Cited by 328Iron Metabolism and DisordersErythropoietin and Anemia TreatmentHemoglobin structure and function

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Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

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Liu, Qingdu, Davidoff, Olena, Niss, Knut, Haase, Volker H.·2012·Journal of Clinical Investigation

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Abstract

Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via increased erythropoietin (EPO) synthesis in kidney and liver. Hepcidin, a small polypeptide produced by hepatocytes, plays a central role in regulating iron uptake by promoting internalization and degradation of ferroportin, the only known cellular iron exporter. Hypoxia suppresses hepcidin, thereby enhancing intestinal iron uptake and release from internal stores. While HIF, a central mediator of cellular adaptation to hypoxia, directly regulates renal and hepatic EPO synthesis under hypoxia, the molecular basis of hypoxia/HIF-mediated hepcidin suppression in the liver remains unclear. Here, we used a genetic approach to disengage HIF activation from EPO synthesis and found that HIF-mediated suppression of the hepcidin gene (Hamp1) required EPO induction. EPO induction was associated with increased erythropoietic activity and elevated serum levels of growth differentiation factor 15. When erythropoiesis was inhibited pharmacologically, Hamp1 was no longer suppressed despite profound elevations in serum EPO, indicating that EPO by itself is not directly involved in Hamp1 regulation. Taken together, we provide in vivo evidence that Hamp1 suppression by the HIF pathway occurs indirectly through stimulation of EPO-induced erythropoiesis.

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Authors: Liu, Q., Davidoff, O., Niss, K., & Haase, V. H.
Affiliations: Vanderbilt University (US)
MilliporeSigma (United States) (US)
Corresponding author: Haase, Volker H.
ORCID: Haase, Volker H.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2012-11-01
Volume: 122
Issue: 12
Pages: 4635-4644
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci63924
PMC: PMC3533545
OpenAlex: W2002549547
Cited by: 328
References: 51
Citations by year: 2026: 10 · 2025: 18 · 2024: 18 · 2023: 26 · 2022: 40 · 2021: 25 · 2020: 28 · 2019: 19 · 2018: 22 · 2017: 28 · 2016: 28 · 2015: 20 · 2014: 29 · 2013: 16
FWCI: 13.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (R01-DK080821)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080821, R01DK081646, P30DK020593)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: hypoxia-inducible factor, hepcidin, erythropoietin, erythropoiesis, iron metabolism, ferroportin, growth differentiation factor 15, hypoxia, iron absorption, liver
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Animals, Erythropoiesis, Erythropoietin, Gene Expression Regulation, Humans, Liver, Procollagen-Proline Dioxygenase, Gene Expression, Mice, Knockout, Hepatocytes, Antimicrobial Cationic Peptides, Cell Line, Tumor, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Von Hippel-Lindau Tumor Suppressor Protein, Hypoxia-Inducible Factor 1, alpha Subunit, Growth Differentiation Factor 15, Hepcidins, Hypoxia-Inducible Factor-Proline Dioxygenases

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Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

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