Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · cited 6× · see citing works

Simplified mammalian DNA isolation procedure

Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497 · see citing works

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1777 · Cited by 1,026 · cited 1× · see citing works

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854 · see citing works

Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

Ruzankina, Y., Pinzon‐Guzman, C., Asare, A., Ong, T., Pontano, L. L., Cotsarelis, G., Zediak, V. P., Velez, M., Bhandoola, A., & Brown, E. J. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.03.002 · Cited by 780 · see citing works

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

Andriopoulos Jr, B., Corradini, E., Xia, Y., Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y., et al. (2009) · Nature Genetics · doi:10.1038/ng.335 · Cited by 769 · see citing works

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Schödel, J., Oikonomopoulos, S., Ragoussis, J., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2011) · Blood · doi:10.1182/blood-2010-10-314427 · Cited by 724 · see citing works

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)

Peyssonnaux, C., Zinkernagel, A. S., Schuepbach, R. A., Rankin, E., Vaulont, S., Haase, V. H., Nizet, V., & Johnson, R. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31370 · Cited by 639 · see citing works

Forging a field: the golden age of iron biology.

Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623 · see citing works

The Role of Hepcidin in Iron Metabolism

Nemeth, E., & Ganz, T. (2009) · Acta Haematologica · doi:10.1159/000243791 · Cited by 607 · see citing works

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

Rankin, E. B., Biju, M. P., Liu, Q., Unger, T. L., Rha, J., Johnson, R. S., Simon, M. C., Keith, B., & Haase, V. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30117 · Cited by 596 · see citing works

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., & Roth, M.-P. (2009) · Nature Genetics · doi:10.1038/ng.320 · Cited by 587 · see citing works

The serine protease TMPRSS6 is required to sense iron deficiency

Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., et al. (2008) · Science · doi:10.1126/science.1157121 · Cited by 578 · see citing works

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

Silvestri, L., Pagani, A., Nai, A., De Domenico, I., Kaplan, J., & Camaschella, C. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.012 · Cited by 555 · see citing works

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Ang, S. O., Chen, H., Hirota, K., Gordeuk, V. R., Jelinek, J., Guan, Y., Liu, E., Sergueeva, A. I., Miasnikova, G. Y., Mole, D., et al. (2002) · Nature Genetics · doi:10.1038/ng1019 · Cited by 510 · see citing works

Suppression of hepcidin during anemia requires erythropoietic activity

Pak, M., Lopez, M. A., Gabayan, V., Ganz, T., & Rivera, S. (2006) · Blood · doi:10.1182/blood-2006-06-028787 · Cited by 472 · see citing works

Erythropoietin after a century of research: younger than ever

JELKMANN, W. E. B. (2007) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2007.00818.x · Cited by 365 · see citing works

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

Tanno, T., Porayette, P., Sripichai, O., Noh, S.-J., Byrnes, C., Bhupatiraju, A., Lee, Y. T., Goodnough, J. B., Harandi, O., Ganz, T., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195503 · Cited by 352 · see citing works

Hypoxic regulation of erythropoiesis and iron metabolism

Haase, V. H. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00174.2010 · Cited by 347 · see citing works

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q., & Haase, V. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00200-09 · Cited by 338 · see citing works

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A.-S., & Enns, C. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.010 · Cited by 326 · see citing works

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

Silvestri, L., Pagani, A., & Camaschella, C. (2008) · Blood · doi:10.1182/blood-2007-07-100677 · Cited by 311 · see citing works

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Gardenghi, S., Marongiu, M. F., Ramos, P., Guy, E. C., Breda, L., Chadburn, A., Liu, Y.-F., Amariglio, N., Rechavi, G., Rachmilewitz, E. A., et al. (2007) · Blood · doi:10.1182/blood-2006-09-048868 · Cited by 307 · see citing works

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

Kapitsinou, P. P., Liu, Q., Unger, T. L., Rha, J., Davidoff, O., Keith, B., Epstein, J. A., Moores, S. L., Erickson-Miller, C. L., & Haase, V. H. (2010) · Blood · doi:10.1182/blood-2010-02-270322 · Cited by 307 · see citing works

