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Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
Open accessAbstract
The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling. Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.
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“Endocannabinoids generally up-regulate the expression of genes involved in lipid synthesis, such as PPAR transcription factors”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [92]
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Self-citation
Metadata
- Authors
- Oláh, A., Tóth, B. I., Borbíró, I., Sugawara, K., Szöllõsi, A. G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C. C., Paus, R., & Bíró, T.
- Affiliations
- University of Debrecen (HU)
- Osaka City University (JP)
- University of Lübeck (DE)
- San Gallicano Hospital (IT)
- KU Leuven (BE)
- Städtisches Klinikum Dessau (DE)
- University of Manchester (GB)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2014-07-25
- Volume
- 124
- Issue
- 9
- Pages
- 3713-3724
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4151231
- OpenAlex
- W2096513953
- Cited by
- 268
- References
- 79
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 27 · 2023: 33 · 2022: 32 · 2021: 34 · 2020: 31 · 2019: 20 · 2018: 19 · 2017: 15 · 2016: 12 · 2015: 6 · 2014: 4
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- Funders
- Australian Government
- European Commission (FP7-REGPOT-2008-1, 330489, 229920, IUAP P7/13)
- Ministero della Salute (RF 2010)
- Hungarian Scientific Research Fund (101761, 105369)
- KU Leuven (P7/13)
- Vlaamse regering
- FP7 Research Potential of Convergence Regions (2008-1)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- cannabidiol, sebocytes, lipogenesis, TRPV4, MAPK/ERK pathway, NRIP1, adenosine A2A receptor, TRIB3, NF-κB signaling, endocannabinoid system, acne, arachidonic acid, linoleic acid, testosterone
- MeSH terms
- Acne Vulgaris, Anti-Inflammatory Agents, Cannabidiol, Humans, Sebaceous Glands, Sebum, Extracellular Signal-Regulated MAP Kinases, Lipogenesis, TRPV Cation Channels
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