The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
Open accessAbstract
TGF-beta plays an important role in lung fibrosis, which is a major cause of suffering and death seen in pulmonary disease. Smad7 has been recently identified as an antagonist of TGF-beta signaling. To investigate whether this novel molecule can be exploited for therapy of lung fibrosis, we determined the effect of exogenous Smad7, introduced by a recombinant human type 5 adenovirus vector, on bleomycin-induced lung fibrosis in mice. C57BL/6 mice with bleomycin-induced lungs received an intratracheal injection of a recombinant adenovirus carrying mice Smad7 cDNA. These mice demonstrated suppression of type I precollagen mRNA, reduced hydroxyproline content, and no morphological fibrotic responses in the lungs when compared with mice administered adenovirus carrying Smad6 cDNA. In addition, we found that expression of Smad7 transgene blocked Smad2 phosphorylation induced by bleomycin in mouse lungs. These data indicated that gene transfer of Smad7 (but not Smad6) prevented bleomycin-induced lung fibrosis, suggesting that Smad7 may have applicability in the treatment of pulmonary fibrosis.
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Cites
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TGF-β signalling from cell membrane to nucleus through SMAD proteins
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Self-citationTransforming Growth Factor β in Tissue Fibrosis
Epstein, F. H., Border, W. A., & Noble, N. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411103311907 · Cited by 3,069
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
Nakao, A., Afrakhte, M., Morn, A., Nakayama, T., Christian, J. L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N.-E., Heldin, C.-H., et al. (1997) · Nature · doi:10.1038/39369 · Cited by 1,809
Self-citationHayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.-Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Wrana, J. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80303-7 · Cited by 1,334
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
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Self-citationSmad6 inhibits signalling by the TGF-β superfamily
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Cited by
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
Self-citationmiR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
Liu, G., Friggeri, A., Yang, Y., Milosevic, J., Ding, Q., Thannickal, V. J., Kaminski, N., & Abraham, E. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100035 · Cited by 935
Roles of TGF-beta in hepatic fibrosis
Gressner, A. M. (2002) · Frontiers in Bioscience · doi:10.2741/a812 · Cited by 783
TGF-β in progression of liver disease
Dooley, S., & ten Dijke, P. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1246-y · Cited by 718
Smad3 as a mediator of the fibrotic response
Flanders, K. C. (2004) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2004.00377.x · Cited by 608
Metadata
- Authors
- Nakao, A., Fujii, M., Matsumura, R., Kumano, K., Saito, Y., Miyazono, K., & Iwamoto, I.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-07-01
- Volume
- 104
- Issue
- 1
- Pages
- 5-11
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2058278041
- Cited by
- 405
- References
- 36
- FWCI
- 19.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nakao, A., Fujii, M., Matsumura, R., Kumano, K., Saito, Y., Miyazono, K., & Iwamoto, I. (1999). Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci6094
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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