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα

Pinto, J. P., Ribeiro, S., Pontes, H., Thowfeequ, S., Tosh, D., Carvalho, F. D., & Porto, G. (2008) · Blood · doi:10.1182/blood-2007-08-106195 · Cited by 239 · see citing works

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

Ramos, E., Kautz, L., Rodriguez, R., Hansen, M., Gabayan, V. R., Ginzburg, Y. Z., Roth, M., Nemeth, E., & Ganz, T. (2011) · Hepatology · doi:10.1002/hep.24178 · Cited by 235 · see citing works

Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo

Liu, Y. M., Pop, R., Sadegh, C., Brugnara, C., Haase, V. H., & Socolovsky, M. (2006) · Blood · doi:10.1182/blood-2005-11-4458 · Cited by 215 · see citing works

β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

Ginzburg, Y., & Rivella, S. (2011) · Blood · doi:10.1182/blood-2011-03-283614 · Cited by 201 · see citing works

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

Ashby, D. R., Gale, D. P., Busbridge, M., Murphy, K. G., Duncan, N. D., Cairns, T. D., Taube, D. H., Bloom, S. R., Tam, F. W. K., Chapman, R., et al. (2010) · Haematologica · doi:10.3324/haematol.2009.013136 · Cited by 191 · cited 1× · see citing works

Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1

McMahon, S., Grondin, F., McDonald, P. P., Richard, D. E., & Dubois, C. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413248200 · Cited by 170 · see citing works

Reactivation of hepatic EPO synthesis in mice after PHD loss

Minamishima, Y. A., & Kaelin, W. G. (2010) · Science · doi:10.1126/science.1192811 · Cited by 163 · see citing works

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

Mastrogiannaki, M., Matak, P., Mathieu, J. R. R., Delga, S., Mayeux, P., Vaulont, S., & Peyssonnaux, C. (2011) · Haematologica · doi:10.3324/haematol.2011.056119 · Cited by 161 · see citing works

Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project

Piperno, A., Galimberti, S., Mariani, R., Pelucchi, S., Ravasi, G., Lombardi, C., Bilo, G., Revera, M., Giuliano, A., Faini, A., et al. (2011) · Blood · doi:10.1182/blood-2010-08-299859 · Cited by 151 · see citing works

Growth differentiation factor 15 in erythroid health and disease

Tanno, T., Noel, P., & Miller, J. L. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328337b52f · Cited by 139 · see citing works

Inactivation of the Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Suppresses von Hippel-Lindau Disease-Associated Vascular Tumors in Mice

Rankin, E. B., Higgins, D. F., Walisser, J. A., Johnson, R. S., Bradfield, C. A., & Haase, V. H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3163-3172.2005 · Cited by 137 · see citing works

Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I

Tamary, H., Shalev, H., Perez-Avraham, G., Zoldan, M., Levi, I., Swinkels, D. W., Tanno, T., & Miller, J. L. (2008) · Blood · doi:10.1182/blood-2008-06-165738 · Cited by 135 · see citing works

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

Zhang, A., Anderson, S. A., Wang, J., Yang, F., DeMaster, K., Ahmed, R., Nizzi, C. P., Eisenstein, R. S., Tsukamoto, H., & Enns, C. A. (2010) · Blood · doi:10.1182/blood-2010-06-287292 · Cited by 117 · see citing works

Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors

Lakhal‐Littleton, S., Schödel, J., Townsend, A., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173096 · Cited by 113 · see citing works

von Hippel–Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2α signaling and splenic erythropoiesis

Hickey, M. M., Lam, J. C., Bezman, N. A., Rathmell, W. K., & Simon, M. C. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32614 · Cited by 110 · see citing works

Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts

Ramirez, J., Schaad, O., Durual, S., Cossali, D., Docquier, M., Beris, P., Descombes, P., & Matthes, T. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07441.x · Cited by 96 · see citing works

Regulation of growth differentiation factor 15 expression by intracellular iron

Lakhal, S., Talbot, N. P., Crosby, A., Stoepker, C., Townsend, A. R. M., Robbins, P. A., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2009) · Blood · doi:10.1182/blood-2008-07-170431 · Cited by 95 · see citing works

Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors

Volke, M., Gale, D. P., Maegdefrau, U., Schley, G., Klanke, B., Bosserhoff, A.-K., Maxwell, P. H., Eckardt, K.-U., & Warnecke, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007875 · Cited by 93 · see citing works

Regulation of hepcidin expression at high altitude

Talbot, N. P., Lakhal, S., Smith, T. G., Privat, C., Nickol, A. H., Rivera-Ch, M., León-Velarde, F., Dorrington, K. L., Mole, D. R., & Robbins, P. A. (2012) · Blood · doi:10.1182/blood-2011-03-341776 · Cited by 93 · see citing works

2-Oxoglutarate-dependent oxygenases control hepcidin gene expression

Braliou, G. G., Falzacappa, M. V. V., Chachami, G., Casanovas, G., Muckenthaler, M. U., & Simos, G. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.12.021 · Cited by 67 · see citing works

Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency

Finkenstedt, A., Bianchi, P., Theurl, I., Vogel, W., Witcher, D. R., Wroblewski, V. J., Murphy, A. T., Zanella, A., & Zoller, H. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07535.x · Cited by 51 · see citing works

Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression

Gordeuk, V. R., Miasnikova, G. Y., Sergueeva, A. I., Niu, X., Nouraie, M., Okhotin, D. J., Polyakova, L. A., Ammosova, T., Nekhai, S., Ganz, T., et al. (2011) · Blood · doi:10.1182/blood-2011-03-345512 · Cited by 51 · see citing works

Loss of the von Hippel Lindau Tumor Suppressor Disrupts Iron Homeostasis in Renal Carcinoma Cells

Alberghini, A., Recalcati, S., Tacchini, L., Santambrogio, P., Campanella, A., & Cairo, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500971200 · Cited by 41 · see citing works

Expression of growth differentiation factor 15 is not elevated in individuals with iron deficiency secondary to volunteer blood donation

Tanno, T., Rabel, A., Lee, Y. T., Yau, Y. Y., Leitman, S. F., & Miller, J. L. (2010) · Transfusion · doi:10.1111/j.1537-2995.2010.02601.x · Cited by 34 · see citing works

A mouse model for an erythropoietin-deficiency anemia

Zeigler, B. M., Vajdos, J., Qin, W., Loverro, L., & Niß, K. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004788 · Cited by 26 · see citing works

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,834 · see citing works

Systemic Iron Homeostasis

Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122 · see citing works

Identification of erythroferrone as an erythroid regulator of iron metabolism

Kautz, L., Jung, G., Valore, E. V., Rivella, S., Nemeth, E., & Ganz, T. (2014) · Nature Genetics · doi:10.1038/ng.2996 · Cited by 1,127 · see citing works

Regulation of erythropoiesis by hypoxia-inducible factors

Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787 · see citing works

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors: A Potential New Treatment for Anemia in Patients With CKD

Gupta, N., & Wish, J. B. (2017) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2016.12.011 · Cited by 447 · see citing works

Regulation of the Iron Homeostatic Hormone Hepcidin

Sangkhae, V., & Nemeth, E. (2017) · Advances in Nutrition · doi:10.3945/an.116.013961 · Cited by 446 · see citing works

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress

Koskenkorva-Frank, T. S., Weiss, G., Koppenol, W. H., & Burckhardt, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.001 · Cited by 406 · see citing works

The IRP/IRE system in vivo: insights from mouse models

Wilkinson, N., & Pantopoulos, K. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00176 · Cited by 366 · see citing works

Anaemia in kidney disease: harnessing hypoxia responses for therapy

Koury, M. J., & Haase, V. H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.82 · Cited by 313 · see citing works

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

Cho, S. H., Raybuck, A. L., Stengel, K. R., Wei, M., Beck, T. C., Volanakis, E. J., Thomas, J. W., Hiebert, S. W., Haase, V. H., & Boothby, M. R. (2016) · Nature · doi:10.1038/nature19334 · Cited by 307 · see citing works

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

Maxwell, P. H., & Eckardt, K. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.193 · Cited by 286 · see citing works

The Regulation of Iron Absorption and Homeostasis.

