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FGF23 induces left ventricular hypertrophy
Open accessAbstract
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiovascular disease in individuals with CKD. Elevated levels of FGF23 have been linked to greater risks of LVH and mortality in patients with CKD, but whether these risks represent causal effects of FGF23 is unknown. Here, we report that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort. FGF23 caused pathological hypertrophy of isolated rat cardiomyocytes via FGF receptor-dependent activation of the calcineurin-NFAT signaling pathway, but this effect was independent of klotho, the coreceptor for FGF23 in the kidney and parathyroid glands. Intramyocardial or intravenous injection of FGF23 in wild-type mice resulted in LVH, and klotho-deficient mice demonstrated elevated FGF23 levels and LVH. In an established animal model of CKD, treatment with an FGF-receptor blocker attenuated LVH, although no change in blood pressure was observed. These results unveil a klotho-independent, causal role for FGF23 in the pathogenesis of LVH and suggest that chronically elevated FGF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD.
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“Data from animal studies and healthy subjects indicate that longer treatment with high Pi can lead to cardiac remodeling in animals and higher blood pressure in humans [19, 35, 42].”
From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [19]
Citations
Cites
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E., & Hsu, C.-Y. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041031 · Cited by 11,369
Self-citationLang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
Prevalence of Chronic Kidney Disease in the United States
Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P., Van Lente, F., & Levey, A. S. (2007) · JAMA · doi:10.1001/jama.298.17.2038 · Cited by 4,895
Self-citationMutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Self-citationA Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Molkentin, J. D., Lu, J., Antos, C. L., Markham, B. E., Richardson, J. A., Robbins, J. M., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566
Ornitz, D. M., & Itoh, N. (2001) · Genome biology · doi:10.1186/gb-2001-2-3-reviews3005 · Cited by 1,985
Cellular signaling by fibroblast growth factor receptors
Eswarakumar, V. P., Lax, I., & Schlessinger, J. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.001 · Cited by 1,923
Regulation of cardiac hypertrophy by intracellular signalling pathways
Heineke, J., & Molkentin, J. D. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1983 · Cited by 1,890
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Research works printed but not linked: 3
- Ben-Dov, 2007, J Clin Invest., 117, 4003
- Yin, 1982, Am J Physiol., 243, H941
- Nehgme, 1997, J Clin Endocrinol Metab., 82, 2450, 10.1210/jc.82.8.2450 · DOI
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Feger, M., Ewendt, F., Strotmann, J. M., Schäffler, H., Kempe-Teufel, D. S., Glosse, P., Stangl, G. I., & Föller, M. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02036-8 · Cited by 20
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González‐Parra, E., Aceña, Á., Lorenzo, Ó., Tarín, N., González‐Casaus, M. L., Cristóbal, C., Huelmos, A. I., Mahíllo, I., Pello, A. M., Carda, R., et al. (2015) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-015-0706-y · Cited by 20
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Kwan, P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.02.001 · Cited by 20
Aceña, Á., Pello, A. M., Carda, R., Lorenzo, Ó., González‐Casaus, M. L., Blanco‐Colio, L. M., Martı́n-Ventura, J. L., Palfy, J. A., Orejas, M., Rábago, R., et al. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0649-y · Cited by 20
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Bär, L., Hase, P., & Föller, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211309 · Cited by 20
Chua, W., Law, J. P., Cardoso, V. R., Purmah, Y., Neculau, G., Qamar, M. J. U., Russell, K., Turner, A., Tull, S. P., Neháj, F., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003405 · Cited by 19
Association of Genetically Predicted Fibroblast Growth Factor-23 with Heart Failure
Akwo, E. A., Pike, M., Ertuğlu, L. A., Vartanian, N., Farber‐Eger, E. H., Lipworth, L. P., Perwad, F., Siew, E. D., Hung, A. M., Bansal, N., et al. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00960122 · Cited by 19
Minciunescu, A., Genovese, L. D., & deFilippi, C. R. (2022) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-022-01347-2 · Cited by 21
