Human memory T cells: generation, compartmentalization and homeostasis
Open accessAbstract
Memory T cells constitute the most abundant lymphocyte population in the body for the majority of a person's lifetime; however, our understanding of memory T cell generation, function and maintenance mainly derives from mouse studies, which cannot recapitulate the exposure to multiple pathogens that occurs over many decades in humans. In this Review, we discuss studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites. We also review how the function and the adaptability of human memory T cells depend on spatial and temporal compartmentalization.
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Memory B and T cells can be rapidly reactivated upon exposure, resulting in enhanced control of initial viral replication and limiting viral dissemination.
“In such cases, memory B and T cells can be rapidly reactivated, resulting in the enhanced control of initial viral replication and limiting viral dissemination in the host (24, 25).”
From mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern (2021) · cites this paper as [25]
Resident memory T cells seed tissues in childhood and persist throughout adulthood.
“Seeding into tissues occurs in childhood, and the resident population persists throughout adulthood”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Farber et al., 2014
Resident memory T cells in lungs, skin, and submucosal sites account for a large fraction of memory cells, numbering more than 5×10^10 cells per person.
“Resident memory T cells in lungs, skin, and submucosal sites account for a large fraction of memory cells numbering more than 5 × 1010 cells in an individual.”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Farber et al., 2014
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · see citing works
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067 · see citing works
Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science · doi:10.1126/science.1198704 · Cited by 2,279 · see citing works
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974 · see citing works
Self-citationPreferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · see citing works
Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
Murali‐Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J. E., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80470-7 · Cited by 1,918 · see citing works
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Chomont, N., Far, M. E., Ancuța, P., Trautmann, L., Procopio, F. A., Yassine‐Diab, B., Boucher, G., Boulassel, M., Ghattas, G., Brenchley, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1972 · Cited by 1,708 · see citing works
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598 · see citing works
Wucherpfennig, K. W., & Strominger, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90348-8 · Cited by 1,545 · see citing works
T-cell quality in memory and protection: implications for vaccine design
Seder, R. A., Darrah, P. A., & Roederer, M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2274 · Cited by 1,541 · see citing works
Khader, S. A., Bell, G. K., Pearl, J. E., Fountain, J. J., Rangel‐Moreno, J., Cilley, G. E., Shen, F., Eaton, S. M., Gaffen, S. L., Swain, S. L., et al. (2007) · Nature Immunology · doi:10.1038/ni1449 · Cited by 1,442 · see citing works
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193 · see citing works
Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157 · see citing works
Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells
Robins, H. S., Campregher, P. V., Srivastava, S. K., Wacher, A., Turtle, C. J., Kahsai, O., Riddell, S. R., Warren, E. H., & Carlson, C. S. (2009) · Blood · doi:10.1182/blood-2009-04-217604 · Cited by 1,122 · see citing works
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1767 · Cited by 1,079 · see citing works
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
Eyerich, S., Eyerich, K., Pennino, D., Carbone, T., Nasorri, F., Pallotta, S., Cianfarani, F., Odorisio, T., Traidl-Hoffmann, C., Behrendt, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40202 · Cited by 1,052 · see citing works
Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026 · see citing works
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002 · see citing works
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K. A., Shoemaker, R. S., Swanson, T., et al. (2011) · Nature · doi:10.1038/nature10003 · Cited by 989 · see citing works
Wilkinson, T. M., Li, C. K. F., Chui, C. S. C., Huang, A. K. Y., Perkins, M., Liebner, J. C., Lambkin-Williams, R., Gilbert, A., Oxford, J., Nicholas, B., et al. (2012) · Nature Medicine · doi:10.1038/nm.2612 · Cited by 974 · see citing works
Duration of antiviral immunity after smallpox vaccination
Hammarlund, E., Lewis, M. W., Hansen, S. G., Strelow, L. I., Nelson, J. A., Sexton, G. J., Hanifin, J. M., & Slifka, M. K. (2003) · Nature Medicine · doi:10.1038/nm917 · Cited by 946 · see citing works
Sanders, M. E., Makgoba, M. W., Sharrow, S. O., Stephany, D., Springer, T. A., Young, H. A., & Shaw, S. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.5.1401 · Cited by 906 · see citing works
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity
Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 883 · see citing works
Memory CD8 T-Cell Differentiation during Viral Infection
Wherry, E. J., & Ahmed, R. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5535-5545.2004 · Cited by 858 · see citing works
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.09.020 · Cited by 848 · see citing works
Self-citationAsymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
Chang, J. T., Palanivel, V., Kinjyo, I., Schambach, F., Intlekofer, A. M., Banerjee, A., Longworth, S. A., Vinup, K. E., Mrass, P., Oliaro, J., et al. (2007) · Science · doi:10.1126/science.1139393 · Cited by 845 · see citing works
Memory T Cell Subsets, Migration Patterns, and Tissue Residence
Mueller, S. N., Gebhardt, T., Carbone, F., & Heath, W. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095954 · Cited by 842 · see citing works
Understanding immunosenescence to improve responses to vaccines
Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827 · see citing works
CCL27–CCR10 interactions regulate T cell–mediated skin inflammation
Homey, B., Alenius, H. T., Müller, A., Soto, H., Bowman, E. P., Yuan, W., McEvoy, L. M., Lauerma, A., Assmann, T., Bünemann, E., et al. (2002) · Nature Medicine · doi:10.1038/nm0202-157 · Cited by 807 · see citing works
The Vast Majority of CLA+ T Cells Are Resident in Normal Skin
Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K.-I., Dowgiert, R. K., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4431 · Cited by 796 · see citing works
Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor
Cosmi, L., Palma, R. D., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., Rodolico, G., Querci, V., Abbate, G., Angeli, R., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080397 · Cited by 708 · see citing works
A vaccine strategy that protects against genital herpes by establishing local memory T cells
Shin, H., & Iwasaki, A. (2012) · Nature · doi:10.1038/nature11522 · Cited by 647 · see citing works
Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A. E., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K. A., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200402 · Cited by 642 · see citing works
Teijaro, J. R., Turner, D., Pham, Q., Wherry, E. J., Lefrançois, L., & Farber, D. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102243 · Cited by 641 · see citing works
Mackay, L. K., Stock, A. T., Ma, J., Jones, C. M., Kent, S., Mueller, S. N., Heath, W., Carbone, F., & Gebhardt, T. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1202288109 · Cited by 638 · see citing works
Kunkel, E. J., Campbell, J. J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A. I., Ebert, E. C., Vierra, M. A., Goodman, S. B., Genovese, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.761 · Cited by 637 · see citing works
From Vaccines to Memory and Back
Sallusto, F., Lanzavecchia, A., Araki, K., & Ahmed, R. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.008 · Cited by 631 · see citing works
Dynamic T cell migration program provides resident memory within intestinal epithelium
Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20090858 · Cited by 628 · see citing works
Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines
Miller, J. D., van der Most, R. G., Akondy, R. S., Glidewell, J. T., Albott, S., Masopust, D., Murali-Krishna, K., Mahar, P. L., Edupuganti, S., Lalor, S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.020 · Cited by 601 · see citing works
Immune clearance of highly pathogenic SIV infection
Hansen, S. G., Piatak, M., Ventura, A. B., Hughes, C. M., Gilbride, R. M., Ford, J. C., Oswald, K. A., Shoemaker, R. S., Li, Y., Lewis, M. S., et al. (2013) · Nature · doi:10.1038/nature12519 · Cited by 598 · see citing works
Paths to stemness: building the ultimate antitumour T cell
Gattinoni, L., Klebanoff, C. A., & Restifo, N. P. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3322 · Cited by 598 · see citing works
Self-citationWakim, L. M., Davis, A. S. W., & Bevan, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010201107 · Cited by 577 · see citing works
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
den Braber, I., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R., Bregje de Boer, A., Willems, N., Schrijver, E. H. R., Spierenburg, G., Gaiser, K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.006 · Cited by 572 · see citing works
Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.
