The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Memory regulatory T cells reside in human skin
Open accessAbstract
Regulatory T cells (Tregs), which are characterized by expression of the transcription factor Foxp3, are a dynamic and heterogeneous population of cells that control immune responses and prevent autoimmunity. We recently identified a subset of Tregs in murine skin with properties typical of memory cells and defined this population as memory Tregs (mTregs). Due to the importance of these cells in regulating tissue inflammation in mice, we analyzed this cell population in humans and found that almost all Tregs in normal skin had an activated memory phenotype. Compared with mTregs in peripheral blood, cutaneous mTregs had unique cell surface marker expression and cytokine production. In normal human skin, mTregs preferentially localized to hair follicles and were more abundant in skin with high hair density. Sequence comparison of TCRs from conventional memory T helper cells and mTregs isolated from skin revealed little homology between the two cell populations, suggesting that they recognize different antigens. Under steady-state conditions, mTregs were nonmigratory and relatively unresponsive; however, in inflamed skin from psoriasis patients, mTregs expanded, were highly proliferative, and produced low levels of IL-17. Taken together, these results identify a subset of Tregs that stably resides in human skin and suggest that these cells are qualitatively defective in inflammatory skin disease.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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“Given that CCR7 mediates the migration of memory T cells to secondary lymphoid organs (17), we analyzed the expression of this chemokine receptor on cutaneous mTregs and mTconvs.”
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
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PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
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“In addition, Foxp3-expressing Tconvs express lower levels of CD25 and do not repress CD127 expression or IL-2 production (23).”
Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120822 · Cited by 649
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Cited by
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980
“There are a large number of Tregs presenting in the skin [23].”
BackgroundHuman T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Homeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261
Regulatory T cells in autoimmune disease
Dominguez-Villar, M., & Hafler, D. A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0120-4 · Cited by 713
CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin
Cheuk, S., Schlums, H., Gallais Sérézal, I., Martini, E., Chiang, S. C., Marquardt, N., Gibbs, A., Detlofsson, E., Introini, A., Forkel, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.009 · Cited by 678
Metadata
- Authors
- Sanchez Rodriguez, R., Pauli, M. L., Neuhaus, I. M., Yu, S. S., Arron, S. T., Harris, H. W., Yang, S. H.-Y., Anthony, B. A., Sverdrup, F. M., Krow-Lucal, E., MacKenzie, T. C., Johnson, D. S., Meyer, E. H., Löhr, A., Hsu, A., Koo, J., Liao, W., Gupta, R., Debbaneh, M. G., Butler, D., Huynh, M., Levin, E. C., Leon, A., Hoffman, W. Y., McGrath, M. H., Alvarado, M. D., Ludwig, C. H., Truong, H.-A., Maurano, M. M., Gratz, I. K., Abbas, A. K., & Rosenblum, M. D.
- Venue
- Journal of Clinical Investigation
- Published
- 2014-02-10
- Volume
- 124
- Issue
- 3
- Pages
- 1027-1036
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1971079822
- Cited by
- 354
- References
- 6
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Sanchez Rodriguez, R., Pauli, M. L., Neuhaus, I. M., Yu, S. S., Arron, S. T., Harris, H. W., Yang, S. H.-Y., Anthony, B. A., Sverdrup, F. M., Krow-Lucal, E., MacKenzie, T. C., Johnson, D. S., Meyer, E. H., Löhr, A., Hsu, A., Koo, J., Liao, W., Gupta, R., Debbaneh, M. G., . . . Rosenblum, M. D. (2014). Memory regulatory T cells reside in human skin. Journal of Clinical Investigation. https://doi.org/10.1172/jci72932
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