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Epidemiologic insights on the role of fibroblast growth factor 23 in cardiovascular disease
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Self-citationHong, Y. A., Lim, J. H., Kim, M. Y., Kim, Y., Yang, K. S., Chung, B. H., Chung, S., Choi, B. S., Yang, C. W., Kim, Y., et al. (2014) · Clinical and Experimental Nephrology · doi:10.1007/s10157-014-0962-5 · Cited by 20
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Chen, X., Chen, Z.-J., Ma, X., Ding, B., Ling, H., Shi, Z., & Chen, N. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.167315 · Cited by 19
Dubin, R. F., & Shah, S. J. (2016) · Current Heart Failure Reports · doi:10.1007/s11897-016-0290-z · Cited by 20
FGF23 in kidney transplant: the strange case of Doctor Jekyll and Mister Hyde
Cianciolo, G., & Cozzolino, M. G. (2016) · Clinical Kidney Journal · doi:10.1093/ckj/sfw072 · Cited by 19
Thorsen, I. S., Bleskestad, I. H., Åsberg, A., Hartmann, A., Skadberg, Ø., Brede, C., Ueland, T., Pasch, A., Reisæter, A. V., & Gøransson, L. G. (2019) · Clinical Transplantation · doi:10.1111/ctr.13517 · Cited by 20
Rodríguez-Ortiz, M. E., Alcala-Diaz, J. F., Canalejo, A., Torres-Peña, J. D., Gómez-Delgado, F., Muñoz-Castañeda, J. R., Delgado‐Lista, J., Rodríguez, M., López‐Miranda, J., & Almadén, Y. (2019) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2019.12.008 · Cited by 19
Yokomoto‐Umakoshi, M., Umakoshi, H., Miyazawa, T., Ogata, M., Sakamoto, R., & Ogawa, Y. (2020) · Bone · doi:10.1016/j.bone.2020.115777 · Cited by 19
Donate-Correa, J., Martín-Núñez, E., González-Luis, A., Ferri, C., Luis-Rodríguez, D., TAGUA, V. G., Mora-Fernández, C., & Navarro-González, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122583 · Cited by 17
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Spaich, S., Zelniker, T. A., Endres, P., Stiepak, J., Uhlmann, L., Bekeredjian, R., Chorianopoulos, E., Giannitsis, E., Backs, J., Katus, H. A., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.11.012 · Cited by 18
Yang, H., Luo, H., Tang, X., Zeng, X., Yu, Y. W., Ma, L., & Fu, P. (2016) · Biomarkers in Medicine · doi:10.2217/bmm.16.11 · Cited by 19
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Yokoyama, K., Fukagawa, M., Shigematsu, T., Akiba, T., Fujii, A., Yamauchi, A., Odani, M., & Akizawa, T. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.01.016 · Cited by 18
Ahmad, F. S., Cai, X., Kunkel, K. J., Ricardo, A. C., Lash, J. P., Raj, D. S., He, J., Anderson, A. H., Budoff, M. J., Nunes, J. A. W., et al. (2017) · American Journal of Hypertension · doi:10.1093/ajh/hpx058 · Cited by 18
Self-citationJialal, I., Camacho, F., Nathoo, B. C., Tam, P. Y., Pahwa, R., & Wu, G. G. (2017) · The Nephron journals/Nephron journals · doi:10.1159/000479300 · Cited by 18
Graham-Brown, M. P. M., Churchward, D. R., Hull, K. L., Preston, R., Pickering, W. P., Eborall, H., McCann, G. P., & Burton, J. O. (2017) · Blood Purification · doi:10.1159/000481248 · Cited by 18
Hannedouche, T. P., Fouque, D. P., & Joly, D. (2018) · Néphrologie & Thérapeutique · doi:10.1016/s1769-7255(18)30647-3 · Cited by 19
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Self-citationEwendt, F., Feger, M., & Föller, M. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02561-y · Cited by 18
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Chávez-Iñiguez, J. S., Sánchez-Villaseca, S. J., & García-Macías, L. A. (2021) · Archivos de cardiología de México · doi:10.24875/acm.20000183 · Cited by 21
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Saha, S., Sreenivas, V., & Goswami, R. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab114 · Cited by 17
Schepelmann, M., Ranieri, M., Lopez‐Fernandez, I., Webberley, T. S., Brennan, S. C., Yarova, P., Graça, J. A., Hanif, U.-K., Müller, C. J., Manhardt, T., et al. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021040585 · Cited by 17
Rajput, S., Dutta, A., Rajender, S., Mithal, A., & Chattopadhyay, N. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1098841 · Cited by 17
Torregrosa, J., Bover, J., Rodríguez, M., Parra, E. G., Arenas, M. D., Caravaca, F., González‐Casaus, M. L., Martín‐Malo, A., Navarro‐González, J. F., de Lorenzo, V., et al. (2023) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2023.03.003 · Cited by 17
Cao, C., Hu, J., Dong, Y., Zhan, R., Li, P., Su, H., Peng, Q., Wu, T., Huang, X. B., Sun, W.-H., et al. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv128 · Cited by 17
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Xu, H., Hashem, A., Witasp, A., Mencke, R., Goldsmith, D. J. A., Barany, P. F., Bruchfeld, A. N., Wernerson, A. M., Carrero, J. J., & Olauson, H. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy315 · Cited by 17
