What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

Pathogenesis of NIDDM. A balanced overview.

DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085 · see citing works

Regulation of hepatic fatty acid oxidation and ketone body production

McGarry, J. D., & Foster, D. W. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002143 · Cited by 1,460 · see citing works

Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967 · see citing works

Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

Reaven, G. M., Hollenbeck, C., Jeng, C.-Y., Wu, M. S., & Chen, Y.-D. I. (1988) · Diabetes · doi:10.2337/diab.37.8.1020 · Cited by 753 · see citing works

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

Vionnet, N., Stoffel, M., Takeda, J., Yasuda, K., Bell, G. I., Zouali, H., Lesage, S., Velho, G., Iris, F., Passa, P., et al. (1992) · Nature · doi:10.1038/356721a0 · Cited by 604 · see citing works

Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase

McGarry, J., Woeltje, K. F., Kuwajima, M., & Foster, D. W. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050305 · Cited by 354 · see citing works

Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus

Vaag, A., Henriksen, J. E., & Beck-Nielsen, H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115656 · Cited by 299 · see citing works

Diabetic Hyperglycemia: Link to Impaired Glucose Transport in Pancreatic β Cells

Unger, R. H. (1991) · Science · doi:10.1126/science.2006409 · Cited by 263 · see citing works

Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones

Randle, P. J., Kerbey, A. L., & Espinal, J. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040702 · Cited by 244 · see citing works

New Antidiabetic Drugs

Bailey, C. J., & Flatt, P. R. (1990) · Medical Entomology and Zoology · Cited by 215 · see citing works

Additive Hypoglycemic Effects of Drugs That Modify Free-Fatty Acid Metabolism by Different Mechanisms in Rats With Streptozocin-Induced Diabetes

Reaven, G. M., Chang, H., & Hoffman, B. B. (1988) · Diabetes · doi:10.2337/diab.37.1.28 · Cited by 211 · see citing works

Resistance to Insulin Suppression of Plasma Free Fatty Acid Concentrations and Insulin Stimulation of Glucose Uptake in Noninsulin-Dependent Diabetes Mellitus*

Chen, Y. I., Golay, A., Swislocki, A., & Reaven, G. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-17 · Cited by 178 · see citing works

Carbohydrate and Lipid Metabolism of Skeletal Muscle in Type 2 Diabetic Patients

Falholt, K., Jensen, I., Jensen, S. L., Mortensen, H. B., Vølund, A., Hedïng, L. G., Petersen, P. N., & FALHOLT, W. (1988) · Diabetic Medicine · doi:10.1111/j.1464-5491.1988.tb00936.x · Cited by 120 · see citing works

Mechanism of palmityl coenzyme A inhibition of liver glycogen synthase.

Wititsuwannakul, D., & Kim, K. H. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41039-8 · Cited by 116 · see citing works

Modulation of hepatic glucose production by non-esterified fatty acids in Type 2 (non-insulin-dependent) diabetes mellitus

Saloranta, C., Franssila-Kallunki, A., Ekstrand, A., Taskinen, M., & Groop, L. (1991) · Diabetologia · doi:10.1007/bf00403179 · Cited by 109 · see citing works

Lilly Lecture 1978: New Perspectives in the Regulation of Ketogenesis

McGarry, J. (1979) · Diabetes · doi:10.2337/diab.28.5.517 · Cited by 86 · see citing works

Major Gene Effect for Insulin Levels in Familial NIDDM Pedigrees

Schumacher, M. C., Hasstedt, S. J., Hunt, S. C., Williams, R. R., & Elbein, S. C. (1992) · Diabetes · doi:10.2337/diab.41.4.416 · Cited by 85 · see citing works

Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus

Ratheiser, K., Schneeweiß, B., Waldhäusl, W. K., Fasching, P., Korn, A., Nowotny, P., Rohac, M., & Wolf, H. (1991) · Metabolism · doi:10.1016/0026-0495(91)90214-h · Cited by 80 · see citing works

Operation of the “Glucose‐Fatty Acid Cycle” during Experimental Elevations of Plasma Free Fatty Acid Levels in Man

Balasse, E. O., & Neef, M. A. (1974) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1974.tb00400.x · Cited by 80 · see citing works

Acute Reversal of Experimental Diabetic Ketoacidosis in the Rat with (+)-Decanoylcarnitine

