The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

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Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

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Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8

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Knockout of the CMP–Sialic Acid Transporter SLC35A1 in Human Cell Lines Increases Transduction Efficiency of Adeno-Associated Virus 9: Implications for Gene Therapy Potency Assays

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Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile mice

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Single Tyrosine Mutation in AAV8 and AAV9 Capsids Is Insufficient to Enhance Gene Delivery to Skeletal Muscle and Heart

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Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag

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Structural Study of Aavrh.10 Receptor and Antibody Interactions

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Cardiomyopathy: pathogenesis and therapeutic interventions

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Unique Glycan Signatures Regulate Adeno-Associated Virus Tropism in the Developing Brain

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Gene Transfer in the Lung Using Recombinant Adeno‐Associated Virus

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Correction: AAV9 Targets Cone Photoreceptors in the Nonhuman Primate Retina

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Intranasal application of adeno-associated viruses: a systematic review

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New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets

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A comparison of in vivo viral targeting systems identifies adeno‐associated virus serotype 9 (AAV9) as an effective vector for genetic manipulation of Leydig cells in adult mice

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Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition

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Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs

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Chemical modification of AAV9 capsid with N-ethyl maleimide alters vector tissue tropism

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Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno‐Associated Viral Vector rAAV9P1

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A deep learning model trained on expressed transcripts across different tissue types reveals cell-type codon-optimization preferences

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Sarcoplasmic reticulum and calcium cycling targeting by gene therapy

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Adeno-associated virus-mediated delivery of genes to mouse spermatogonial stem cells †

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Tissue and cell-type-specific transduction using rAAV vectors in lung diseases

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In Vivo Evaluation of Adeno-Associated Virus Gene Transfer in Airways of Mice with Acute or Chronic Respiratory Infection

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sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma

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Adeno-Associated Virus-Mediated Gene Therapy

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Analysis of binding properties of pathogens and toxins using multivalent glycan microarrays

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Tropism of adeno-associated virus serotypes in mouse lungs via intratracheal instillation

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Neuraminidase‐mediated desialylation augments AAV9‐mediated gene expression in skeletal muscle

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Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas

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Adeno-associated virus vector hydrogel formulations for brain cancer gene therapy applications

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Tissue blood volumes and weights in adult beagle dogs.

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Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting

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Preparation and Administration of Adeno-associated Virus Vectors for Corneal Gene Delivery

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Challenges for Gene Therapy of CNS Disorders and Implications for Parkinson's Disease Therapies

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Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors

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Tracing goes viral: Viruses that introduce expression of fluorescent proteins in chemically-specific neurons

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Syndecan-4 Mediates the Cellular Entry of Adeno-Associated Virus 9

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Heparan sulfate proteoglycan affinity of adeno-associated virus vectors: Implications for retinal gene delivery

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Multiple Recombinant Adeno-Associated Viral Vector Serotypes Display Persistent In Vivo Gene Expression in Vector-Transduced Rat Stifle Joints

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Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency

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Structural basis of liver de-targeting and neuronal tropism of CNS-targeted AAV capsids

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Riboflavin transporter deficiency: AAV9-SLC52A2 gene therapy as a new therapeutic strategy

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Natural variations in AAVHSC16 significantly reduce liver tropism and maintain broad distribution to periphery and CNS

Smith, L. J., Schulman, L., Smith, S. E., van Lieshout, L. P., Barnés, C. M., Behmoiras, L., Scarpitti, M., Kivaa, M., Duong, K. L., Benard, L. O., et al. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.06.013 · Cited by 5

An acidic oligopeptide displayed on AAV2 improves axial muscle tropism after systemic delivery

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Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses

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Adeno-associated Virus as a Mammalian DNA Vector

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Enhancing transduction efficiency of adeno-associated virus 9 by cell line engineering: implication for gene therapy potency assay

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Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors

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An ace model for SARS-CoV-2 infection

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Fluorescent in vivo editing reporter (FIVER): A novel multispectral reporter of in vivo genome editingPreprint

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The hepatic Odyssey of Adeno-associated virus: from gene delivery to long-term outcomes

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The delivery challenge of adeno-associated virus vector-based gene therapies for neurological diseases

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Adeno-associated Virus-Mediated Gene Delivery Across the Blood-Brain Barrier

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Recombinant Adeno-associated Viral Vectors Serotypes 6 and 9 are Able to Transduce Human Tracheal Epithelial Cells but Not Human Induced Pluripotent Stem Cells

Belova, L., Demchenko, A. G., Kochergin-Nikitsky, K. S., Kondrateva, E. V., Slesarenko, Y. S., Salikhova, D. I., Лавров, А. В., Efremova, A. S., Bukharova, T. B., Goldshtein, D. V., et al. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00668-4 · Cited by 3

Identification of a novel neutralization epitope in rhesus AAVs

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Gene Therapy for Cardiac Arrhythmias.

