The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Tracking the clonal origin of lethal prostate cancer
Open accessAbstract
Recent controversies surrounding prostate cancer overtreatment emphasize the critical need to delineate the molecular features associated with progression to lethal metastatic disease. Here, we have used whole-genome sequencing and molecular pathological analyses to characterize the lethal cell clone in a patient who died of prostate cancer. We tracked the evolution of the lethal cell clone from the primary cancer to metastases through samples collected during disease progression and at the time of death. Surprisingly, these analyses revealed that the lethal clone arose from a small, relatively low-grade cancer focus in the primary tumor, and not from the bulk, higher-grade primary cancer or from a lymph node metastasis resected at prostatectomy. Despite being limited to one case, these findings highlight the potential importance of developing and implementing molecular prognostic and predictive markers, such as alterations of tumor suppressor proteins PTEN or p53, to augment current pathological evaluation and delineate clonal heterogeneity. Furthermore, this case illustrates the potential need in precision medicine to longitudinally sample metastatic lesions to capture the evolving constellation of alterations during progression. Similar comprehensive studies of additional prostate cancer cases are warranted to understand the extent to which these issues may challenge prostate cancer clinical management.
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The mutational landscape of lethal castration-resistant prostate cancer
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Distant metastasis occurs late during the genetic evolution of pancreatic cancer
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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
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Self-citation
Cited by
Palma, D. A., Olson, R., Harrow, S., Gaede, S., Louie, A. V., Haasbeek, C., Mulroy, L., Lock, M., Rodrigues, G. B., Yaremko, B. P., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00818 · Cited by 1,300
Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
McGranahan, N., & Swanton, C. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.001 · Cited by 1,077
Brastianos, P. K., Carter, S. L., Santagata, S., Cahill, D. P., Taylor-Weiner, A., Jones, R. T., Van Allen, E. M., Lawrence, M. S., Horowitz, P. M., Cibulskis, K., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0369 · Cited by 1,082
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Metastasis as an evolutionary process
Turajlic, S., & Swanton, C. (2016) · Science · doi:10.1126/science.aaf2784 · Cited by 661
Metadata
- Authors
- Haffner, M. C., Mosbruger, T., Esopi, D. M., Fedor, H., Heaphy, C. M., Walker, D. A., Adejola, N., Gürel, M., Hicks, J., Meeker, A. K., Halushka, M. K., Simons, J. W., Isaacs, W. B., De Marzo, A. M., Nelson, W. G., & Yegnasubramanian, S.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-10-25
- Volume
- 123
- Issue
- 11
- Pages
- 4918-4922
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2020276643
- Cited by
- 497
- References
- 8
- FWCI
- 47.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Haffner, M. C., Mosbruger, T., Esopi, D. M., Fedor, H., Heaphy, C. M., Walker, D. A., Adejola, N., Gürel, M., Hicks, J., Meeker, A. K., Halushka, M. K., Simons, J. W., Isaacs, W. B., De Marzo, A. M., Nelson, W. G., & Yegnasubramanian, S. (2013). Tracking the clonal origin of lethal prostate cancer. Journal of Clinical Investigation. https://doi.org/10.1172/jci70354
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