McGarry, J., & Foster, D. W. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107252 · Cited by 62 · see citing works

Patients with insulinoma show insulin resistance in the absence of arterial hypertension

Pontiroli, A. E., Alberetto, M., & Pozza, G. (1992) · Diabetologia · doi:10.1007/bf00400934 · Cited by 49 · see citing works

Influence of nicotinic acid on the rates of turnover and oxidation of plasma glucose in man

BALASSE, E. O., & Neef, M. A. (1973) · Metabolism · doi:10.1016/0026-0495(73)90207-2 · Cited by 48 · see citing works

Daily amylin replacement reverses hepatic glycogen depletion in insulin‐treated streptozotocin diabetic rats

Young, A. A., Crocker, L. B., Wolfe‐Lopez, D., & Cooper, G. J. S. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80051-4 · Cited by 26 · see citing works

Muscle insulin resistance may not be a primary etiological factor in the genetically obese fa/fa rat

Zarjevski, N., Doyle, P., & Jeanrenaud, B. (1992) · Endocrinology · doi:10.1210/endo.130.3.1537306 · Cited by 25 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883 · see citing works

Diabetic Cardiomyopathy

Jia, G., Hill, M. A., & Sowers, J. R. (2018) · Circulation Research · doi:10.1161/circresaha.117.311586 · Cited by 1,838 · see citing works

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539 · see citing works

Unconventional Methods for Fabricating and Patterning Nanostructures

Younan Xia, A., Rogers, J. A., Paul, K. E., & Whitesides, G. M. (1999) · Chemical Reviews · doi:10.1021/cr980002q · Cited by 1,536 · see citing works

Banting Lecture 2001

McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435 · see citing works

Insulin action and resistance in obesity and type 2 diabetes

Czech, M. P. (2017) · Nature Medicine · doi:10.1038/nm.4350 · Cited by 1,258 · see citing works

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works

Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096 · see citing works

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038 · see citing works

New drug targets for type 2 diabetes and the metabolic syndrome

Moller, D. E. (2001) · Nature · doi:10.1038/414821a · Cited by 1,009 · see citing works

Metabolic Flexibility in Health and Disease

Goodpaster, B. H., & Sparks, L. M. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.015 · Cited by 995 · see citing works

Selective versus Total Insulin Resistance: A Pathogenic Paradox

Brown, M. S., & Goldstein, J. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.009 · Cited by 959 · see citing works

Carbohydrates in fish nutrition: effects on growth, glucose metabolism and hepatic enzymes

HEMRE, G.-I., Mommsen, T. P., & Krogdahl, Å. (2002) · Aquaculture Nutrition · doi:10.1046/j.1365-2095.2002.00200.x · Cited by 895 · see citing works

The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A. D., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14080 · Cited by 887 · see citing works

Lipotoxic diseases

Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y. K., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00010-9 · Cited by 847 · see citing works

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

Lee, Y., Hirose, H., Ohneda, M., Johnson, J. H., McGarry, J., & Unger, R. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10878 · Cited by 832 · see citing works

Tumor Necrosis Factor, Other Cytokines and Disease

Tracey, K. J., & Cerami, A. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.001533 · Cited by 794 · see citing works

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

Shimomura, I., Bashmakov, Y. K., Ikemoto, S., Horton, J. D., Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13656 · Cited by 779 · see citing works

Life without white fat: a transgenic mousePreprint

Moitra, J., Mason, M. M., Olive, M., Krylov, D. Y., Gavrilova, O., Marcus‐Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., et al. (1998) · Genes & Development · doi:10.1101/gad.12.20.3168 · Cited by 776 · see citing works

The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214080 · Cited by 765 · see citing works

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753 · see citing works

The randle cycle revisited: a new head for an old hat.

Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743 · see citing works

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats

Aitman, T. J., Glazier, A. M., Wallace, C. A., Cooper, L. D., Norsworthy, P. J., Wahid, F. N., Al-Majali, K., Trembling, P. M., Mann, C. J., Shoulders, C. C., et al. (1999) · Nature Genetics · doi:10.1038/5013 · Cited by 728 · see citing works

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

Lemberger, T., Desvergne, B., & Wahli, W. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.335 · Cited by 704 · see citing works

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

Zhou, Y. P., & Grill, V. E. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117042 · Cited by 677 · see citing works

Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach

Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664 · see citing works

Malonyl-CoA, fuel sensing, and insulin resistance

Ruderman, N. B., Saha, A. K., Vavvas, D. G., & Witters, L. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e1 · Cited by 644 · see citing works

The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance

Alonso‐Magdalena, P., Morimoto, S., Ripoll, C., Fuentes, E., & Nadal, Á. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8451 · Cited by 632 · see citing works

Metabolic Syndrome: A Clinical and Molecular Perspective

Moller, D. E., & Kaufman, K. D. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104751 · Cited by 631 · see citing works

Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and mice

Surwit, R. S., Feinglos, M. N., Rodin, J., Sutherland, A., Petro, A. E., Opara, E. C., Kuhn, C. M., & Rebuffe-Scrive, M. (1995) · Metabolism · doi:10.1016/0026-0495(95)90123-x · Cited by 618 · see citing works

Cardiovascular consequences of metabolic syndrome

Tune, J. D., Goodwill, A. G., Sassoon, D., & Mather, K. J. (2017) · Translational research · doi:10.1016/j.trsl.2017.01.001 · Cited by 618 · see citing works

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

Schmitz-Peiffer, C., Craig, D. L., & Biden, T. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24202 · Cited by 592 · see citing works

Fatty acids, lipotoxicity and insulin secretion

McGarry, J., & Dobbins, R. L. (1999) · Diabetologia · doi:10.1007/s001250051130 · Cited by 548 · see citing works

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver

Chen, G., Liang, G., Ou, J., Goldstein, J. L., & Brown, M. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404297101 · Cited by 546 · see citing works

De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose

Sanders, F., & Griffin, J. L. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12178 · Cited by 543 · see citing works

Adipose-derived resistin and gut-derived resistin-like molecule–β selectively impair insulin action on glucose production

Rajala, M. W., Obici, S., Scherer, P. E., & Rossetti, L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16521 · Cited by 525 · see citing works

Adaptation and Maladaptation of the Heart in Diabetes: Part I

Taegtmeyer, H., McNulty, P. H., & Young, M. E. (2002) · Circulation · doi:10.1161/01.cir.0000012466.50373.e8 · Cited by 517 · see citing works

The Function of Leptin in Nutrition, Weight, and Physiology

Friedman, J. M. (2002) · Nutrition Reviews · doi:10.1301/002966402320634878 · Cited by 505 · see citing works

PKC-θ knockout mice are protected from fat-induced insulin resistance

Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500 · see citing works

Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets

Schwarz, J.-M., Linfoot, P., Dare, D., & Aghajanian, K. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.43 · Cited by 496 · see citing works

Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.

Kelley, D. E., & Simoneau, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117600 · Cited by 487 · see citing works

Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk

Manco, M., Putignani, L., & Bottazzo, G. F. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0030 · Cited by 479 · see citing works

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

Prentki, M., & Corkey, B. E. (1996) · Diabetes · doi:10.2337/diab.45.3.273 · Cited by 478 · see citing works

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.

Unger, R. H., & Zhou, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s118 · Cited by 476 · see citing works

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

Katz, E. B., Stenbit, A. E., Hatton, K. S., DePinho, R. A., & Charron, M. J. (1995) · Nature · doi:10.1038/377151a0 · Cited by 467 · see citing works

Adaptation and Maladaptation of the Heart in Diabetes: Part II

Young, M. E., McNulty, P. H., & Taegtmeyer, H. (2002) · Circulation · doi:10.1161/01.cir.0000012467.61045.87 · Cited by 465 · see citing works

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443 · see citing works

Role of the liver in the control of carbohydrate and lipid homeostasis

Postic, C., Dentin, R., & Girard, J. R. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70133-7 · Cited by 441 · see citing works

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.01.009 · Cited by 436 · see citing works

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works

Diseases of liporegulation: new perspective on obesity and related disorders

Unger, R. H., & Orci, L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0590 · Cited by 429 · see citing works

Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity

Prentki, M., Joly, E. C., El-Assaad, W., & Roduit, R. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s405 · Cited by 428 · see citing works

Metabolic syndrome without obesity: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice

Paterson, J. M., Morton, N. M., Fiévet, C., Kenyon, C. J., Holmes, M. C., Staels, B., Seckl, J. R., & Mullins, J. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305524101 · Cited by 427 · see citing works

Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women

Fiehn, O., Garvey, W. T., Newman, J. W. I., Lok, K. H., Hoppel, C. L., & Adams, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015234 · Cited by 418 · see citing works

Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men

Petersen, K. F., Dufour, S., Feng, J., Befroy, D., Dziura, J., Man, C. D., Cobelli, C., & Shulman, G. I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608537103 · Cited by 403 · see citing works

Central melanocortin receptors regulate insulin action

Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G. B., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12954 · Cited by 370 · see citing works

The Hypoglycemic Effects of Hesperidin and Naringin Are Partly Mediated by Hepatic Glucose-Regulating Enzymes in C57BL/KsJ-db/db Mice

Jung, U. J., Choi, M., Lee, M., & Jeong, K. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2499 · Cited by 370 · see citing works

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

Stein, D. T., Esser, V., Stevenson, B. E., Lane, K. E., Whiteside, J. H., Daniels, M. B., Chen, S., & McGarry, J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118727 · Cited by 367 · see citing works

Ethnic differences in hepatic steatosis

Guerrero, R., Vega, G. L., Grundy, S. M., & Browning, J. D. (2008) · Hepatology · doi:10.1002/hep.22726 · Cited by 365 · see citing works

Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony

Herman, M. A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29027 · Cited by 349 · see citing works

Central melanocortin receptors regulate insulin action

Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112954 · Cited by 370 · see citing works

Leptin therapy in insulin-deficient type I diabetes

Wang, M.-Y., Chen, L., Clark, G. O., Lee, Y., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909422107 · Cited by 327 · see citing works

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells

Sakai, K., Matsumoto, K., Nishikawa, T., Suefuji, M., Nakamaru, K., Hirashima, Y., Kawashima, J., Shirotani, T., Ichinose, K., Brownlee, M., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02832-2 · Cited by 323 · see citing works

Human genetics illuminates the paths to metabolic disease

O’Rahilly, S. (2009) · Nature · doi:10.1038/nature08532 · Cited by 324 · see citing works

Unbound free fatty acid levels in human serum.

Richieri, G. V., & Kleinfeld, A. M. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39899-0 · Cited by 320 · see citing works

A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease

Chen, Z., Yu, R., Xiong, Y., Du, F.-T., & Zhu, S. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0572-9 · Cited by 319 · see citing works

Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor

Mascaró, C., Acosta, E., Ortiz, J. A., Marrero, P. F., Hegardt, F. G., & Haro, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8560 · Cited by 318 · see citing works

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

Dobbins, R. L., Szczepaniak, L. S., Bentley, B., Esser, V., Myhill, J., & McGarry, J. D. (2001) · Diabetes · doi:10.2337/diabetes.50.1.123 · Cited by 315 · see citing works

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O'Doherty, R. M., Newgard, C. B., & Unger, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14795 · Cited by 315 · see citing works

Diabetes and apoptosis: lipotoxicity

Kusminski, C. M., Shetty, S., Orci, L., Unger, R. H., & Scherer, P. E. (2009) · Apoptosis · doi:10.1007/s10495-009-0352-8 · Cited by 302 · see citing works

Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

Valera, A., Pujol, A., Pelegrín, M., & Bosch, F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9151 · Cited by 297 · see citing works

The Role of Adipose Tissue and Lipotoxicity in the Pathogenesis of Type 2 Diabetes

Cusi, K. J. (2010) · Current Diabetes Reports · doi:10.1007/s11892-010-0122-6 · Cited by 294 · see citing works

Hepatic Selective Insulin Resistance at the Intersection of Insulin Signaling and Metabolic Dysfunction-Associated Steatotic Liver Disease

Bo, T., Gao, L., Yao, Z., Shao, S., Wang, X., Proud, C. G., & Zhao, J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.006 · Cited by 293 · see citing works

Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo

Previs, S. F., Withers, D. J., Ren, J.-M., White, M. F., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006490200 · Cited by 291 · see citing works

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans

Roden, M., Stingl, H., Chandramouli, V, Schumann, W. C., Hofer, A., Landau, B. R., Nowotny, P., Waldhäusl, W., & Shulman, G. I. (2000) · Diabetes · doi:10.2337/diabetes.49.5.701 · Cited by 288 · see citing works

Unraveling the Temporal Pattern of Diet-Induced Insulin Resistance in Individual Organs and Cardiac Dysfunction in <scp>c57bl/6</scp> Mice

Park, S.-Y., Cho, Y.-R., Kim, H.-J., Higashimori, T., Danton, C., Lee, M.-K., Dey, A., Rothermel, B., Kim, Y.-B., Kalinowski, A., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3530 · Cited by 286 · see citing works

Nonalcoholic Fatty Liver Disease

Carr, R. M., Oranu, A. C., & Khungar, V. (2016) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.07.003 · Cited by 284 · see citing works

Role of nitric oxide in obesity-induced beta cell disease.