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Crossing the Blood-Brain Barrier with AAVs: What’s After SMA?

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The Co-Transduction Conundrum: Improving Dual rAAV Delivery Through Co-Administration of Capsid Serotypes With Complementary Tropism

Fehrman, R. L., & Lipinski, D. M. (2025) · Translational Vision Science & Technology · doi:10.1167/tvst.14.11.38 · Cited by 2

Complement factor H inhibits endothelial cell migration through suppression of STAT3 signaling

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Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

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Preclinical Assessment of Antibody Responses to Adeno-Associated Virus (AAV) Vector-Based Capsids of AAV2, AAV5, AAV8, or AAV9 in Laboratory Cynomolgus Macaques ( Macaca fascicularis ) of Asian or Mauritian Origin

Pajaziti, B., Michgehl, U., Blazevic, D., Fimm-Todt, F., Dütting, A., Korbmacher, B., Grote-Wessels, S., Michelfelder, S., & Mecklenburg, L. (2025) · Human Gene Therapy · doi:10.1177/10430342251376043 · Cited by 2

Transduction of E13 murine neural precursor cells by non-immunogenic recombinant adeno-associated viruses induces major changes in neuronal phenotype

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Development of Next-Generation Muscle Gene Therapy AAV Vectors

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Applications of Glycan Microarrays to Functional Glycomics

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Characterizing Complex Populations of Endogenous Adeno-Associated Viruses by Single-Genome Amplification

Nambiar, K., Wang, Q., Yan, H., & Wilson, J. M. (2022) · Human Gene Therapy · doi:10.1089/hum.2022.099 · Cited by 2

Viral vectors for gene delivery

Liang, K. J., & Samulski, R. J. (2015) · doi:10.4155/fseb2013.14.165 · Cited by 2

Serotype-specific transduction of canine joint tissue explants and cultured monolayers by self-complementary adeno-associated viral vectors

Kim, A., Duerr, F. M., Phillips, J. N., Samulski, R. J., Grieger, J. C., & Goodrich, L. R. (2022) · Gene Therapy · doi:10.1038/s41434-022-00366-x · Cited by 1

In vitro system completely restores oogenesis in congenitally infertile mice

Yoshida, K., Kimura, S., Taguchi, M., Morimoto, H., Kanatsu‐Shinohara, M., Shinohara, T., & Obata, Y. (2025) · Human Reproduction · doi:10.1093/humrep/deaf194 · Cited by 1

The Integrated Approach in Patients with Spinal Muscular Atrophy in the Era of Early Diagnosis, Etiopathogenic Therapies and Multidisciplinary Standards of Care and Rehabilitation Interventions Leads to New Phenotypes

Leanca, M. C., Mirea, A., Nicolae, G., Căpitănescu, A., Munteanu, C., & Onose, G. (2025) · Life · doi:10.3390/life15111731 · Cited by 1

Adeno-Associated Virus Vectors for Gene Therapy: From Scalable Production Systems via Serotype-Specific Glycan Interaction Patterns to Gene Transfer Applications

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Integrated AAV optimization enables efficient gene delivery to kidney in murine and human tissuePreprint

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Sensing of Endogenous Nucleic Acids by the Innate Immune System during Viral Infection: A Dissertation

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Improving lentiviral vector-mediated gene transfer by understanding cellular barriers

Oakland, M., McCray, P. B., Maury, W. J., Davidson, B. L., Klingelhutz, A. J., & Perlman, S. M. (2013) · doi:10.17077/etd.f63i1jvz

High Throughput Screening for the Enhancement of Adeno-Associated Virus Type 2 Transduction

Wallen, A. J. (2011) · ScholarlyCommons (University of Pennsylvania)

The role of Connexin45 in the pathogenesis of ventricular tachyarrhythmia

Fahmy, P. (2015) · The Sydney eScholarship Repository (The University of Sydney)

And one to bind them all

Chiorini, J. A. (2016) · Oral Diseases · doi:10.1111/odi.12495

Biology of AAV Vectors in the Central Nervous System

Murlidharan, G. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/cr64-be62

Bioengineering Adeno-Associated Viral Vectors for Cardiac-Targeted Gene Therapy Applications

