectories and Mortality in Patients with CKD
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  44. Chronic Renal Insufficiency Cohort Study (CRIC)
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  45. Re‐evaluation of phosphoric acid–phosphates – di‐, tri‐ and polyphosphates (E 338–341, E 343, E 450–452) as food additives and the safety of proposed extension of use
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  46. Fibroblast Growth Factor‐23 and Incident Coronary Heart Disease, Heart Failure, and Cardiovascular Mortality: The Atherosclerosis Risk In Communities Study
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  47. Rationale and Approaches to Phosphate and Fibroblast Growth Factor 23 Reduction in CKD
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  48. Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease
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  49. The Role of the Osteocyte in Bone and Nonbone Disease
    Lynda Faye Bonewald · 2016 · Endocrinology and Metabolism Clinics of North America
  50. Aging-suppressor Klotho: Prospects in diagnostics and therapeutics
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  52. FGF23 production by osteocytes
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  53. The osteocyte plays multiple roles in bone remodeling and mineral homeostasis
    Huayue Chen, Takao Senda, Kin‐ya Kubo · 2015 · Medical Molecular Morphology
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    Justin Silver, Tally Naveh‐Many · 2013 · Nature Reviews Nephrology
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  56. Klotho expression in osteocytes regulates bone metabolism and controls bone formation
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  57. Strategies for Phosphate Control in Patients With CKD
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  58. Regulation and Effects of FGF23 in Chronic Kidney Disease
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  59. Novel biological markers of bone: from bone metabolism to bone physiology
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  60. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney
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  61. Counter‐regulatory paracrine actions of FGF ‐23 and 1,25( OH ) 2 D in macrophages
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  62. FGF23 promotes myocardial fibrosis in mice through activation of β-catenin
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  72. Update on FGF23 and Klotho signaling
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  74. Tissue expression and source of circulating αKlotho
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  80. Fibroblast Growth Factor 23 and Cardiovascular Mortality after Kidney Transplantation
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  81. Cardiotoxicity of Uremic Toxins: A Driver of Cardiorenal Syndrome
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  92. Paracrine Effects of FGF23 on the Heart
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