Altman, J. D., Moss, P. A. H., Goulder, P., Barouch, D. H., McHeyzer‐Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (2011) · PubMed · Cited by 572 · see citing works
Why must T cells be cross-reactive?
Sewell, A. K. (2012) · Nature reviews. Immunology · doi:10.1038/nri3279 · Cited by 544 · see citing works
Anthony, R. M., Urban, J. F., Alem, F., Hamed, H. A., Rozo, C. T., Boucher, J.-L., Van Rooijen, N., & Gause, W. C. (2006) · Nature Medicine · doi:10.1038/nm1451 · Cited by 522 · see citing works
Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.
Smith, S. H., Brown, M. H., Rowe, D., Callard, R. E., & Beverley, P. C. L. (1986) · PubMed Central · Cited by 517 · see citing works
CD8 <sup>+</sup> T‐cell memory in tumor immunology and immunotherapy
Klebanoff, C. A., Gattinoni, L., & Restifo, N. P. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00391.x · Cited by 511 · see citing works
Self-citationA Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers
Tan, L., Gudgeon, N. H., Annels, N. E., Hansasuta, P., O’Callaghan, C. A., Rowland‐Jones, S., McMichael, A. J., Rickinson, A. B., & Callan, M. F. C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1827 · Cited by 499 · see citing works
Progressive differentiation and selection of the fittest in the immune response
Lanzavecchia, A., & Sallusto, F. (2002) · Nature Reviews Immunology · doi:10.1038/nri959 · Cited by 495 · see citing works
Vukmanovic‐Stejic, M., Zhang, Y., Cook, J. E., Fletcher, J. M., McQuaid, A. J., Masters, J. E., Rustin, M. H. A., Taams, L. S., Beverley, P. C. L., Macallan, D. C., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28941 · Cited by 476 · see citing works
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication
Eisele, E., & Siliciano, R. F. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.010 · Cited by 474 · see citing works
Rules of chemokine receptor association with T cell polarization in vivo
Kim, C. H., Rott, L. S., Kunkel, E. J., Genovese, M. C., Andrew, D. P., Wu, L., & Butcher, E. C. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13543 · Cited by 474 · see citing works
No one is naive: the significance of heterologous T-cell immunity
Welsh, R. M., & Selin, L. K. (2002) · Nature reviews. Immunology · doi:10.1038/nri820 · Cited by 465 · see citing works
Cytomegalovirus Vectors Violate CD8 + T Cell Epitope Recognition Paradigms
Hansen, S. G., Sacha, J. B., Hughes, C. M., Ford, J. C., Burwitz, B. J., Scholz, I., Gilbride, R. M., Lewis, M. S., Gilliam, A. N., Ventura, A. B., et al. (2013) · Science · doi:10.1126/science.1237874 · Cited by 433 · see citing works
Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults
Su, L. F., Kidd, B. A., Han, A., Kotzin, J. J., & Davis, M. M. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.021 · Cited by 429 · see citing works
Lee, L. Y.-H., Do, L. A. H., Simmons, C. P., de Jong, M. D., Châu, N. V. V., Schumacher, R., Peng, Y. C., McMichael, A. J., Farrar, J., Smith, G. L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32460 · Cited by 423 · see citing works
Human naive and memory T lymphocytes differ in telomeric length and replicative potential.
Weng, N., Levine, B. L., June, C. H., & Hodes, R. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11091 · Cited by 418 · see citing works
Disparate Individual Fates Compose Robust CD8 + T Cell Immunity
Buchholz, V. R., Floßdorf, M., Hensel, I., Kretschmer, L., Weißbrich, B., Gräf, P., Verschoor, A., Schiemann, M., Höfer, T., & Busch, D. H. (2013) · Science · doi:10.1126/science.1235454 · Cited by 406 · see citing works
Lung niches for the generation and maintenance of tissue-resident memory T cells
Turner, D., Bickham, K. L., Thome, J. J. C., Kim, C. Y., D’Ovidio, F., Wherry, E. J., & Färber, D. L. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.67 · Cited by 399 · see citing works
A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets.
Stemberger, C., Huster, K., Koffler, M., Anderl, F., Schiemann, M., Wagner, H., & Busch, D. (2007) · Immunity · doi:10.1016/j.immuni.2007.10.012 · Cited by 394 · see citing works
Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses
Hand, T. W., dos Santos, L. M., Bouladoux, N. J., Molloy, M. J., Pagán, A. J., Pepper, M., Maynard, C. L., Elson, C. O., & Belkaid, Y. (2012) · Science · doi:10.1126/science.1220961 · Cited by 393 · see citing works
Overlap and Effective Size of the Human CD8 + T Cell Receptor Repertoire
Robins, H. S., Srivastava, S. K., Campregher, P. V., Turtle, C. J., Andriesen, J. G., Riddell, S. R., Carlson, C. S., & Warren, E. H. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001442 · Cited by 383 · see citing works
Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo
Klonowski, K. D., Williams, K., Marzo, A. L., Blair, D. A., Lingenheld, E. G., & Lefrançois, L. (2004) · Immunity · doi:10.1016/s1074-7613(04)00103-7 · Cited by 383 · see citing works
Host-reactive CD8+ memory stem cells in graft-versus-host disease
Zhang, Y., Joe, G., Hexner, E., Zhu, J., & Emerson, S. G. (2005) · Nature Medicine · doi:10.1038/nm1326 · Cited by 369 · see citing works
Saule, P., Trauet, J., Dutriez, V., Lekeux, V., Dessaint, J., & Labalette, M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.11.001 · Cited by 369 · see citing works
Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6
SINGH, S. P., Zhang, H. H., Foley, J. F., Hedrick, M. N., & Farber, J. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.214 · Cited by 367 · see citing works
Clark, R. A., Watanabe, R., Teague, J. E., Schlapbach, C., Tawa, M. C., Adams, N., Dorosario, A. A., Chaney, K. S., Cutler, C. S., LeBoeuf, N. R., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003008 · Cited by 367 · see citing works
Heterogeneous Differentiation Patterns of Individual CD8 + T Cells
Gerlach, C., Rohr, J., Perié, L., van Rooij, N., van Heijst, J. W. J., Velds, A., Urbanus, J. H. M., Naik, S. H., Jacobs, H., Beltman, J. B., et al. (2013) · Science · doi:10.1126/science.1235487 · Cited by 361 · see citing works
Cutting Edge: Gut Microenvironment Promotes Differentiation of a Unique Memory CD8 T Cell Population
Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L., & Ahmed, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2079 · Cited by 357 · see citing works
Professional Memory CD4+ T Lymphocytes Preferentially Reside and Rest in the Bone Marrow
Tokoyoda, K., Zehentmeier, S., Hegazy, A. N., Albrecht, I., Grün, J. R., Löhning, M., & Radbruch, A. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.015 · Cited by 352 · see citing works
McFall‐Ngai, M. (2007) · Nature · doi:10.1038/445153a · Cited by 345 · see citing works
Zhu, J., Koelle, D. M., Cao, J., Vazquez, J., Huang, M. L., Hladik, F., Wald, A., & Corey, L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061792 · Cited by 344 · see citing works
CCR7 Expression and Memory T Cell Diversity in Humans
Campbell, J. J., Murphy, K. E., Kunkel, E. J., Brightling, C. E., Soler, D., Shen, Z., Boisvert, J., Greenberg, H. B., Vierra, M. A., Goodman, S. B., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.877 · Cited by 335 · see citing works
Chemokines in the systemic organization of immunity
Campbell, D. J., Kim, C. H., & Butcher, E. C. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00067.x · Cited by 330 · see citing works
He, X.-S., Holmes, T. H., Zhang, C., Mahmood, K., Kemble, G. W., Lewis, D. B., Dekker, C. L., Greenberg, H. B., & Arvin, A. M. (2006) · Journal of Virology · doi:10.1128/jvi.01460-06 · Cited by 322 · see citing works
Superior T memory stem cell persistence supports long-lived T cell memory.