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Coppolino, G., Nicotera, R., Cernaro, V., Calimeri, S., Leonardi, G., Cosentino, S., Comi, A., Donato, C., Citraro, M. L., Provenzano, M., et al. (2019) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.13435 · Cited by 19
Memmos, E., & Papagianni, A. A. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200420102100 · Cited by 18
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Iwamoto, N., Sato, N., Nishida, M., Hashimoto, T., Kobayashi, H., Yamazaki, S., Okino, K., Nishimura, M., Takatani, T., Okamoto, Y., et al. (2015) · Clinical and Experimental Nephrology · doi:10.1007/s10157-015-1208-x · Cited by 17
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Self-citationFibroblast Growth Factors in Cardiovascular Disease
Morita, H., & Hoshiga, M. (2024) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv22025 · Cited by 16
Almroth, G., Lönn, J., Uhlin, F., Nayeri, F., Brudin, L. H., Andersson, B. A., & Hahn‐Zoric, M. (2013) · Scandinavian Journal of Immunology · doi:10.1111/sji.12082 · Cited by 16
Fibroblast growth factor 23 and acute kidney injury
Neyra, J. A., Moe, O. W., & Hu, M. C. (2014) · Pediatric Nephrology · doi:10.1007/s00467-014-3006-1 · Cited by 17
Self-citationMiyamura, M., Fujita, S.-I., Morita, H., Sakane, K., Okamoto, Y., Sohmiya, K., Hoshiga, M., & Ishizaka, N. (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0413 · Cited by 15
Negri, A. L. (2013) · International Urology and Nephrology · doi:10.1007/s11255-012-0370-2 · Cited by 16
Moody, W. E., Tomlinson, L. A., Ferro, C. J., Steeds, R. P., Mark, P. B., Zehnder, D., Tomson, C., Cockcroft, J., Wilkinson, I. B., & Townend, J. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.10.024 · Cited by 16
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Yamauchi, Y., Fujita, S.-I., Shibata, K., Morita, H., Ito, T., Sohmiya, K., Hoshiga, M., & Ishizaka, N. (2017) · International Heart Journal · doi:10.1536/ihj.16-359 · Cited by 16
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Hanudel, M. R., Laster, M. L., Ramos, G., Gales, B., & Salusky, I. B. (2018) · Pediatric Nephrology · doi:10.1007/s00467-018-3999-y · Cited by 16
Edmonston, D. L., WOJDYLA, D. M., Mehta, R. C., Cai, X., Lora, C. M., Cohen, D. L., Townsend, R. R., He, J., Go, A. S., Kusek, J. W., et al. (2019) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2019.05.026 · Cited by 16
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Vervloet, M. G. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.03.013 · Cited by 16
Chronic Kidney Disease and End Stage Renal Disease
Martinusen, D. J., Marin, J., Cheng, E., & Lau, W. (2020) · Advanced clinical pharmacy - research, development and practical applications/Advanced clinical pharmacy - research, development and practical applications · doi:10.1007/978-3-030-37655-0_4 · Cited by 17
Kuro‐o, M. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.013 · Cited by 16
Self-citationLandaluce, C. G., Aceña, Á., Pello, A. M., Martínez‐Milla, J., González‐Lorenzo, Ó., Tarín, N., Cristóbal, C., Blanco‐Colio, L. M., Martı́n-Ventura, J. L., Huelmos, A. I., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13331 · Cited by 16
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Courbon, G., & David, V. (2022) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000804 · Cited by 16
Tortorici, A. R., Narasaki, Y., You, A. S., Norris, K. C., Streja, E., Peralta, R. A., Guerrero, Y., Daza, A. C., Arora, R., Lo, R. H., et al. (2022) · Nutrients · doi:10.3390/nu14153070 · Cited by 16
Baia, L. C., van den Berg, E., Vervloet, M. G., Heilberg, I. P., Navis, G. J., Bakker, S. J. L., Geleijnse, J. M., Kromhout, D., Soedamah‐Muthu, S. S., & de Borst, M. H. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.06.006 · Cited by 16
Baralić, M., Brković, V., Stojanov, V., Stankovic, S. D., Lalić, N., Djuric, P. S., Đukanović, L., Kašiković, M., Petrović, M., Petrović, M., et al. (2018) · Journal of Medical Biochemistry · doi:10.2478/jomb-2018-0026 · Cited by 16
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Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels
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Self-citation
Metadata
- Authors
- Faul, C., Amaral, A. P., Oskouei, B., Hu, M.-C., Sloan, A., Isakova, T., Gutiérrez, O. M., Aguillon-Prada, R., Lincoln, J., Hare, J. M., Mundel, P., Morales, A., Scialla, J., Fischer, M., Soliman, E. Z., Chen, J., Go, A. S., Rosas, S. E., Nessel, L., Townsend, R. R., Feldman, H. I., St. John Sutton, M., Ojo, A., Gadegbeku, C., Di Marco, G. S., Reuter, S., Kentrup, D., Tiemann, K., Brand, M., Hill, J. A., Moe, O. W., Kuro-o, M., Kusek, J. W., Keane, M. G., & Wolf, M.