Shimabukuro, M., Ohneda, M., Lee, Y., & Unger, R. H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119534 · Cited by 282 · see citing works

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

Leavens, K. F., Easton, R., Shulman, G. I., Previs, S. F., & Birnbaum, M. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.004 · Cited by 278 · see citing works

Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels

Gremlich, S., Bonny, C., Waeber, G., & Thorens, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30261 · Cited by 276 · see citing works

Insulin signalling mechanisms for triacylglycerol storage

Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 272 · see citing works

Liporegulation in Diet-induced Obesity

Lee, Y., Wang, M.-Y., Kakuma, T., Wang, Z.-W., Babcock, E. E., McCorkle, K., Higa, M., Zhou, Y.-T., & Unger, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008553200 · Cited by 269 · see citing works

Pancreatic β-Cells in Obesity

Milburn, J. L., Hirose, H., Lee, Y. H., Nagasawa, Y., Ogawa, A., Ohneda, M., BeltrandelRio, H., Newgard, C. B., Johnson, J. H., & Unger, R. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1295 · Cited by 269 · see citing works

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis

Yu, S., Meng, S., Xiang, M., & Ma, H. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101257 · Cited by 268 · see citing works

Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism

Ivanišević, J., Zhu, Z., Plate, L., Tautenhahn, R., Chen, S. S., O'Brien, P. J., Johnson, C. H., Marletta, M. A., Patti, G. J., & Siuzdak, G. E. (2013) · Analytical Chemistry · doi:10.1021/ac401140h · Cited by 264 · see citing works

Fatty acid metabolism and insulin secretion in pancreatic beta cells

Yaney, G. C., & Corkey, B. E. (2003) · Diabetologia · doi:10.1007/s00125-003-1207-4 · Cited by 251 · see citing works

Biomarkers in diabetes: hemoglobin A1c, vascular and tissue markers

Lyons, T. J., & Basu, A. (2012) · Translational research · doi:10.1016/j.trsl.2012.01.009 · Cited by 250 · see citing works

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

Bollheimer, L. C., Skelly, R. H., Chester, M. W., McGarry, J., & Rhodes, C. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci420 · Cited by 248 · see citing works

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18917 · Cited by 244 · see citing works

Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals

Harwood, H. J., Petras, S. F., Shelly, L. D., Zaccaro, L. M., Perry, D. A., Makowski, M. R., Hargrove, D. M., Martin, K. A., Tracey, W. R., Chapman, J. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304481200 · Cited by 242 · see citing works

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

Lee, J. M., Lee, Y., Mamrosh, J. L., Busby, S. A., Griffin, P. R., Pathak, M. C., Ortlund, E. A., & Moore, D. D. (2011) · Nature · doi:10.1038/nature10111 · Cited by 241 · see citing works

New Insights into Lipid Metabolism in Non-insulin-dependent Diabetes Mellitus

Taskinen, M., Lahdenperä, S., & Syvänne, M. (1996) · Annals of Medicine · doi:10.3109/07853899608999090 · Cited by 48 · see citing works

Metabolische Störungen bei Diabetes mellitus, ihre Diagnose und Therapie

Waldhäusl, W. K. (1984) · Klinische Anästhesiologie und Intensvtherapie · doi:10.1007/978-3-642-70125-2_2

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107 · see citing works

The Central Role of Lipid Metabolism Disorders in Diabetes Mellitus: Mechanisms, Clinical Manifestations, and Emerging Therapeutic Strategies

Yang, Q., Liu, X., Zhang, T., Zhao, X., & 肖小河 (2026) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s591764 · Cited by 6 · see citing works

Lipid metabolism and insulin sensitivity

Wu, X. (2024) · Theoretical and Natural Science · doi:10.54254/2753-8818/46/20240400 · Cited by 1 · see citing works