Lugli, E., Dominguez, M., Gattinoni, L., Chattopadhyay, P. K., Bolton, D., Song, K.-M., Klatt, N., Brenchley, J., Vaccari, M., Gostick, E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66327 · Cited by 321 · see citing works
Self-citationIntravascular staining redefines lung CD8 T cell responses
Anderson, K., Sung, H., Skon, C. N., Lefrançois, L., Deisinger, A., Vezys, V., & Masopust, D. (2012) · Journal of Immunology · doi:10.4049/jimmunol.1201682 · Cited by 309 · see citing works
Skin-resident T cells: the ups and downs of on site immunity
Clark, R. A. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.247 · Cited by 298 · see citing works
Newell, E. W., Sigal, N., Nair, N., Kidd, B. A., Greenberg, H. B., & Davis, M. M. (2013) · Nature Biotechnology · doi:10.1038/nbt.2593 · Cited by 295 · see citing works
Weng, N.-P., Araki, Y., & Subedi, K. (2012) · Nature Reviews Immunology · doi:10.1038/nri3173 · Cited by 290 · see citing works
Purwar, R., Campbell, J. J., Murphy, G. F., Richards, W. G., Clark, R. A., & Kupper, T. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016245 · Cited by 286 · see citing works
Siegel, A., Heimall, J., Freeman, A., Hsu, A. P., Brittain, E., Brenchley, J., Douek, D., Fahle, G., Cohen, J. I., Holland, S., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.016 · Cited by 277 · see citing works
Burrows, S. R., Khanna, R., Burrows, J. M., & Moss, D. J. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1155 · Cited by 271 · see citing works
Mature CD8+ T lymphocyte response to viral infection during fetal life
Marchant, A., Appay, V., van der Sande, M. A. B., Dulphy, N., Liesnard, C., Kidd, M., Kaye, S., Ojuola, O. O., Gillespie, G. M. A., Cuero, A. L. V., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17470 · Cited by 269 · see citing works
Duchmann, R., May, E., Heike, M., Knolle, P. A., Neurath, M. F., & BÜSCHENFELDE, K.-H. M. Z. (1999) · Gut · doi:10.1136/gut.44.6.812 · Cited by 258 · see citing works
Cossarizza, A., Ortolani, C., Paganelli, R., Barbieri, D., Monti, D., Sansoni, P., Fagiolo, U., Castellani, G., Bersani, F., Londei, M., et al. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01691-0 · Cited by 253 · see citing works
Liu, L., Zhong, Q., Tian, T., Dubin, K. A., Athale, S., & Kupper, T. S. (2010) · Nature Medicine · doi:10.1038/nm.2078 · Cited by 252 · see citing works
Quantifying T lymphocyte turnover
de Boer, R. J., & Perelson, A. S. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.12.025 · Cited by 241 · see citing works
Mature CD8+ T lymphocyte response to viral infection during fetal life
Marchant, A., Appay, V., van der Sande, M. A. B., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317470 · Cited by 229 · see citing works
Amyes, E., Hatton, C., Montamat‐Sicotte, D., Gudgeon, N. H., Rickinson, A. B., McMichael, A. J., & Callan, M. F. C. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022058 · Cited by 225 · see citing works
Infectious Disease Hospitalizations in the United States
Christensen, K. L. Y., Holman, R. C., Steiner, C., Sejvar, J. J., Stoll, B. J., & Schonberger, L. B. (2009) · Clinical Infectious Diseases · doi:10.1086/605562 · Cited by 220 · see citing works
The precursors of memory: models and controversies
Ahmed, R., Bevan, M. J., Reiner, S. L., & Fearon, D. T. (2009) · Nature reviews. Immunology · doi:10.1038/nri2619 · Cited by 202 · see citing works
Andrew, D. P., Ruffing, N., Kim, C. H., Miao, W., Heath, H., Li, Y., Murphy, K. E., Campbell, J. J., Butcher, E. C., & Wu, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.103 · Cited by 198 · see citing works
A Novel Method for the Isolation of Skin Resident T Cells from Normal and Diseased Human Skin
Clark, R. A., Chong, B. F., Mirchandani, N., Yamanaka, K.-I., Murphy, G. F., Dowgiert, R. K., & Kupper, T. S. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700199 · Cited by 197 · see citing works
Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans
Macallan, D. C., Wallace, D. L., Zhang, Y., de Lara, C., Worth, A. T., Ghattas, H., Griffin, G. E., Beverley, P. C. L., & Tough, D. F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040341 · Cited by 193 · see citing works
Teijaro, J. R., Verhoeven, D. E., Page, C., Turner, D., & Färber, D. L. (2010) · Journal of Virology · doi:10.1128/jvi.01069-10 · Cited by 191 · see citing works
The T-Cell Response to HIVPreprint
Walker, B. D., & McMichael, A. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007054 · Cited by 188 · see citing works
Piet, B., de Bree, G. J., Smids-Dierdorp, B. S., van der Loos, C. M., Remmerswaal, E. B. M., von der Thüsen, J. H., van Haarst, J. M. W., Eerenberg, J. P., ten Brinke, A., van der Bij, W., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44675 · Cited by 183 · see citing works
Impairment of immunological memory in the absence of MHC despite survival of memory T cells
Kassiotis, G., Garcia, S., Simpson, E., & Stockinger, B. (2002) · Nature Immunology · doi:10.1038/ni766 · Cited by 182 · see citing works
de Bree, G. J., van Leeuwen, E. M. M., Out, T. A., Jansen, H. M., Jonkers, R. E., & van Lier, R. A. W. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051365 · Cited by 177 · see citing works
Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy
Gattinoni, L., Ji, Y., & Restifo, N. P. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0356 · Cited by 175 · see citing works
Self-citationClute, S. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25078 · Cited by 170 · see citing works
T-cell recruitment to the intestinal mucosa
Agace, W. W. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.08.003 · Cited by 163 · see citing works
Hidden memories: Front line memory T cells and early pathogen interception
