The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes
Open accessAbstract
During embryonic development, insulin-like growth factor-II (IGF-II) participates in the regulation of islet growth and differentiation. We generated transgenic mice (C57BL6/SJL) expressing IGF-II in beta cells under control of the rat Insulin I promoter in order to study the role of islet hyperplasia and hyperinsulinemia in the development of type 2 diabetes. In contrast to islets from control mice, islets from transgenic mice displayed high levels of IGF-II mRNA and protein. Pancreases from transgenic mice showed an increase in beta-cell mass (about 3-fold) and in insulin mRNA levels. However, the organization of cells within transgenic islets was disrupted, with glucagon-producing cells randomly distributed throughout the core. We also observed enhanced glucose-stimulated insulin secretion and glucose utilization in islets from transgenic mice. These mice displayed hyperinsulinemia, mild hyperglycemia, and altered glucose and insulin tolerance tests, and about 30% of these animals developed overt diabetes when fed a high-fat diet. Furthermore, transgenic mice obtained from the N1 backcross to C57KsJ mice showed high islet hyperplasia and insulin resistance, but they also developed fatty liver and obesity. These results indicate that local overexpression of IGF-II in islets might lead to type 2 diabetes and that islet hyperplasia and hypersecretion of insulin might occur early in the pathogenesis of this disease.
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Cites
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
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What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes
McGarry, J. D. (1992) · Science · doi:10.1126/science.1439783 · Cited by 657
Del Prato, S., Leonetti, F., Simonson, D. C., Sheehan, P., Matsuda, M., & DeFronzo, R. A. (1994) · Diabetologia · doi:10.1007/bf00400466 · Cited by 322
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Alonso-Magdalena, P., Morimoto, S., Ripoll, C., Fuentes, E., & Nadal, A. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8451 · Cited by 632
A compendium of gene expression in normal human tissues
HSIAO, L.-L., DANGOND, F., YOSHIDA, T., HONG, R., JENSEN, R. V., MISRA, J., DILLON, W., LEE, K. F., CLARK, K. E., HAVERTY, P., et al. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.00040.2001 · Cited by 503
Keller, M. P., Choi, Y., Wang, P., Belt Davis, D., Rabaglia, M. E., Oler, A. T., Stapleton, D. S., Argmann, C., Schueler, K. L., Edwards, S., et al. (2008) · Genome Research · doi:10.1101/gr.074914.107 · Cited by 377
Molecular regulation of pancreatic β-cell mass development, maintenance, and expansion
Ackermann, A. M., & Gannon, M. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme-06-0053 · Cited by 262
Growth factors and beta cell replication
Vasavada, R. C., Gonzalez-Pertusa, J. A., Fujinaka, Y., Fiaschi-Taesch, N., Cozar-Castellano, I., & Garcia-Ocaña, A. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.08.003 · Cited by 133
Metadata
- Authors
- Devedjian, J.-C., George, M., Casellas, A., Pujol, A., Visa, J., Pelegrín, M., Gros, L., & Bosch, F.
- Venue
- Journal of Clinical Investigation
- Published
- 2000-03-15
- Volume
- 105
- Issue
- 6
- Pages
- 731-740
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2162424977
- Cited by
- 178
- References
- 3
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Devedjian, J.-C., George, M., Casellas, A., Pujol, A., Visa, J., Pelegrín, M., Gros, L., & Bosch, F. (2000). Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes. Journal of Clinical Investigation. https://doi.org/10.1172/jci5656
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