Wallace, D. F. (2016) · PubMed Central · Cited by 255 · see citing works

Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis

Singh, A. K., Carroll, K., Perkovic, V., Solomon, S. D., Jha, V., Johansen, K. L., Lópes, R. D., Macdougall, I. C., Obrador, G. T., Waikar, S. S., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2113379 · Cited by 254 · see citing works

Oxidative Stress and the Homeodynamics of Iron Metabolism

Bresgen, N., & Eckl, P. (2015) · Biomolecules · doi:10.3390/biom5020808 · Cited by 247 · see citing works

Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease

Pérgola, P. E., Spinowitz, B., Hartman, C., Maroni, B. J., & Haase, V. H. (2016) · Kidney International · doi:10.1016/j.kint.2016.07.019 · Cited by 239 · see citing works

The regulation of iron transport

Frazer, D. M., & Anderson, G. J. (2013) · BioFactors · doi:10.1002/biof.1148 · Cited by 215 · see citing works

Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

Babitt, J. L., Eisenga, M. F., Haase, V. H., Kshirsagar, A. V., Levin, A., Locatelli, F., Małyszko, J., Swinkels, D. W., Tarng, D., Cheung, M., et al. (2021) · Kidney International · doi:10.1016/j.kint.2021.03.020 · Cited by 222 · see citing works

Iron regulation by hepcidin

Zhao, N., Zhang, A., & Enns, C. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67225 · Cited by 210 · see citing works

Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders

Steinbicker, A. U., & Muckenthaler, M. U. (2013) · Nutrients · doi:10.3390/nu5083034 · Cited by 196 · see citing works

Hypoxia-inducible factor–prolyl hydroxylase inhibitors in the treatment of anemia of chronic kidney disease

Haase, V. H. (2021) · Kidney International Supplements · doi:10.1016/j.kisu.2020.12.002 · Cited by 203 · see citing works

Iron Balance and the Role of Hepcidin in Chronic Kidney Disease

Ganz, T., & Nemeth, E. (2016) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2016.02.001 · Cited by 191 · see citing works

Hypoxia-inducible factors link iron homeostasis and erythropoiesis

Shah, Y. M., & Xie, L. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.12.031 · Cited by 187 · see citing works

Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience

Sanghani, N. S., & Haase, V. H. (2019) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2019.04.004 · Cited by 187 · see citing works

Iron Status and the Acute Post-Exercise Hepcidin Response in Athletes

Peeling, P., Sim, M., Badenhorst, C. E., DAWSON, B. T., Govus, A. D., Abbiss, C. R., Swinkels, D. W., & Trinder, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093002 · Cited by 171 · see citing works

The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation

Marques, O., Weiß, G., & Muckenthaler, M. U. (2022) · Blood · doi:10.1182/blood.2021013472 · Cited by 171 · see citing works

HIF‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism

Haase, V. H. (2017) · Hemodialysis International · doi:10.1111/hdi.12567 · Cited by 161 · see citing works

Hepcidin-ferroportin axis in health and disease

Ginzburg, Y. Z. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.002 · Cited by 165 · see citing works

Erythropoietic regulators of iron metabolism

Ganz, T. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.003 · Cited by 153 · see citing works

Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with β-thalassemia major: a longitudinal study

Pasricha, S., Frazer, D. M., Bowden, D. K., & Anderson, G. J. (2013) · Blood · doi:10.1182/blood-2012-12-471441 · Cited by 154 · see citing works

Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease

Sugahara, M., Tanaka, T., & Nangaku, M. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.035 · Cited by 148 · see citing works

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

Sonnweber, T., Nachbaur, D., Schroll, A., Nairz, M., Seifert, M., Demetz, E., Haschka, D., Mitterstiller, A.-M., Kleinsasser, A., Burtscher, M., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305317 · Cited by 145 · see citing works

Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis

Scindia, Y., Dey, P., Thirunagari, A., Liping, H., Rosin, D. L., Floris, M., Okusa, M. D., & Swaminathan, S. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014101037 · Cited by 141 · see citing works

Ironing out mechanisms of iron homeostasis and disorders of iron deficiency

Koleini, N., Shapiro, J. S., Geier, J., & Ardehali, H. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148671 · Cited by 145 · see citing works