Masopust, D., & Picker, L. (2012) · Journal of Immunology · doi:10.4049/jimmunol.1102695 · Cited by 163 · see citing works
CD8+ T-cell selection, function, and death in the primary immune response in vivo
Callan, M. F. C., Fazou, C., Yang, H., Rostron, T., Poon, K., Hatton, C., & McMichael, A. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10590 · Cited by 158 · see citing works
Stunz, L. L., Lenert, P. S., Peckham, D., Yi, A., Haxhinasto, S. A., Chang, M., Krieg, A. Μ., & Ashman, R. F. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200205)32:5 · Cited by 150 · see citing works
Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract
Ruane, D., Brane, L., Reis, B. S., Cheong, C., Poles, J., Do, Y., Zhu, H., Velinzon, K., Choi, J., Studt, N., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122762 · Cited by 141 · see citing works
González, P. A., Prado, C. E., Leiva, E., Carreño, L. J., Bueno, S. M., Riedel, C. A., & Kalergis, A. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802555105 · Cited by 140 · see citing works
Healthy Human Subjects Have CD4+ T Cells Directed against H5N1 Influenza Virus
Roti, M., Yang, J., Berger, D., Huston, L., James, E. A., & Kwok, W. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1758 · Cited by 130 · see citing works
Measurement and modeling of human T cell kinetics
Macallan, D. C., Asquith, B., Irvine, A. J., Wallace, D. L., Worth, A. T., Ghattas, H., Zhang, Y., Griffin, G. E., Tough, D. F., & Beverley, P. C. L. (2003) · European Journal of Immunology · doi:10.1002/eji.200323763 · Cited by 129 · see citing works
Natural Reinfection with Respiratory Syncytial Virus Does Not Boost Virus-Specific T-Cell Immunity
Bont, L., Versteegh, J., Swelsen, W. T. N., Heijnen, C. J., Kavelaars, A., Brus, F., Draaisma, J. M. T., Pekelharing‐Berghuis, M., van Diemen–Steenvoorde, R. A. A. M., & Kimpen, J. L. L. (2002) · Pediatric Research · doi:10.1203/00006450-200209000-00009 · Cited by 114 · see citing works
Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040178 · Cited by 111 · see citing works
Edele, F., Molenaar, R., Gütle, D., Dudda, J. C., Jakob, T., Homey, B., Mebius, R. E., Hornef, M. W., & Martin, S. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3745 · Cited by 106 · see citing works
Herndler-Brandstetter, D., Landgraf, K., Jenewein, B., Tzankov, A., Brunauer, R., Brunner, S., Parson, W., Kloss, F., Gassner, R., Lepperdinger, G., et al. (2011) · Journal of Immunology · doi:10.4049/jimmunol.1100243 · Cited by 106 · see citing works
Local immunity by tissue-resident CD8+ memory T cells
Gebhardt, T., & Mackay, L. K. (2012) · Front. Immun. · doi:10.3389/fimmu.2012.00340 · Cited by 103 · see citing works
Jaimes, M. C., Rojas, O. L., González, A., Cajiao, I., Charpilienne, A., Pothier, P., Kohli, É., Greenberg, H. B., Franco, M. A., & Ángel, J. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.4741-4749.2002 · Cited by 94 · see citing works
Wan, Q., Kozhaya, L., El-Hed, A., Ramesh, R., Carlson, T. J., Djuretic, I. M., Sundrud, M. S., & Unutmaz, D. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102516 · Cited by 92 · see citing works
Peripheral tissue surveillance and residency by memory T cells
Gebhardt, T., Mueller, S. N., Heath, W. R., & Carbone, F. R. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.08.008 · Cited by 91 · see citing works
Bunders, M. J., van der Loos, C. M., Klarenbeek, P. L., van Hamme, J. L., Boer, K., Wilde, J. C. H., de Vries, N., van Lier, R. A. W., Kootstra, N. A., Pals, S. T., et al. (2012) · Blood · doi:10.1182/blood-2012-06-437566 · Cited by 88 · see citing works
Cimbro, R., Vassena, L., Arthos, J. A., Cicala, C., Kehrl, J. H., Park, C., Sereti, I., Lederman, M. M., Fauci, A. S., & Lusso, P. (2012) · Blood · doi:10.1182/blood-2012-06-434779 · Cited by 87 · see citing works
Lumsden, J. M., Schwenk, R., Rein, L., Moris, P., Janssens, M., Ofori‐Anyinam, O., Cohen, J., Kester, K. E., Heppner, D. G., & Krzych, U. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020775 · Cited by 85 · see citing works
Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV
Chomont, N., DaFonseca, S., Vandergeeten, C., Ancuța, P., & Sékaly, R. (2010) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e3283413775 · Cited by 82 · see citing works
T cell receptor crossreactivity as a general property of T cell recognition
WUCHERPFENNIG, K. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.11.003 · Cited by 71 · see citing works
MHC multimer technology: current status and future prospects
Bakker, A., & Schumacher, T. N. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.008 · Cited by 70 · see citing works
Wakim, L., Gebhardt, T., Heath, W., & Carbone, F. (2008) · Journal of Immunology · doi:10.4049/jimmunol.181.9.5837 · Cited by 69 · see citing works
Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells.
Youngblood, B., Wherry, E. J., & Ahmed, R. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32834ddcf2 · Cited by 68 · see citing works
Alloreactivity from human viral specific memory T-cells
D'Orsogna, L. J. A., Roelen, D. L., Doxiadis, I. I. N., & Claas, F. H. J. (2010) · Transplant Immunology · doi:10.1016/j.trim.2010.06.008 · Cited by 64 · see citing works
He, X.-S., Mahmood, K., Maecker, H. T., Holmes, T. H., Kemble, G. W., Arvin, A. M., & Greenberg, H. B. (2003) · The Journal of Infectious Diseases · doi:10.1086/368218 · Cited by 63 · see citing works
Varicella Zoster–Specific CD4+Foxp3+ T Cells Accumulate after Cutaneous Antigen Challenge in Humans
Vukmanovic‐Stejic, M., Sandhu, D., Sobande, T. O., Agius, E., Lacy, K. E., Riddell, N. E., Montez, S., Dintwe, O., Scriba, T. J., Breuer, J., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201331 · Cited by 61 · see citing works
Do most lymphocytes in humans really reside in the gut?