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Understanding mechanisms of Adeno-associated virus vector transduction through pharmacological and biological approaches

Nicolson, S. C. (2014) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/gbv4-z740

AAV-Nrf2 Mediated Rescue of Oxidative Stress in Mouse Models

Liang, K. J. (2015) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/tmc2-r921

Mouse Models of Allergic Airways Disease

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Minimally invasive routes of AAV administration to treat GM1 gangliosidosis

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A Novel Retinal Gene Therapy Strategy for Batten Disease and Beyond

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The Wire

(2011) · Human Gene Therapy · doi:10.1089/hum.2011.2508

JoVE Video Dataset

Benyamini, B., Esbin, M. N., Whitney, O. N., Walther, N., & Maurer, A. C. (2023) · doi:10.3791/65572-v

Transcription Factor MAFG Protects Mice from High-Fat Diet–Induced Atherosclerosis by Inhibiting Endothelial Cell ApoptosisPreprint

Ma, S., Xu, X., Huo, Z., Zhang, X., Wang, G., & Wang, M. (2026) · Research Square · doi:10.21203/rs.3.rs-8841340/v1

Terminal glucose as a receptor for adeno-associated virus 44.9

Pasquale, G. D., Tehrani, H., Shinder, I., Afione, S. A., & Chiorini, J. A. (2026) · Journal of Virology · doi:10.1128/jvi.00254-25

Mitochondrial physiology within myelinated axons in health and disease : an energetic interplay between counterparts

van Hameren, G. (2018) · theses.fr (ABES) · doi:10.70675/71c15a42zb6d9z4edazb7c1zd3f51e09c949

Krüppel-like factor 14 enhances fatty acid oxidation to combat pulmonary fibrosis

Ren, J., Wan, R., Zhou, S., Ma, X., Zhu, C., Ma, J., Chen, J., Zhao, L., & Wu, W. (2026) · Respiratory Research · doi:10.1186/s12931-026-03662-x

Efficient and safe lung gene delivery using AAV6.2FF in neonatal pigs demonstrates pediatric translational potential

Zielinska, N., Howard, E. L., Yang, C., Stevens, B. A. Y., Goens, M. M., Pei, Y., Thompson, B., Caswell, J., Thébaud, B., Wey, D., et al. (2026) · Molecular Therapy Advances · doi:10.1016/j.omta.2026.201739

QSP model for AAV-mediated antibody delivery in rat brain

Liu, S., Chowdhury, E. A., Wu, S., Meno‐Tetang, G. M. L., & Shah, D. K. (2026) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-026-10051-w

Shifting AAV9 tropism by binding moiety insertion enhances transduction of tumor cell lines and human glioblastoma explants

Rothschild‐Gronau, C., Borchert, P., Radukic, M. T., Haverkamp, L., Coras, R., Simon, M., & Müller, K. M. (2026) · Scientific Reports · doi:10.1038/s41598-026-62481-8

Snail-shRNA in AAV9 inhibited EMT and pulmonary fibrosis in silica-instilled mice

Wang, Y., Hu, E., Li, S., Zhao, J., Zhu, Z., Tian, L., & Wang, Y. (2026) · Toxicology Letters · doi:10.1016/j.toxlet.2026.113214

Terminal N-Linked Galactose Is the Primary Receptor for Adeno-associated Virus 9

Shen, S., Bryant, K. D., Brown, S. M., Randell, S. H., & Asokan, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.210922 · Cited by 297

Terminal n-linked galactose is the primary receptor for adeno-associated virus

Randell, S. H., Asokan, A., Brown, S. M., Shen, S., & Bryant, K. D. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/dg3r-g349 · Cited by 3

Understanding and Manipulating AAV-Glycan Interactions

Shen, S. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/dp83-0987

Identification of the Galactose Binding Domain of the Adeno-Associated Virus Serotype 9 Capsid

Bell, C. L., Gurda, B. L., Vliet, K. V., Agbandje‐McKenna, M., & Wilson, J. M. (2012) · Journal of Virology · doi:10.1128/jvi.00448-12 · Cited by 142

Glycan Binding Avidity Determines the Systemic Fate of Adeno-Associated Virus Type 9

Shen, S., Bryant, K. D., Sun, J., Brown, S. M., Troupes, A. N., Pulicherla, N., & Asokan, A. (2012) · Journal of Virology · doi:10.1128/jvi.01155-12 · Cited by 62