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PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane
Open accessAbstract
PDZ domains have recently emerged as central organizers of protein complexes at the plasma membrane. Although new information about PDZ domains appears at a bewildering rate, we will attempt to distill a few general concepts that have emerged about their biology. These include the structural basis for specificity of their binding interactions and ideas about how they organize both small local protein complexes used for signal transduction (transducisomes) and larger two-dimensional complexes like cell junctions and plasma membrane domains.
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Cites
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., & Cantley, L. C. (1997) · Science · doi:10.1126/science.275.5296.73 · Cited by 1,385
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Electrolyte transport in the mammalian colon: mechanisms and implications for disease
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Verhey, K. J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B. J., Rapoport, T. A., & Margolis, B. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.5.959 · Cited by 609
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Metadata
- Authors
- Fanning, A. S., & Anderson, J. M.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-03-15
- Volume
- 103
- Issue
- 6
- Pages
- 767-772
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1976609927
- Cited by
- 468
- References
- 1
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fanning, A. S., & Anderson, J. M. (1999). PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. Journal of Clinical Investigation. https://doi.org/10.1172/jci6509
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