Hypoxia-inducible factors in CD4 + T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

Cho, S. H., Raybuck, A. L., Blagih, J., Kemboi, E., Haase, V. H., Jones, R. G., & Boothby, M. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811702116 · Cited by 138 · see citing works

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Schwartz, A. J., Goyert, J. W., Solanki, S. A., Kerk, S. A., Chen, B., Castillo, C., Hsu, P. P., Do, B. T., Singhal, R., Dame, M. K., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00406-7 · Cited by 133 · see citing works

Molecular liaisons between erythropoiesis and iron metabolism

Kautz, L., & Nemeth, E. (2014) · Blood · doi:10.1182/blood-2014-05-516252 · Cited by 134 · see citing works

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation

Wilkinson, N., & Pantopoulos, K. (2013) · Blood · doi:10.1182/blood-2013-03-492454 · Cited by 133 · see citing works

Hepcidin

Liu, J. L., Sun, B., Yin, H.-J., & Liu, S. (2016) · Medicine · doi:10.1097/md.0000000000003150 · Cited by 138 · see citing works

Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome

Shenoy, N. K., Vallumsetla, N., Rachmilewitz, E. A., Verma, A., & Ginzburg, Y. Z. (2014) · Blood · doi:10.1182/blood-2014-03-563221 · Cited by 123 · see citing works

Adaptation of iron requirement to hypoxic conditions at high altitude

Gassmann, M., & Muckenthaler, M. U. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00248.2015 · Cited by 123 · see citing works

Iron deficiency anemia in celiac disease

Freeman, H. J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i31.9233 · Cited by 122 · see citing works

Dysregulated iron metabolism in polycythemia vera: etiology and consequences

Ginzburg, Y. Z., Feola, M., Zimran, E., Várkonyi, J., Ganz, T., & Hoffman, R. (2018) · Leukemia · doi:10.1038/s41375-018-0207-9 · Cited by 118 · see citing works

Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia

Agoro, R., Montagna, A., Goetz, R. M., Aligbe, O., Singh, G. K., Coe, L. M., Mohammadi, M., Rivella, S., & Sitara, D. (2018) · The FASEB Journal · doi:10.1096/fj.201700667r · Cited by 117 · see citing works

METABOLISM OF IRON STORES.

Saito, H. (2014) · Europe PMC (PubMed Central) · doi:10.18999/nagjms.76.3-4.235 · Cited by 115 · see citing works

Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis

Meadowcroft, A. M., Čižman, B., Holdstock, L., Biswas, N., Johnson, B. M., Jones, D., Nossuli, A. K. K., Lepore, J. J., Aarup, M., & Cobitz, A. R. (2018) · Clinical Kidney Journal · doi:10.1093/ckj/sfy014 · Cited by 111 · see citing works

Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin

Kobayashi, H., Liu, Q., Binns, T. C., Urrutia, A. A., Davidoff, O., Kapitsinou, P. P., Pfaff, A. S., Olauson, H., Wernerson, A. M., Fogo, A. B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83551 · Cited by 104 · see citing works

Recommendations by the Asian Pacific society of nephrology ( APSN ) on the appropriate use of HIF‐PH inhibitors

Yap, D. Y. H., McMahon, L. P., Hao, C., Hu, N., Okada, H., Suzuki, Y., Kim, S. G., Lim, S. K., Vareesangthip, K., Hung, C., et al. (2020) · Nephrology · doi:10.1111/nep.13835 · Cited by 105 · see citing works

Clinical iron deficiency disturbs normal human responses to hypoxia

Frise, M. C., Cheng, H., Nickol, A. H., Curtis, M. K., Pollard, K. A., Roberts, D. J., Ratcliffe, P. J., Dorrington, K. L., & Robbins, P. A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85715 · Cited by 102 · see citing works

Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease

Kaplan, J., Sharma, N., & Dikdan, S. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020389 · Cited by 104 · see citing works

Abnormal erythropoiesis and the pathophysiology of chronic anemia

Koury, M. J. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.01.002 · Cited by 96 · see citing works

Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor–Prolyl Hydroxylase Inhibitor for Anemia

