The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
Open accessAbstract
Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, such as Crohn's disease and colorectal cancer. Here, we show that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice. Loss of either Nod2 or RIP2 resulted in a proinflammatory microenvironment that enhanced epithelial dysplasia following chemically induced injury. The condition could be improved by treatment with antibiotics or an anti-interleukin-6 receptor-neutralizing antibody. Genotype-dependent disease risk was communicable via maternally transmitted microbiota in both Nod2-deficient and WT hosts. Furthermore, reciprocal microbiota transplantation reduced disease risk in Nod2-deficient mice and led to long-term changes in intestinal microbial communities. Conversely, disease risk was enhanced in WT hosts that were recolonized with dysbiotic fecal microbiota from Nod2-deficient mice. Thus, we demonstrated that licensing of dysbiotic microbiota is a critical component of disease risk. Our results demonstrate that NOD2 has an unexpected role in shaping a protective assembly of gut bacterial communities and suggest that manipulation of dysbiosis is a potential therapeutic approach in the treatment of human intestinal disorders.
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Metadata
- Authors
- Couturier-Maillard, A., Secher, T., Rehman, A., Normand, S., De Arcangelis, A., Haesler, R., Huot, L., Grandjean, T., Bressenot, A., Delanoye-Crespin, A., Gaillot, O., Schreiber, S., Lemoine, Y., Ryffel, B., Hot, D., Nùñez, G., Chen, G., Rosenstiel, P., & Chamaillard, M.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-01-02
- Volume
- 123
- Issue
- 2
- Pages
- 700-11
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1996148181
- Cited by
- 572
- References
- 52
- FWCI
- 25.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Couturier-Maillard, A., Secher, T., Rehman, A., Normand, S., De Arcangelis, A., Haesler, R., Huot, L., Grandjean, T., Bressenot, A., Delanoye-Crespin, A., Gaillot, O., Schreiber, S., Lemoine, Y., Ryffel, B., Hot, D., Nùñez, G., Chen, G., Rosenstiel, P., & Chamaillard, M. (2013). NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. Journal of Clinical Investigation. https://doi.org/10.1172/jci62236
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