Ganusov, V., & de Boer, R. D. (2007) · Trends in immunology · doi:10.1016/j.it.2007.08.009 · Cited by 60 · see citing works
Wang, A., Chandran, S. S., Shah, S. A., Chiu, Y., Paria, B. C., Aghamolla, T., Alvarez‐Downing, M. M., Lee, C. R., Singh, S., Li, T. Y., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004306 · Cited by 59 · see citing works
Self-citationImmune memory and aging: an infinite or finite resource?
Nikolich-Žugich, J., & Rudd, B. D. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.06.011 · Cited by 58 · see citing works
CD4+ T cells with specific reactivity against astrovirus isolated from normal human small intestine
Molberg, Ø., Nilsen, E. M., Sollid, L. M., Scott, H., Brandtzæg, P., Thorsby, E., & Lundin, K. E. A. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70639-0 · Cited by 57 · see citing works
Zhang, H. H., Song, K., Rabin, R. L., Hill, B. J., Perfetto, S. P., Roederer, M., Douek, D. C., Siegel, R. M., & Farber, J. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904156 · Cited by 52 · see citing works
Hillaire, M. L. B., Trierum, S. E. V.-V., Bodewes, R., van Baalen, C. A., van Binnendijk, R. S., Koopmans, M., Fouchier, R. A. M., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2011) · Journal of Virology · doi:10.1128/jvi.05204-11 · Cited by 52 · see citing works
Immune mechanisms of HIV control
Chakrabarti, L. A., & Simon, V. R. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.06.006 · Cited by 51 · see citing works
Teijaro, J. R., Njau, M. N., Verhoeven, D. E., Chandran, S. S., Nadler, S. G., Hasday, J. D., & Färber, D. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803860 · Cited by 50 · see citing works
Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells
Youngblood, B., Davis, C. W., & Ahmed, R. (2010) · International Immunology · doi:10.1093/intimm/dxq437 · Cited by 47 · see citing works
Zhang, X., Dong, H., Lin, W., Voss, S. G., Hinkley, L., Westergren, M., Tian, G., Berry, D. J., Lewellen, D., Vile, R. G., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.6730 · Cited by 45 · see citing works
de Bree, G. J., Daniels, J. M. A., van Schilfgaarde, M., Jansen, H. M., Out, T. A., van Lier, R. A. W., & Jonkers, R. E. (2007) · The Journal of Infectious Diseases · doi:10.1086/517612 · Cited by 45 · see citing works
Functional Specialization of Memory Th Cells Revealed by Expression of Integrin CD49b
Kassiotis, G., Gray, D., Kiafard, Z., Zwirner, J., & Stockinger, B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.968 · Cited by 45 · see citing works
Komatsu, H., Inui, A., Sogo, T., Fujisawa, T., Nagasaka, H., Nonoyama, S., Sierro, S. R., Northfield, J. W., Lucas, M., Vargas, A., et al. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-11 · Cited by 38 · see citing works
Immunological memory ≠ protective immunity
Zinkernagel, R. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0972-y · Cited by 37 · see citing works
Bushar, N. D., Corbo‐Rodgers, E., Schmidt, M. A., Maltzman, J. S., & Färber, D. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908126107 · Cited by 34 · see citing works
Remakus, S., & Sigal, L. J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6217-0_9 · Cited by 33 · see citing works
Old and New: Recent Innovations in Vaccine Biology and Skin T Cells
Kupper, T. S. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.400 · Cited by 32 · see citing works
de Waal, L., Koopman, L. P., van Benten, I. J., Brandenburg, A. H., Mulder, P. G. H., de Swart, R. L., Fokkens, W. J., Neijens, H. J., & Osterhaus, A. D. M. E. (2003) · Journal of Medical Virology · doi:10.1002/jmv.10396 · Cited by 30 · see citing works
The rationale for the IL‐2‐independent generation of the self‐renewing central memory CD8+ T cells
Fearon, D. T., Carr, J. M., Telaranta, A. I., Carrasco, M. J., & Thaventhiran, J. E. D. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00390.x · Cited by 30 · see citing works
Daubenberger, C., Nickel, B., Ciatto, C., Grütter, M., Pöltl-Frank, F., Rossi, L., Siegler, U., Robinson, J., Kashala, O., Patarroyo, M., et al. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200212)32:12 · Cited by 17 · see citing works
Probing the T-cell receptor repertoire with deep sequencing
Miconnet, I. (2011) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32834ddcae · Cited by 17 · see citing works
Immune cell profile in infants’ lung tissue
Santos, A. B. G., Binoki, D. H., da Silva, L. F. F., Araujo, B., den Otter, I., Annoni, R., Tsokos, M., Stein, R. T., Hiemstra, P. S., Rabe, K. F., et al. (2013) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2013.05.003 · Cited by 14 · see citing works
Pédron, B., Guérin, V., Cordeiro, D. J., Masmoudi, S., Dalle, J., & Sterkers, G. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e318204e469 · Cited by 11 · see citing works
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Mechanisms of resistance to immune checkpoint inhibitors
Jenkins, R. W., Barbie, D. A., & Flaherty, K. T. (2018) · British Journal of Cancer · doi:10.1038/bjc.2017.434 · Cited by 1,383 · see citing works
Immunosenescence: molecular mechanisms and diseases
Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,023 · see citing works
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
Goel, R. R., Painter, M. M., Apostolidis, S. A., Mathew, D., Meng, W., Rosenfeld, A. M., Lundgreen, K. A., Reynaldi, A., Khoury, D. S., Pattekar, A., et al. (2021) · Science · doi:10.1126/science.abm0829 · Cited by 873 · see citing works
Therapeutic T cell engineering
Sadelain, M., Rivière, I., & Riddell, S. R. (2017) · Nature · doi:10.1038/nature22395 · Cited by 886 · see citing works
Szabo, P. A., Levitin, H. M., Miron, M., Snyder, M. E., Senda, T., Yuan, J., Cheng, Y. L., Bush, E. C., Dogra, P., Thapa, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12464-3 · Cited by 756 · see citing works
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance
Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. (2015) · Cell · doi:10.1016/j.cell.2015.03.031 · Cited by 685 · see citing works
Fares, C. M., Allen, E. M. V., Drake, C. G., Allison, J. P., & Hu‐Lieskovan, S. (2019) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_240837 · Cited by 648 · see citing works
T memory stem cells in health and disease
Gattinoni, L., Speiser, D. E., Lichterfeld, M. D., & Bonini, C. (2017) · Nature Medicine · doi:10.1038/nm.4241 · Cited by 619 · see citing works
Spatial map of human T cell compartmentalization and maintenance over decades of life
Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587 · see citing works
Self-citationResistance to PD1/PDL1 checkpoint inhibition
O’Donnell, J. S., Long, G. V., Scolyer, R. A., Teng, M. W. L., & Smyth, M. J. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.11.007 · Cited by 573 · see citing works
Lee, J., Zhang, T., Hwang, I., Kim, A., Nitschke, L., Kim, M. J., Scott, J. M., Kamimura, Y., Lanier, L. L., & Kim, S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.013 · Cited by 554 · see citing works
Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Kishton, R. J., Sukumar, M., & Restifo, N. P. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.016 · Cited by 548 · see citing works
Self-citationEmerging insights into natural killer cells in human peripheral tissues
Björkström, N. K., Ljunggren, H., & Michaëlsson, J. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.34 · Cited by 451 · see citing works
A safe and potent anti-CD19 CAR T cell therapy
Ying, Z., Huang, X. F., Xiang, X., Liu, Y., Kang, X., Song, Y., Guo, X., Liu, H., Ding, N., Zhang, T., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0421-7 · Cited by 441 · see citing works
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer
Cafri, G., Gartner, J. J., Zaks, T., Hopson, K., Levin, N., Paria, B. C., Parkhurst, M. R., Yossef, R., Lowery, F. J., Jafferji, M. S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134915 · Cited by 427 · see citing works
Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362 · see citing works
Ontogeny of early life immunity
Dowling, D. J., & Levy, O. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.007 · Cited by 365 · see citing works
Rosenblum, M. D., Way, S. S., & Abbas, A. K. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.1 · Cited by 345 · see citing works
Heterogeneity of Human CD4 <sup>+</sup> T Cells Against Microbes
Sallusto, F. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112056 · Cited by 336 · see citing works
Hegazy, A. N., West, N. R., Stubbington, M. J. T., Wendt, E., Suijker, K. I. M., Datsi, A., This, S., Danne, C., Campion, S., Duncan, S. H., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.047 · Cited by 338 · see citing works
Targeting the Latent Reservoir for HIV-1
Sengupta, S., & Siliciano, R. F. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.030 · Cited by 333 · see citing works
Brummelman, J., Mazza, E. M. C., Alvisi, G., Colombo, F. S., Grilli, A., Mikulak, J., Mavilio, D., Alloisio, M., Ferrari, F., Lopci, E., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180684 · Cited by 334 · see citing works
Memory T cells: strategies for optimizing tumor immunotherapy
Liu, Q., Sun, Z., & Chen, L. (2020) · Protein & Cell · doi:10.1007/s13238-020-00707-9 · Cited by 332 · see citing works
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy
Basu, A. B., Ramamoorthi, G., Albert, G. K., Gallen, C., Beyer, A., Snyder, C., Koski, G. K., Disis, M. L., Czerniecki, B. J., & Kodumudi, K. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669474 · Cited by 318 · see citing works
CAR-T cell manufacturing: Major process parameters and next-generation strategies
Ceja, M. A., Khericha, M., Harris, C., Puig-Saus, C., & Chen, Y. (2024) · Journal of Experimental Medicine · doi:10.1084/jem.20230903 · Cited by 293 · see citing works
Thome, J. J. C., Bickham, K. L., Ohmura, Y., Kubota, M., Matsuoka, N., Gordon, C., Granot, T., Griesemer, A., Lerner, H., Kato, T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4008 · Cited by 305 · see citing works
Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08534-1 · Cited by 304 · see citing works
Integrative Physiology of Pneumonia
Quinton, L. J., Walkey, A. J., & Mizgerd, J. P. (2018) · Physiological Reviews · doi:10.1152/physrev.00032.2017 · Cited by 308 · see citing works
Patin, É., Hasan, M., Bergstedt, J., Rouilly, V., Libri, V., Urrutia, A., Alanio, C., Šćepanović, P., Hammer, C., Jönsson, F., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0049-7 · Cited by 301 · see citing works
Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
Loyal, L., Braun, J., Henze, L., Kruse, B., Dingeldey, M., Reimer, U., Kern, F., Schwarz, T., Mangold, M., Unger, C., et al. (2021) · Science · doi:10.1126/science.abh1823 · Cited by 284 · see citing works
Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology
Masopust, D., Sivula, C. P., & Jameson, S. C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700453 · Cited by 296 · see citing works
Enamorado, M., Iborra, S., Priego, E., Cueto, F. J., Quintana, J. A., Martínez-Cano, S., Mejías‐Pérez, E., Estéban, M., Melero, I., Hidalgo, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms16073 · Cited by 295 · see citing works
Developmental plasticity allows outside-in immune responses by resident memory T cells
Fonseca, R., Beura, L. K., Quarnstrom, C. F., Ghoneim, H. E., Fan, Y., Zebley, C. C., Scott, M. C., Fares-Frederickson, N. J., Wijeyesinghe, S., Thompson, E. A., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0607-7 · Cited by 286 · see citing works
Obesity accelerates T cell senescence in murine visceral adipose tissue
Shirakawa, K., Yan, X., Shinmura, K., Endo, J., Kataoka, M., Katsumata, Y., Yamamoto, T., Anzai, A., Isobe, S., Yoshida, N., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88606 · Cited by 271 · see citing works
Angela, M., Endo, Y., Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., Yokote, K., & Nakayama, T. (2016) · Nature Communications · doi:10.1038/ncomms13683 · Cited by 258 · see citing works
Beura, L., Mitchell, J. S., Thompson, E., Schenkel, J., Mohammed, J., Wijeyesinghe, S. P., Fonseca, R., Burbach, B., Hickman, H., Vezys, V., et al. (2018) · Nature Immunology · doi:10.1038/s41590-017-0029-3 · Cited by 248 · see citing works
Palmer, C. D., Rappaport, A., Davis, M. J., Hart, M. G., Scallan, C. D., Hong, S., Gitlin, L., Kraemer, L. D., Kounlavouth, S., Yang, A., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01937-6 · Cited by 249 · see citing works
Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
He, S., Wang, L.-H., Liu, Y., Li, Y., Chen, H.-T., Xu, J.-H., Peng, W., Lin, G.-W., Wei, P.-P., Li, B., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02210-0 · Cited by 234 · see citing works
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity
Wang, D., Aguilar, B., Starr, R., Alizadeh, D., Brito, A., Sarkissian, A., Ostberg, J. R., Forman, S. J., & Brown, C. E. (2018) · JCI Insight · doi:10.1172/jci.insight.99048 · Cited by 233 · see citing works
Age related human T cell subset evolution and senescence
Li, M., Yao, D., Zeng, X., Kasakovski, D., Zhang, Y., Chen, S., Zha, X., Li, Y., & Xu, L. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0165-8 · Cited by 230 · see citing works
Memory CD4+ T Cells in Immunity and Autoimmune Diseases
Raphael, I., Robinson, R. R., & Forsthuber, T. G. (2020) · Cells · doi:10.3390/cells9030531 · Cited by 232 · see citing works
Tissue-resident memory T cells in tumor immunity and immunotherapy
Okła, K., Färber, D. L., & Zou, W. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201605 · Cited by 230 · see citing works
FOXO1 is a master regulator of memory programming in CAR T cells
Doan, A. E., Mueller, K. P., Chen, A. Y., Rouin, G. T., Chen, Y.-S., Daniel, B., Lattin, J., Markovska, M., Mozarsky, B., Arias-Umana, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07300-8 · Cited by 210 · see citing works