Ariazi, J. L., Duffy, K. J., Adams, D. F., Fitch, D. M., Luo, L., Pappalardi, M. B., Biju, M. P., DiFilippo, E. H., Shaw, T., Wiggall, K., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.242503 · Cited by 93 · see citing works

Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH

Zhang, J., Wang, Y., Fan, M., Guan, Y., Zhang, W., Huang, F., Zhang, Z., Li, X., Yuan, B., Liu, W., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.05.008 · Cited by 94 · see citing works

Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders

Xu, Y., Alfaro-Magallanes, V. M., & Babitt, J. L. (2020) · British Journal of Haematology · doi:10.1111/bjh.17252 · Cited by 94 · see citing works

Peritubular Capillary Rarefaction: An Underappreciated Regulator of CKD Progression

Kida, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218255 · Cited by 89 · see citing works

Regulators of hepcidin expression

Roth, M., Meynard, D., & Coppin, H. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.005 · Cited by 84 · see citing works

Regulation of Hepcidin by Erythropoiesis: The Story So Far

Pasricha, S., McHugh, K., & Drakesmith, H. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050731 · Cited by 81 · see citing works

The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients

Zumbrennen‐Bullough, K. B., & Babitt, J. L. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft443 · Cited by 80 · see citing works

NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis

Duarte, T. L., Talbot, N. P., & Drakesmith, H. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8148 · Cited by 77 · see citing works

Therapeutic potential of hepcidin − the master regulator of iron metabolism

Vyoral, D., & Petrák, J. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.010 · Cited by 79 · see citing works

Regulation of systemic iron homeostasis

Finberg, K. E. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32835f5a47 · Cited by 72 · see citing works

Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes

Tojo, Y., Sekine, H., Hirano, I., Pan, X., Souma, T., Tsujita, T., Kawaguchi, S., Takeda, N., Takeda, K., Fong, G., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00161-15 · Cited by 70 · see citing works

Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations

Semenza, G. L. (2022) · Annual Review of Medicine · doi:10.1146/annurev-med-042921-102602 · Cited by 74 · see citing works

Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin

Farsijani, N., Liu, Q., Kobayashi, H., Davidoff, O., Sha, F., Fandrey, J., Ikizler, T. A., O'Connor, P. M., & Haase, V. H. (2016) · Journal of Clinical Investigation · doi:10.1172/jci74997 · Cited by 67 · see citing works

Hepcidin and sports anemia

Kong, W.-N., Gao, G., & Chang, Y.-Z. (2014) · Cell & Bioscience · doi:10.1186/2045-3701-4-19 · Cited by 67 · see citing works

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Pasricha, S., Lim, P. J., Duarte, T. L., Casu, C., Oosterhuis, D., Mleczko‐Sanecka, K., Suciu, M., da Silva, A. R., Al-Hourani, K., Arezes, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00500-z · Cited by 65 · see citing works

Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease

Liang, R. H.-S., & Ghaffari, S. (2016) · British Journal of Haematology · doi:10.1111/bjh.14194 · Cited by 66 · see citing works

Effects of an acute exercise bout on serum hepcidin levels

Domínguez, R., Sánchez-Oliver, A., Mata-Ordoñez, F., Feria-Madueño, A., Grimaldi-Puyana, M., López-Samanes, Á., & Pérez-López, A. (2018) · Nutrients · doi:10.3390/nu10020209 · Cited by 64 · see citing works

Therapeutic Advances in Regulating the Hepcidin/Ferroportin Axis

Hawula, Z. J., Wallace, D. F., Subramaniam, V. N., & Rishi, G. (2019) · Pharmaceuticals · doi:10.3390/ph12040170 · Cited by 62 · see citing works

Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies

Haase, V. H. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.004 · Cited by 64 · see citing works

Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease

Hasegawa, S., Tanaka, T., & Nangaku, M. (2018) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000431 · Cited by 62 · see citing works

Iron Status and Physical Performance in Athletes

Solberg, A., & Reikvam, H. (2023) · Life · doi:10.3390/life13102007 · Cited by 57 · see citing works