- Affiliations
- University of Miami (US)
- The University of Texas Southwestern Medical Center (US)
- University of Alabama at Birmingham (US)
- Harvard University (US)
- University of Illinois Chicago (US)
- Wake Forest University (US)
- Tulane University (US)
- University of California, San Francisco (US)
- University of Pennsylvania (US)
- University of Michigan (US)
- Temple University (US)
- University of Münster (DE)
- National Institutes of Health (US)
- ORCID
- Faul, Christian
- Amaral, Ansel P.
- Isakova, Tamara
- Gutiérrez, Orlando M.
- Lincoln, Joy
- Hare, Joshua M.
- Mundel, Peter
- Scialla, Julia
- Fischer, Michael
- Soliman, Elsayed Z.
- Chen, Jing
- Go, Alan S.
- Rosas, Sylvia E.
- Townsend, Raymond R.
- Feldman, Harold I.
- Ojo, Akinlolu
- Reuter, Stefan
- Kentrup, Dominik
- Tiemann, Klaus
- Hill, Joseph A.
- Moe, Orson W.
- Keane, Martin G.
- Wolf, Myles
- Venue
- Journal of Clinical Investigation
- Published
- 2011-11-01
- Volume
- 121
- Issue
- 11
- Pages
- 4393-4408
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3204831
- OpenAlex
- W2015668150
- Cited by
- 2,027
- References
- 92
- Citations by year
- 2026: 83 · 2025: 92 · 2024: 81 · 2023: 124 · 2022: 135 · 2021: 172 · 2020: 126 · 2019: 144 · 2018: 175 · 2017: 152 · 2016: 154 · 2015: 152 · 2014: 170 · 2013: 155 · 2012: 104
- FWCI
- 107.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- Abbott Laboratories
- Amgen
- Nephcure Foundation
- University of Miami
- University of Pennsylvania
- Health Services Research and Development
- Cleveland Clinic
- Cleveland Clinic Foundation
- Johns Hopkins University (RR025005)
- University of Texas Southwestern Medical Center
- Case Western Reserve University (UL1RR024989)
- Deutsches Krebsforschungszentrum
- Ministry of Education, India
- Stifterverband
- National Institutes of Health (RR024131, RR025005, RR05096, RR024989)
- University of Illinois at Urbana-Champaign
- University of California, San Francisco
- Leonard M. Miller School of Medicine
- National Institute on Aging (R01AG019712)
- National Institute of Diabetes and Digestive and Kidney Diseases (5U01DK06102, R01DK076116, K24DK062234, U01DK060990, 5U01 DK60980, (P30-DK-07938, R01DK081374, R01DK062472, F30DK091057, K23DK081673, K23DK087858, R01DK091392, RR024986, R01DK091218, R01DK092461, U01DK060984, U01DK060902, U01DK060980, U01DK060963, U01DK061021, U01DK061028)
- National Center for Research Resources (UL1RR024131, RR-05096, UL1RR024989, UL1RR025005, RR 024131, M01RR016500, UL1RR024986, UL1RR024134, UL1RR029879, M01RR005096, M01RR 16500, M01RR000042)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- fibroblast growth factor 23, left ventricular hypertrophy, chronic kidney disease, calcineurin/NFAT signaling, fibroblast growth factor receptor, cardiomyocyte hypertrophy, cardiovascular disease
- MeSH terms
- Fibroblast Growth Factor-23, Klotho Proteins, Adult, Aged, Animals, Disease Models, Animal, Female, Fibroblast Growth Factors, Glucuronidase, Humans, Kidney Failure, Chronic, Male, Mice, Inbred C57BL, Middle Aged, Models, Cardiovascular, Prospective Studies, Recombinant Proteins, Cohort Studies, Signal Transduction, Fibroblast Growth Factor 2, Hypertrophy, Left Ventricular, Receptors, Fibroblast Growth Factor, Mice, Knockout, Myocytes, Cardiac, Mice, Rats, Young Adult
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