Role of memory T cell subsets for adoptive immunotherapy
Busch, D. H., Fräßle, S. P., Sommermeyer, D., Buchholz, V. R., & Riddell, S. R. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.02.001 · Cited by 226 · see citing works
White, K. D., Chung, W., Chung, W., Mallal, S. A., & Phillips, E. J. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.050 · Cited by 224 · see citing works
The Regulation of Inflammation by Innate and Adaptive Lymphocytes
Cronkite, D. A., & Strutt, T. M. (2018) · Journal of Immunology Research · doi:10.1155/2018/1467538 · Cited by 228 · see citing works
Martínez‐Zamudio, R. I., Dewald, H. K., Vasilopoulos, T., Gittens‐Williams, L., Fitzgerald‐Bocarsly, P., & Herbig, U. (2021) · Aging Cell · doi:10.1111/acel.13344 · Cited by 213 · see citing works
Mastelic-Gavillet, B., Rodrigo, B. N., Décombaz, L., Wang, H., Ercolano, G., Ahmed, R., Lozano, L. E., Ianaro, A., Derré, L., Massimo Valerio, A., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0719-5 · Cited by 220 · see citing works
SARS-CoV-2 infection generates tissue-localized immunological memory in humans
Poon, M. M. L., Rybkina, K., Kato, Y., Kubota, M., Matsumoto, R., Bloom, N. I., Zhang, Z., Hastie, K. M., Grifoni, A., Weiskopf, D., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abl9105 · Cited by 214 · see citing works
Memory CD8+ T cell responses to cancer
Han, J., Khatwani, N., Searles, T. G., Turk, M. J., & Angeles, C. V. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101435 · Cited by 219 · see citing works
Understanding HIV Latency: The Road to an HIV Cure
Dahabieh, M. S., Battivelli, E., & Verdin, E. M. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-092112-152941 · Cited by 215 · see citing works
Ma, R., Ji, T., Zhang, Y., Dong, W., Chen, X., Xu, P., Chen, D., Liang, X., Yin, X., Liu, Y., et al. (2017) · Nature Cell Biology · doi:10.1038/s41556-017-0002-2 · Cited by 211 · see citing works
Bioinformatic and Statistical Analysis of Adaptive Immune Repertoires
Greiff, V., Miho, E., Menzel, U., & Reddy, S. T. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.09.006 · Cited by 210 · see citing works
Czarnowicki, T., Esaki, H., Gonzalez, J., Malajian, D., Shemer, A., Noda, S., Talasila, S., Berry, A., Gray, J., Becker, L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.049 · Cited by 210 · see citing works
A guide to adaptive immune memory
Lam, N., Lee, Y. S., & Färber, D. L. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01040-6 · Cited by 217 · see citing works
Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology
Turner, D., & Färber, D. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00331 · Cited by 198 · see citing works
Nail, H. M., Chiu, C., Leung, C., Ahmed, M. M. M., & Wang, H. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00964-w · Cited by 198 · see citing works
Hohlfeld, R., Dornmair, K., Meinl, E., & Wekerle, H. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00334-8 · Cited by 197 · see citing works
Brummelman, J., Haftmann, C., Núñez, N. G., Alvisi, G., Mazza, E. M. C., Becher, B., & Lugli, E. (2019) · Nature Protocols · doi:10.1038/s41596-019-0166-2 · Cited by 196 · see citing works
How many TCR clonotypes does a body maintain?
Lythe, G., Callard, R. E., Hoare, R. L., & Molina-París, C. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.10.016 · Cited by 175 · see citing works
Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits
Aguirre‐Gamboa, R., Joosten, I., Urbano, P. C. M., Molen, R. G. V. D., van Rijssen, E., van Cranenbroek, B., Oosting, M., Smeekens, S. P., Jaeger, M., Zorro, M. M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.053 · Cited by 194 · see citing works
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 189 · see citing works
Immune checkpoint inhibitors and elderly people: A review
Daste, A., Domblides, C., Gross‐Goupil, M., Chakiba, C., Quivy, A., Cochin, V., de Monès, E., Larmonier, N., Soubeyran, P., & Ravaud, A. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.05.044 · Cited by 189 · see citing works
Hohlfeld, R., Dornmair, K., Meinl, E., & Wekerle, H. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00313-0 · Cited by 179 · see citing works
Curing HIV: Seeking to Target and Clear Persistent Infection
Margolis, D. M., Archin, N. M., Cohen, M. S., Eron, J. J., Ferrari, G., García, J. V., Gay, C. L., Goonetilleke, N. P., Joseph, S., Swanstrom, R. I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.005 · Cited by 171 · see citing works
Characterizing immune repertoires by high throughput sequencing: strategies and applications
Calis, J. J. A., & Rosenberg, B. R. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.09.004 · Cited by 178 · see citing works
Biasco, L., Scala, S., Basso Ricci, L., Dionisio, F., Baricordi, C., Calabria, A., Giannelli, S., Cieri, N., Barzaghi, F., Pajno, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010314 · Cited by 175 · see citing works
The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases
DeMaio, A., Mehrotra, S., Sambamurti, K., & Husain, S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02605-9 · Cited by 184 · see citing works
Long-term maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites
Thome, J. J. C., Grinshpun, B., Kumar, B. V., Kubota, M., Ohmura, Y., Lerner, H., Sempowski, G. D., Shen, Y., & Farber, D. L. (2016) · Science Immunology · doi:10.1126/sciimmunol.aah6506 · Cited by 162 · see citing works
The known unknowns of T cell immunity to COVID-19
Karlsson, A. C., Humbert, M., & Buggert, M. (2020) · Science Immunology · doi:10.1126/sciimmunol.abe8063 · Cited by 165 · see citing works
Choucair, K., Morand, S. M., Stanbery, L., Edelman, G. M., Dworkin, L. D., & Nemunaitis, J. J. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0174-y · Cited by 165 · see citing works
Mitochondrial activity in T cells
Desdín-Micó, G., Soto‐Heredero, G., & Mittelbrunn, M. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.10.006 · Cited by 162 · see citing works
Murray, A. J., Kwon, K. J., Färber, D. L., & Siliciano, R. F. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600343 · Cited by 154 · see citing works
Understanding immunosenescence and its impact on vaccination of older adults
Allen, J. C., Toapanta, F. R., Chen, W. H., & Tennant, S. M. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.11.002 · Cited by 157 · see citing works
TET2 guards against unchecked BATF3-induced CAR T cell expansion
Jain, N., Zhao, Z., Feucht, J., Koche, R. P., Iyer, A., Dobrin, A., Mansilla‐Soto, J., Yang, J. L., Zhan, Y. A., Lopez, M. A., et al. (2023) · Nature · doi:10.1038/s41586-022-05692-z · Cited by 154 · see citing works
Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
