The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Superior T memory stem cell persistence supports long-lived T cell memory
Open accessAbstract
Long-lived memory T cells are able to persist in the host in the absence of antigen; however, the mechanism by which they are maintained is not well understood. Recently, a subset of human T cells, stem cell memory T cells (TSCM cells), was shown to be self-renewing and multipotent, thereby providing a potential reservoir for T cell memory throughout life. However, their in vivo dynamics and homeostasis still remain to be defined due to the lack of suitable animal models. We identified T cells with a TSCM phenotype and stem cell-like properties in nonhuman primates. These cells were the least-differentiated memory subset, were functionally distinct from conventional memory cells, and served as precursors of central memory. Antigen-specific TSCM cells preferentially localized to LNs and were virtually absent from mucosal surfaces. They were generated in the acute phase of viral infection, preferentially survived in comparison with all other memory cells following elimination of antigen, and stably persisted for the long term. Thus, one mechanism for maintenance of long-term T cell memory derives from the unique homeostatic properties of TSCM cells. Vaccination strategies designed to elicit durable cellular immunity should target the generation of TSCM cells.
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Cites
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974 · cited 4×
“However, this concept was recently challenged by the discovery of an earlier stage of memory T cell differentiation in humans, termed T stem cell memory (T SCM ) (8).”
BackgroundInfluentialSelf-citationHomeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193
Seventeen-colour flow cytometry: unravelling the immune system
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Self-citationDuration of antiviral immunity after smallpox vaccination
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Host-reactive CD8+ memory stem cells in graft-versus-host disease
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Cited by
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897
Self-citationThe who's who of T ‐cell differentiation: Human memory T ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817
Self-citationHIV-1 persistence in CD4+ T cells with stem cell–like properties
Buzon, M. J., Sun, H., Li, C., Shaw, A., Seiss, K., Ouyang, Z., Martin-Gayo, E., Leng, J., Henrich, T. J., Li, J. Z., et al. (2014) · Nature Medicine · doi:10.1038/nm.3445 · Cited by 414
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans
Galletti, G., De Simone, G., Mazza, E. M. C., Puccio, S., Mezzanotte, C., Bi, T. M., Davydov, A. N., Metsger, M., Scamardella, E., Alvisi, G., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0791-5 · Cited by 299
Self-citationBrummelman, J., Mazza, E. M. C., Alvisi, G., Colombo, F. S., Grilli, A., Mikulak, J., Mavilio, D., Alloisio, M., Ferrari, F., Lopci, E., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180684 · Cited by 334
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Metadata
- Authors
- Lugli, E., Dominguez, M. H., Gattinoni, L., Chattopadhyay, P. K., Bolton, D. L., Song, K., Klatt, N. R., Brenchley, J. M., Vaccari, M., Gostick, E., Price, D. A., Waldmann, T. A., Restifo, N. P., Franchini, G., & Roederer, M.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-01-02
- Volume
- 123
- Issue
- 2
- Pages
- 594-9
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2090342830
- Cited by
- 302
- References
- 6
- FWCI
- 16.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Lugli, E., Dominguez, M. H., Gattinoni, L., Chattopadhyay, P. K., Bolton, D. L., Song, K., Klatt, N. R., Brenchley, J. M., Vaccari, M., Gostick, E., Price, D. A., Waldmann, T. A., Restifo, N. P., Franchini, G., & Roederer, M. (2013). Superior T memory stem cell persistence supports long-lived T cell memory. Journal of Clinical Investigation. https://doi.org/10.1172/jci66327
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