Anaemia, iron homeostasis and pulmonary hypertension: a review

Sonnweber, T., Pizzini, A., Tancevski, I., Löffler‐Ragg, J., & Weiß, G. (2020) · Internal and Emergency Medicine · doi:10.1007/s11739-020-02288-1 · Cited by 58 · see citing works

Now a Nobel gas: oxygen

Fandrey, J., Schödel, J., Eckardt, K., Katschinski, D. M., & Wenger, R. H. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02334-8 · Cited by 54 · see citing works

Iron metabolism and management: focus on chronic kidney disease

Agarwal, A. K. (2021) · Kidney International Supplements · doi:10.1016/j.kisu.2020.12.003 · Cited by 57 · see citing works

Iron, ferroptosis, and new insights for prevention in acute kidney injury

Borawski, B., & Małyszko, J. (2020) · Advances in Medical Sciences · doi:10.1016/j.advms.2020.06.004 · Cited by 54 · see citing works

Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylase Inhibitors

Locatelli, F., Minutolo, R., Nicola, L. D., & Vecchio, L. D. (2022) · Drugs · doi:10.1007/s40265-022-01783-3 · Cited by 53 · see citing works

Role of hepcidin‐ferroportin axis in the pathophysiology, diagnosis, and treatment of anemia of chronic inflammation

Langer, A. L., & Ginzburg, Y. Z. (2017) · Hemodialysis International · doi:10.1111/hdi.12543 · Cited by 54 · see citing works

Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions

Cui, R., Gale, R. P., Zhu, G., Xu, Z., Qin, T., Zhang, Y., Huang, G., Li, B., Fang, L., Zhang, H., et al. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.01.016 · Cited by 52 · see citing works

Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease

Natale, P., Palmer, S. C., Jauré, A., Hodson, E. M., Ruospo, M., Cooper, T. E., Hahn, D., Saglimbene, V. M., Craig, J. C., & Strippoli, G. F. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013751.pub2 · Cited by 50 · see citing works

Update on iron metabolism and molecular perspective of common genetic and acquired disorder, hemochromatosis

Yun, S., & Vincelette, N. D. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.02.006 · Cited by 51 · see citing works

Intestinal Inflammation Modulates Expression of the Iron-Regulating Hormone Hepcidin Depending on Erythropoietic Activity and the Commensal Microbiota

Shanmugam, N. K. N., Trebicka, E., Fu, L.-L., Shi, H. N., & Cherayil, B. J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400278 · Cited by 49 · see citing works

Future perspectives of anemia management in chronic kidney disease using hypoxia-inducible factor-prolyl hydroxylase inhibitors

Sugahara, M., Tanaka, T., & Nangaku, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108272 · Cited by 51 · see citing works

Urinary Growth Differentiation Factor-15 (GDF15) levels as a biomarker of adverse outcomes and biopsy findings in chronic kidney disease

Pérez-Gómez, M. V., Pizarro-Sánchez, M. S., Gracia-Iguacel, C., Cano, S., Cannata‐Ortiz, P., Sánchez-Rodríguez, J. E., Sanz, A. B., Sánchez-Niño, M. D., & Ortíz, A. (2021) · Journal of Nephrology · doi:10.1007/s40620-021-01020-2 · Cited by 49 · see citing works

Hepcidin in hepatocellular carcinoma

Joachim, J. H., & Mehta, K. J. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01753-2 · Cited by 48 · see citing works

HIF stabilizers in the management of renal anemia: from bench to bedside to pediatrics

Kular, D., & Macdougall, I. C. (2018) · Pediatric Nephrology · doi:10.1007/s00467-017-3849-3 · Cited by 46 · see citing works

Acute exercise in elite rugby players increases the circulating level of the cardiovascular biomarker GDF-15

Galliera, E., Lombardi, G., Marazzi, M. G., Grasso, D., Vianello, E., Pozzoni, R., Banfi, G., & Romanelli, M. M. C. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.905697 · Cited by 45 · see citing works

Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes

Urrutia, A. A., Afzal, A., Nelson, J., Davidoff, O., Gross, K. W., & Haase, V. H. (2016) · Blood · doi:10.1182/blood-2016-05-713545 · Cited by 44 · see citing works