Banchereau, R., Chitre, A. S., Scherl, A., Wu, T. D., Patil, N. S., de Almeida, P. E., Kadel, E. E., Madireddi, S., Au‐Yeung, A., Takahashi, C., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002231 · Cited by 148 · see citing works
Pillet, S., Aubin, É., Trépanier, S., Bussière, D., Dargis, M., Poulin, J., Yassine‐Diab, B., Ward, B. J., & Landry, N. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.03.008 · Cited by 144 · see citing works
Emerging concepts in tissue-resident T cells: lessons from humans
Thome, J. J. C., & Färber, D. L. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.05.003 · Cited by 144 · see citing works
Stock, S., Schmitt, M. W., & Sellner, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246223 · Cited by 143 · see citing works
Brandt, E. B., Myers, J. M. B., Acciani, T. H., Ryan, P., Sivaprasad, U., Ruff, B. P., LeMasters, G. K., Bernstein, D. I., Lockey, J. E., Cras, T. D. L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.043 · Cited by 138 · see citing works
Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases
Jiang, Q., Yang, G., Xiao, F., Xie, J., Wang, S., Lu, L., & Cui, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.688066 · Cited by 138 · see citing works
Leukocyte-mediated Delivery of Nanotherapeutics in Inflammatory and Tumor Sites
Dong, X., Chu, D., & Wang, Z. (2017) · Theranostics · doi:10.7150/thno.18069 · Cited by 136 · see citing works
Exploiting Mucosal Immunity for Antiviral Vaccines
Iwasaki, A. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112315 · Cited by 132 · see citing works
McKinstry, K. K., Strutt, T. M., Bautista, B., Zhang, W., Kuang, Y., Cooper, A. M., & Swain, S. L. (2014) · Nature Communications · doi:10.1038/ncomms6377 · Cited by 131 · see citing works
Rosenbloom, D. I. S., Elliott, O., Hill, A. L., Henrich, T. J., Siliciano, J. D., & Siliciano, R. F. (2015) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofv123 · Cited by 126 · see citing works
Luque‐Campos, N., Contreras-López, R. A., Paredes-Martínez, M. J., Torres, M. J., Bahraoui, S., Wei, M., Espinoza, F., Djouad, F., Elizondo-Vega, R. J., & Luz‐Crawford, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00798 · Cited by 128 · see citing works
Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection
Stolley, J. M., Johnston, T. S., Soerens, A. G., Beura, L. K., Rosato, P. C., Joag, V., Wijeyesinghe, S., Langlois, R. A., Osum, K. C., Mitchell, J. S., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192197 · Cited by 126 · see citing works
TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
Tu, A. A., Gierahn, T. M., Monian, B., Morgan, D. M., Mehta, N. K., Ruiter, B., Shreffler, W. G., Shalek, A. K., & Love, J. C. (2019) · Nature Immunology · doi:10.1038/s41590-019-0544-5 · Cited by 128 · see citing works
PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation
Petrelli, A., Mijnheer, G., van Konijnenburg, D. P. H., van der Wal, M. M., Giovannone, B., Mocholi, E., Vazirpanah, N., Broen, J. C., Hijnen, D., Oldenburg, B., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96107 · Cited by 126 · see citing works
Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variants
Kingstad-Bakke, B. A., Lee, W., Chandrasekar, S., Gasper, D. J., Salas-Quinchucua, C., Cleven, T., Sullivan, J. A., Talaat, A. M., Osorio, J. E., & Suresh, M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118312119 · Cited by 119 · see citing works
Wong, M. T., Chen, J., Narayanan, S., Lin, W., Anicete, R., Tan, H. K. K., de Lafaille, M. A. C., Poidinger, M., & Newell, E. W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.022 · Cited by 123 · see citing works
Phung, C. D., Pham, T. T., Nguyen, H. T., Nguyen, T. T., Ou, W., Jeong, J., Choi, H., Ku, S., Yong, C. S., & Kim, J. O. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.08.008 · Cited by 124 · see citing works
Kaartinen, T., Luostarinen, A., Maliniemi, P., Keto, J., Arvas, M., Belt, H., Koponen, J., Loskog, A., Mustjoki, S. M., Porkka, K., et al. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.03.067 · Cited by 124 · see citing works
Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells
Zhang, H., Liu, J., Yuan, W., Zhang, Q., Luo, X. L., Li, Y., Peng, Y., Feng, J., Liu, X., Chen, J., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01503-x · Cited by 123 · see citing works
Tong, P. L., Roediger, B., Kolesnikoff, N., Biro, M., Tay, S. S., Jain, R., Shaw, L. E., Grimbaldeston, M. A., & Weninger, W. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.289 · Cited by 115 · see citing works
Elevation and persistence of CD8 T‐cells in HIV infection: the Achilles heel in the ART era
Cao, W., Mehraj, V., Kaufmann, D., Li, T., & Routy, J. (2016) · Journal of the International AIDS Society · doi:10.7448/ias.19.1.20697 · Cited by 115 · see citing works
Defining features of protective CD4 T cell responses to Mycobacterium tuberculosis
Sakai, S., Mayer-Barber, K. D., & Barber, D. L. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.06.003 · Cited by 118 · see citing works
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Wu, Y., Biswas, D., Usaite, I., Angelova, M., Boeing, S., Karasaki, T., Veeriah, S., Czyzewska-Khan, J., Morton, C., Joseph, M., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00376-z · Cited by 118 · see citing works
Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population
Milner, J. J., Nguyen, H., Omilusik, K. D., Reina‐Campos, M., Tsai, M. S., Toma, C., Delpoux, A., Boland, B. S., Hedrick, S. Μ., Chang, J. T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008571117 · Cited by 117 · see citing works
Ding, D., Zhong, H., Liang, R., Lan, T., Zhu, X., Huang, S., Wang, Y., Shao, J., Shuai, X., & Wei, B. (2021) · Advanced Science · doi:10.1002/advs.202100712 · Cited by 117 · see citing works
- Authors
- Farber, D. L., Yudanin, N. A., & Restifo, N. P.
- Affiliations
- Columbia University Irving Medical Center (US)
- National Institutes of Health (US)
- Venue
- Nature Reviews Immunology
- Published
- 2013-12-13
- Volume
- 14
- Issue
- 1
- Pages
- 24-35
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4032067
- OpenAlex
- W2033505817
- Cited by
- 897
- References
- 153
- Citations by year
- 2026: 50 · 2025: 53 · 2024: 81 · 2023: 64 · 2022: 78 · 2021: 91 · 2020: 85 · 2019: 86 · 2018: 78 · 2017: 83 · 2016: 69 · 2015: 54 · 2014: 25
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (U01AI100119, AI106697, U19AI083022, P01AI106697, R01AI100119, AI100119, AI 083022)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- memory T cells, immunological memory, human T cells, T cell subsets, T cell heterogeneity, mucosal immunity, lymphoid tissue, spatial compartmentalization, T cell homeostasis, T cell generation
- MeSH terms
- Animals, Antigens, Cross Reactions, Homeostasis, Humans, Immunologic Memory, Lymphoid Tissue, Vaccines, T-Lymphocyte Subsets, Models, Immunological, Immunity, Mucosal, Mice, Adaptive Immunity, Microbiota
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