Cystathionine β‐synthase is required for body iron homeostasis

Zhou, Y., Wu, X., Zhou, G., Mu, M., Zhang, F., Li, F., Qian, C., Du, F., Yung, W., Qian, Z., et al. (2017) · Hepatology · doi:10.1002/hep.29499 · Cited by 44 · see citing works

Roxadustat in the treatment of anaemia in chronic kidney disease

Vecchio, L. D., & Locatelli, F. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1417386 · Cited by 43 · see citing works

The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia

Landau, D., London, L., Bandach, I., & Segev, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196684 · Cited by 43 · see citing works

Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats

Theurl, M., Nairz, M., Schroll, A., Sonnweber, T., Asshoff, M., Haschka, D., Seifert, M., Willenbacher, W., Wilflingseder, D., Posch, W., et al. (2014) · Haematologica · doi:10.3324/haematol.2013.099481 · Cited by 42 · see citing works

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors and Iron Metabolism

Ogawa, C., Tsuchiya, K., & Maeda, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24033037 · Cited by 43 · see citing works

Balance of cardiac and systemic hepcidin and its role in heart physiology and pathology

Vela, D. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.111 · Cited by 41 · see citing works

Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron

Bailey, P. S. J., & Nathan, J. A. (2018) · Biomedicines · doi:10.3390/biomedicines6020060 · Cited by 41 · see citing works

Hepcidin as a therapeutic target for anemia and inflammation associated with chronic kidney disease

Małyszko, J., Małyszko, J. S., & Matuszkiewicz‐Rowińska, J. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1599358 · Cited by 39 · see citing works

Hypoxia-Inducible Factor–Prolyl Hydroxyl Domain Inhibitors: From Theoretical Superiority to Clinical Noninferiority Compared with Current ESAs?

Locatelli, F., & Vecchio, L. D. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2022040413 · Cited by 40 · see citing works

Potential biomarkers of tissue hypoxia during acute hemodilutional anemia in cardiac surgery: A prospective study to assess tissue hypoxia as a mechanism of organ injury

Hare, G. M. T., Han, K., Leshchyshyn, Y., Mistry, N., Kei, T., Dai, S. Y., Tsui, A. K. Y., Pirani, R. A., Honavar, J., Patel, R. P., et al. (2018) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-018-1140-0 · Cited by 39 · see citing works

Investigational hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) for the treatment of anemia associated with chronic kidney disease

Vecchio, L. D., & Locatelli, F. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1493455 · Cited by 38 · see citing works

Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice

Coffey, R., Jung, G., Olivera, J. D., Karin, G., Pereira, R. C., Nemeth, E., & Ganz, T. (2021) · Blood · doi:10.1182/blood.2021014054 · Cited by 37 · see citing works

Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation

da Silva, I. P., Rausch, V., Peccerella, T., Millonig, G., Seitz, H. K., & Mueller, S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.02.005 · Cited by 35 · see citing works

Drugs activating hypoxia-inducible factors correct erythropoiesis and hepcidin levels via renal EPO induction in mice

Nakai, T., Iwamura, Y., Kato, K., Hirano, I., Matsumoto, Y., Tomioka, Y., Yamamoto, M. P., & Suzuki, N. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023009798 · Cited by 25 · see citing works

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

Mastrogiannaki, M., Matak, P., Mathieu, J. R. R., Delga, S., Mayeux, P., Vaulont, S., & Peyssonnaux, C. (2011) · Haematologica · doi:10.3324/haematol.2011.056119 · Cited by 161 · see citing works

Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly

Gammella, E., Diaz, V., Recalcati, S., Buratti, P., Samaja, M., Dey, S., Noguchi, C. T., Gassmann, M., & Cairo, G. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00410.2014 · Cited by 59 · see citing works

Hypoxia-Dependent Hepcidin Down-Regulation: In Vitro and In Vivo Studies

Ravasi, G. (2016) · BOA (University of Milano-Bicocca)

A direct effect of erythropoietin on hepcidin expression involving EPOR signaling

Pinto, J. P., Ribeiro, S., Pontes, H., Thowfeequ, S., Tosh, D., Carvalho, F. D., & Porto, G. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.1191.9